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Entpd8 Gene Detail
Summary
  • Symbol
    Entpd8
  • Name
    ectonucleoside triphosphate diphosphohydrolase 8
  • Feature Type
    protein coding gene
  • IDs
    MGI:1919340
    NCBI Gene: 72090
  • Alliance
    genome feature page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:24970316-24975728 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 16.97 cM, cytoband A3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    201 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1919340
 protein coding gene Chr2:24969308-24975731 (+)
129S1/SvImJ ENSMUSG00200051915
 protein coding gene Chr2:21953327-21960320 (+)
A/J ENSMUSG00195043348
 protein coding gene Chr2:22043789-22050790 (+)
AKR/J ENSMUSG00220053102
 protein coding gene Chr2:22161628-22168629 (+)
BALB/cJ ENSMUSG00180051866
 protein coding gene Chr2:22054968-22061969 (+)
C3H/HeJ ENSMUSG00175047496
 protein coding gene Chr2:22019160-22026157 (+)
C57BL/6NJ ENSMUSG00215047337
 protein coding gene Chr2:22077851-22084848 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0023247
 protein coding gene Chr2:20977942-20983584 (+)
CAST/EiJ ENSTCUG00005052427
 protein coding gene Chr2:21798619-21805635 (+)
CBA/J ENSMUSG00210016124
 protein coding gene Chr2:22058140-22065141 (+)
DBA/2J ENSMUSG00185052628
 protein coding gene Chr2:21958062-21965063 (+)
FVB/NJ ENSMUSG00205045274
 protein coding gene Chr2:21812056-21819053 (+)
JF1/MsJ ENSUMUG00000055311
 protein coding gene Chr2:21873311-21880322 (+)
LP/J ENSMUSG00230038072
 protein coding gene Chr2:23889337-23896334 (+)
NOD/ShiLtJ ENSMUSG00190031557
 protein coding gene Chr2:22049634-22056631 (+)
NZO/HlLtJ ENSMUSG00225010444
 protein coding gene Chr2:31639993-31646994 (+)
PWK/PhJ ENSLUMG00010040814
 protein coding gene Chr2:21968039-21975023 (+)
SPRET/EiJ ENSMSPG00010030867
 protein coding gene Chr2:22657603-22663639 (+)
WSB/EiJ ENSIUOG00005051163
 protein coding gene Chr2:21915005-21922006 (+)



Homology
more
  • Human Ortholog
    ENTPD8, ectonucleoside triphosphate diphosphohydrolase 8
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ENTPD8, ectonucleoside triphosphate diphosphohydrolase 8
  • Synonyms
    E-NTPDase, GLSR2492, NTPDase-8, UNQ2492
  • Links
    NCBI Gene ID: 377841
    UniProt: Q5MY95

  • Chr Location
    9q34.3; chr9:137434362-137441881 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    1 phenotype from multigenic genotypes
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele display elevated colonic ATP levels and increased sensitivity to induced colitis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    49
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    718
  • Tissues
    105
  • cDNA Data
    6
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000036813 Ensembl Gene Model | MGI Sequence Detail 5413 C57BL/6J ±  kb
    transcript ENSMUST00000044078 Ensembl | MGI Sequence Detail 2299 Not Applicable  
    polypeptide ENSMUSP00000040628 Ensembl | MGI Sequence Detail 497 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 7
      cDNA 6
      Primer pair 1

      Microarray probesets 2
    References
    more
    • Summaries
      All 40
      Developmental Gene Expression 2
      Gene Ontology 11
      Phenotypes 9
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:381475 Kelestemur T, et al., NTPDase8 Protects Against Liver Ischemia-Reperfusion Injury in Mice. FASEB J. 2025 Jul 15;39(13):e70775
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory