Sars2 MGI Mouse Gene Detail - MGI:1919234 - seryl-aminoacyl-tRNA synthetase 2

Symbol

Sars2
Name

seryl-aminoacyl-tRNA synthetase 2
Synonyms

2410015F05Rik, D7Ertd353e

Feature Type

protein coding gene
IDs

MGI:1919234
NCBI Gene: 71984
Alliance

gene page
Transcription Start Sites

1 TSS

Sequence Map

Chr7:28441417-28453296 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 16.91 cM
Mapping Data

3 experiments

SNPs within 2kb

126 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1919234	protein coding gene	Chr7:28441393-28453304 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0031957	protein coding gene	Chr7:27573832-27588964 (+)
A/J	MGP_AJ_G0031935	protein coding gene	Chr7:26888562-26900745 (+)
AKR/J	MGP_AKRJ_G0031867	protein coding gene	Chr7:27580315-27593512 (+)
BALB/cJ	MGP_BALBcJ_G0031942	protein coding gene	Chr7:27047940-27060602 (+)
C3H/HeJ	MGP_C3HHeJ_G0031661	protein coding gene	Chr7:27956838-27969202 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0032406	protein coding gene	Chr7:28474552-28491402 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0029458	protein coding gene	Chr7:27949490-27961298 (+)
CAST/EiJ	MGP_CASTEiJ_G0030996	protein coding gene	Chr7:21276309-21288854 (+)
CBA/J	MGP_CBAJ_G0031627	protein coding gene	Chr7:29746533-29761032 (+)
DBA/2J	MGP_DBA2J_G0031779	protein coding gene	Chr7:26642122-26653599 (+)
FVB/NJ	MGP_FVBNJ_G0031736	protein coding gene	Chr7:26717609-26731932 (+)
LP/J	MGP_LPJ_G0031859	protein coding gene	Chr7:27901615-27913740 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0031772	protein coding gene	Chr7:29211880-29232272 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0032436	protein coding gene	Chr7:27059778-27072053 (+)
PWK/PhJ	MGP_PWKPhJ_G0030721	protein coding gene	Chr7:21665720-21679158 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0030554	protein coding gene	Chr7:18078571-18091061 (+)
WSB/EiJ	MGP_WSBEiJ_G0031105	protein coding gene	Chr7:27428929-27444046 (+)

Human Ortholog

SARS2, seryl-tRNA synthetase 2, mitochondrial

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SARS2, seryl-tRNA synthetase 2, mitochondrial
Synonyms

mtSerRS, SARS, SARSM, SerRS, SerRSmt, SERS, SYS
Links

HGNC:17697

NCBI Gene ID: 54938

neXtProt AC: NX_Q9NP81

UniProt: Q9NP81
Chr Location

19q13.2; chr19:38915266-38930763 (-) GRCh38

MGI Vertebrate Homology

Sars2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: SARS2
Gene Tree

Sars2

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Phenotype Summary

3 phenotype references

All Mutations and Alleles

5
Gene trapped

3
Targeted

2
Incidental Mutations

APF
Find Mice (IMSR)

20 strains or lines available

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All GO Annotations

11
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

800
Tissues

94
cDNA Data

49
Literature Summary

1

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase sars2

ZFIN sars2

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All Sequences

47
RefSeq

7
UniProt

2
CCDS

CCDS21053.1

Ensembl

ENSMUSG00000070699 (Evidence)
NCBI Gene

71984

			Length	Strain/Species	Flank
genomic	ENSMUSG00000070699	Ensembl Gene Model \| MGI Sequence Detail	11880	C57BL/6J	± kb
transcript	ENSMUST00000094632	Ensembl \| MGI Sequence Detail	1868	Not Applicable
polypeptide	ENSMUSP00000092216	Ensembl \| MGI Sequence Detail	518	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000014460 serine--tRNA ligase, mitochondrial

(term hierarchy)
EC

6.1.1.11
InterPro Domains

IPR006195 Aminoacyl-tRNA synthetase, class II

IPR002314 Aminoacyl-tRNA synthetase, class II (G/ P/ S/T)

IPR010978 Class I and II aminoacyl-tRNA synthetase, tRNA-binding arm

IPR045864 Class II Aminoacyl-tRNA synthetase/Biotinyl protein ligase (BPL) and lipoyl protein ligase (LPL)

IPR033729 Serine-tRNA ligase catalytic core domain

IPR002317 Serine-tRNA ligase, type1

IPR015866 Serine-tRNA synthetase, type1, N-terminal

IPR042103 Serine-tRNA synthetase, type1, N-terminal domain superfamily

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All nucleic 50

cDNA 49

Primer pair 1

Microarray probesets 3

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MGI:1196425

Summaries

All 31

Developmental Gene Expression 1

Gene Ontology 5

Phenotypes 3
Earliest

J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
Latest

J:237827 Gineste C, et al., In vivo and in vitro investigations of heterozygous nebulin knock-out mice disclose a mild skeletal muscle phenotype. Neuromuscul Disord. 2013 Apr;23(4):357-69

TSS for Sars2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr65505	Chr7:28441400-28441438 (+)	2 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/23/2024 MGI 6.23