Apmap MGI Mouse Gene Detail - MGI:1919131 - adipocyte plasma membrane associated protein

Symbol

Apmap
Name

adipocyte plasma membrane associated protein
Synonyms

2310001A20Rik

Feature Type

protein coding gene
IDs

MGI:1919131
NCBI Gene: 71881
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr2:150425000-150450487 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 74.68 cM
Mapping Data

2 experiments

SNPs within 2kb

199 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1919131	protein coding gene	Chr2:150425000-150450487 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0026627	protein coding gene	Chr2:155031419-155056896 (-)
A/J	MGP_AJ_G0026594	protein coding gene	Chr2:148788181-148813867 (-)
AKR/J	MGP_AKRJ_G0026565	protein coding gene	Chr2:153108337-153135742 (-)
BALB/cJ	MGP_BALBcJ_G0026604	protein coding gene	Chr2:149208145-149236505 (-)
C3H/HeJ	MGP_C3HHeJ_G0026347	protein coding gene	Chr2:153549772-153575148 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0027052	protein coding gene	Chr2:159564356-159590075 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0024424	protein coding gene	Chr2:142657038-142683358 (-)
CAST/EiJ	MGP_CASTEiJ_G0025807	protein coding gene	Chr2:153787837-153813005 (-)
CBA/J	MGP_CBAJ_G0026326	protein coding gene	Chr2:165412370-165441962 (-)
DBA/2J	MGP_DBA2J_G0026460	protein coding gene	Chr2:148028166-148053587 (-)
FVB/NJ	MGP_FVBNJ_G0026425	protein coding gene	Chr2:146487734-146514421 (-)
LP/J	MGP_LPJ_G0026564	protein coding gene	Chr2:155171354-155197471 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0026447	protein coding gene	Chr2:169520075-169547091 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0027107	protein coding gene	Chr2:153044110-153073729 (-)
PWK/PhJ	MGP_PWKPhJ_G0025542	protein coding gene	Chr2:147662095-147687946 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0025344	protein coding gene	Chr2:151966022-151991259 (-)
WSB/EiJ	MGP_WSBEiJ_G0025880	protein coding gene	Chr2:154008048-154036975 (-)

Human Ortholog

APMAP, adipocyte plasma membrane associated protein

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

APMAP, adipocyte plasma membrane associated protein
Synonyms

BSCv, C20orf3
Links

HGNC:13238

NCBI Gene ID: 57136

neXtProt AC: NX_Q9HDC9

UniProt: Q9HDC9
Chr Location

20p11.21; chr20:24962925-24992751 (-) GRCh38

MGI Vertebrate Homology

Apmap stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: APMAP
Gene Tree

Apmap

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Phenotype Summary

37 phenotypes from 3 alleles in 3 genetic backgrounds
2 phenotypes from multigenic genotypes
10 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Chemically induced (other)

1
Endonuclease-mediated

2
Radiation induced

1
Targeted

5
Genomic Mutations

2 involving Apmap
Incidental Mutations

APF
Find Mice (IMSR)

19 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygotes for a null allele show spatial memory deficits. Under a high-fat diet, homozygous deletion of exon 1 results in increased insulin sensitivity, improved glucose tolerance, increased respiratory exchange ratio, decreased inflammatory marker gene expression, and reduced adipocyte size.

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All GO Annotations

9
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

714
Tissues

1
cDNA Data

85
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA APMAP

Xenbase apmap, apmapl

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All Sequences

50
RefSeq

10
UniProt

1
CCDS

CCDS16858.1

Ensembl

ENSMUSG00000033096 (Evidence)
NCBI Gene

71881

			Length	Strain/Species	Flank
genomic	71881	NCBI Gene Model \| MGI Sequence Detail	25488	C57BL/6J	± kb
transcript	NM_001356492	RefSeq \| MGI Sequence Detail	2427	C57BL/6
polypeptide	Q9D7N9	UniProt \| EBI \| MGI Sequence Detail	415	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000004139 adipocyte plasma membrane-associated protein

(term hierarchy)
InterPro Domains

IPR011042 Six-bladed beta-propeller, TolB-like

IPR018119 Strictosidine synthase, conserved region

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All nucleic 85

cDNA 85

Microarray probesets 4

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MGI:2138883

Summaries

All 38

Developmental Gene Expression 2

Gene Ontology 6

Phenotypes 10
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;

TSS for Apmap:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr26709	Chr2:150450422-150450481 (-)	35 bp
Tssr26708	Chr2:150450410-150450421 (-)	71 bp
Tssr26707	Chr2:150442335-150442383 (-)	8,128 bp
Tssr26706	Chr2:150442317-150442333 (-)	8,162 bp
Tssr26705	Chr2:150442294-150442303 (-)	8,188 bp
Tssr26704	Chr2:150442274-150442287 (-)	8,206 bp
Tssr26703	Chr2:150442261-150442272 (-)	8,220 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23