Castor1 MGI Mouse Gene Detail - MGI:1919212 - cytosolic arginine sensor for mTORC1 subunit 1

Symbol

Castor1
Name

cytosolic arginine sensor for mTORC1 subunit 1
Synonyms

2410008K03Rik, Gatsl3

Feature Type

protein coding gene
IDs

MGI:1919212
NCBI Gene: 71962
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr11:4168225-4172409 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 2.94 cM, cytoband A1
Mapping Data

3 experiments

SNPs within 2kb

12 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1919212	protein coding gene	Chr11:4167401-4172409 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0017979	protein coding gene	Chr11:1150807-1154991 (+)
A/J	MGP_AJ_G0017952	protein coding gene	Chr11:1162819-1167003 (+)
AKR/J	MGP_AKRJ_G0017916	protein coding gene	Chr11:1216652-1220836 (+)
BALB/cJ	MGP_BALBcJ_G0017920	protein coding gene	Chr11:1132186-1136370 (+)
C3H/HeJ	MGP_C3HHeJ_G0017733	protein coding gene	Chr11:1114548-1118732 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0018373	protein coding gene	Chr11:1230789-1234973 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016031	protein coding gene	Chr11:1042015-1046311 (+)
CAST/EiJ	MGP_CASTEiJ_G0017295	protein coding gene	Chr11:1076262-1080419 (+)
CBA/J	MGP_CBAJ_G0017708	protein coding gene	Chr11:1479892-1484076 (+)
DBA/2J	MGP_DBA2J_G0017819	protein coding gene	Chr11:1066750-1070934 (+)
FVB/NJ	MGP_FVBNJ_G0017810	protein coding gene	Chr11:1099000-1103184 (+)
LP/J	MGP_LPJ_G0017889	protein coding gene	Chr11:1256499-1260683 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017836	protein coding gene	Chr11:1145306-1149490 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0018412	protein coding gene	Chr11:1224532-1228716 (+)
PWK/PhJ	MGP_PWKPhJ_G0017076	protein coding gene	Chr11:1068826-1073010 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0016872	protein coding gene	Chr11:1187062-1191345 (+)
WSB/EiJ	MGP_WSBEiJ_G0017349	protein coding gene	Chr11:1088914-1093098 (+)

Human Ortholog

CASTOR1, cytosolic arginine sensor for mTORC1 subunit 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CASTOR1, cytosolic arginine sensor for mTORC1 subunit 1
Synonyms

GATSL3
Links

HGNC:34423

NCBI Gene ID: 652968

neXtProt AC: NX_Q8WTX7

UniProt: Q8WTX7
Chr Location

22q12.2; chr22:30285117-30289622 (-) GRCh38

MGI Vertebrate Homology

Castor1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: CASTOR1
Gene Tree

Castor1

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
8 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Endonuclease-mediated

2
Gene trapped

2
Targeted

4
Incidental Mutations

APF , CvDC
Find Mice (IMSR)

23 strains or lines available

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All GO Annotations

24
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

753
Tissues

19
cDNA Data

22
Literature Summary

2

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase castor1

ZFIN castor1

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All Sequences

37
RefSeq

6
UniProt

1
CCDS

CCDS24381.1

Ensembl

ENSMUSG00000020424 (Evidence)
NCBI Gene

71962

			Length	Strain/Species	Flank
genomic	ENSMUSG00000020424	Ensembl Gene Model \| MGI Sequence Detail	4185	C57BL/6J	± kb
transcript	ENSMUST00000020699	Ensembl \| MGI Sequence Detail	1574	Not Applicable
polypeptide	ENSMUSP00000020699	Ensembl \| MGI Sequence Detail	331	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000007866 cytosolic arginine sensor for mTORC1 subunit 1

(term hierarchy)
InterPro Domains

IPR045865 ACT-like domain

IPR040778 CASTOR1, N-terminal

IPR027795 CASTOR, ACT domain

IPR026249 CASTOR family

IPR049479 Cytosolic arginine sensor for mTORC1 subunit 1/2, ACT-like

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All nucleic 22

cDNA 22

Microarray probesets 3

Summaries

All 34

Developmental Gene Expression 2

Gene Ontology 4

Phenotypes 8
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:329904 Iskarpatyoti JA, et al., Mast cell regranulation requires a metabolic switch involving mTORC1 and a glucose-6-phosphate transporter. Cell Rep. 2022 Sep 27;40(13):111346

TSS for Castor1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr100103	Chr11:4168220-4168249 (+)	10 bp
Tssr100104	Chr11:4168255-4168279 (+)	42 bp
Tssr100105	Chr11:4170702-4170742 (+)	2,497 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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