Poglut2 MGI Mouse Gene Detail - MGI:1919300 - protein O-glucosyltransferase 2

Symbol

Poglut2
Name

protein O-glucosyltransferase 2
Synonyms

1810049A15Rik, 5730416C13Rik, EP58, Kdel1, Kdelc1

Feature Type

protein coding gene
IDs

MGI:1919300
NCBI Gene: 72050
Alliance

genome feature page
Transcription Start Sites

2 TSS

Sequence Map

Chr1:44145706-44157968 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 23.54 cM, cytoband C1
Mapping Data

3 experiments

SNPs within 2kb

416 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1919300	protein coding gene	Chr1:44143060-44158844 (-)
129S1/SvImJ	ENSMUSG00200001819	protein coding gene	Chr1:41774642-41786898 (-)
A/J	ENSMUSG00195001825	protein coding gene	Chr1:41488781-41501035 (-)
AKR/J	ENSMUSG00220003171	protein coding gene	Chr1:41479580-41491833 (-)
BALB/cJ	ENSMUSG00180002982	protein coding gene	Chr1:41490828-41503091 (-)
C3H/HeJ	ENSMUSG00175000088	protein coding gene	Chr1:41496430-41508684 (-)
C57BL/6NJ	ENSMUSG00215002971	protein coding gene	Chr1:41465931-41478193 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014100	protein coding gene	Chr1:38645572-38657820 (-)
CAST/EiJ	ENSTCUG00005000796	protein coding gene	Chr1:41563992-41576189 (-)
CBA/J	ENSMUSG00210028488	protein coding gene	Chr1:41248009-41260263 (-)
DBA/2J	ENSMUSG00185029907	protein coding gene	Chr1:42349191-42361445 (-)
FVB/NJ	ENSMUSG00205003119	protein coding gene	Chr1:41427456-41439709 (-)
JF1/MsJ	ENSUMUG00000001823	protein coding gene	Chr1:41557261-41569470 (-)
LP/J	ENSMUSG00230000959	protein coding gene	Chr1:42376373-42388635 (-)
NOD/ShiLtJ	ENSMUSG00190002238	protein coding gene	Chr1:41453156-41465409 (-)
NZO/HlLtJ	ENSMUSG00225000514	protein coding gene	Chr1:45611514-45623776 (-)
PWK/PhJ	ENSLUMG00010002252	protein coding gene	Chr1:41064398-41076606 (-)
SPRET/EiJ	ENSMSPG00010012806	protein coding gene	Chr1:42663912-42676053 (-)
WSB/EiJ	ENSIUOG00005003528	protein coding gene	Chr1:41427073-41439314 (-)

Human Ortholog

POGLUT2, protein O-glucosyltransferase 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

POGLUT2, protein O-glucosyltransferase 2
Synonyms

EP58, ERp58, KDEL1, KDELC1
Links

HGNC:19350

NCBI Gene ID: 79070

UniProt: Q6UW63
Chr Location

13q33.1; chr13:102784281-102799040 (-) GRCh38

MGI Vertebrate Homology

Poglut2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: POGLUT2
Gene Tree

Poglut2

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Phenotype Summary

2 phenotypes from 2 alleles in 2 genetic backgrounds
14 phenotypes from multigenic genotypes
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

11
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

1
Targeted

7
Genomic Mutations

1 involving Poglut2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

24 strains or lines available

Homozygous null mice are viable, fertile, and present at expected ratios.

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All GO Annotations

24
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

618
Tissues

17
cDNA Data

63
Literature Summary

4

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

ZFIN poglut2

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All Sequences

55
RefSeq

3
UniProt

2
CCDS

CCDS14929.1

Ensembl

ENSMUSG00000026047 (Evidence)
NCBI Gene

72050

			Length	Strain/Species	Flank
genomic	ENSMUSG00000026047	Ensembl Gene Model \| MGI Sequence Detail	12263	C57BL/6J	± kb
transcript	ENSMUST00000065767	Ensembl \| MGI Sequence Detail	2359	Not Applicable
polypeptide	ENSMUSP00000064500	Ensembl \| MGI Sequence Detail	502	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000031874 protein O-glucosyltransferase 2

(term hierarchy)
EC

2.4.1.-, 2.4.2.-
InterPro Domains

IPR001298 Filamin/ABP280 repeat

IPR017868 Filamin/ABP280 repeat-like

IPR006598 Glycosyl transferase CAP10 domain

IPR014756 Immunoglobulin E-set

IPR013783 Immunoglobulin-like fold

IPR051091 Protein O-Glucosyltransferase/Glycosyltransferase 90
GlyGen

Q9JHP7 3 sites, 4 N-linked glycans (3 sites)

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All nucleic 67

cDNA 64

Primer pair 3

Microarray probesets 4

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MGI:1917775, MGI:6285830

Summaries

All 46

Developmental Gene Expression 4

Gene Ontology 7

Phenotypes 11
Earliest

J:67334 Kimata Y, et al., Identification of a novel mammalian endoplasmic reticulum-resident KDEL protein using an EST database motif search. Gene. 2000 Dec 31;261(2):321-7
Latest

J:350484 Neupane S, et al., Poglut2/3 double knockout in mice results in neonatal lethality with reduced levels of fibrillin in lung tissues. J Biol Chem. 2024 Jun 4;300(7):107445

TSS for Poglut2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr11521	Chr1:44157917-44157976 (-)	21 bp
Tssr11520	Chr1:44157871-44157882 (-)	91 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/15/2026 MGI 6.29