Cenpu MGI Mouse Gene Detail - MGI:1919126

Symbol

Cenpu
Name

centromere protein U
Synonyms

1700029A22Rik, Mlf1ip

Feature Type

protein coding gene
IDs

MGI:1919126
NCBI Gene: 71876
Alliance

genome feature page
Transcription Start Sites

1 TSS

Sequence Map

Chr8:47005063-47033042 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 8, 26.38 cM, cytoband B2
Mapping Data

2 experiments

SNPs within 2kb

1091 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1919126	protein coding gene	Chr8:47005054-47033603 (+)
129S1/SvImJ	ENSMUSG00200005753	protein coding gene	Chr8:42110472-42138451 (+)
A/J	ENSMUSG00195004028	protein coding gene	Chr8:42609499-42637485 (+)
AKR/J	ENSMUSG00220003740	protein coding gene	Chr8:42426255-42454240 (+)
BALB/cJ	ENSMUSG00180002905	protein coding gene	Chr8:42150513-42178494 (+)
C3H/HeJ	ENSMUSG00175005029	protein coding gene	Chr8:42278838-42306822 (+)
C57BL/6NJ	ENSMUSG00215006680	protein coding gene	Chr8:42081588-42109575 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0031033	protein coding gene	Chr8:40146622-40170950 (+)
CAST/EiJ	ENSTCUG00005018747	protein coding gene	Chr8:42116848-42145091 (+)
CBA/J	ENSMUSG00210018733	protein coding gene	Chr8:42174986-42202967 (+)
DBA/2J	ENSMUSG00185005557	protein coding gene	Chr8:48021323-48049301 (+)
FVB/NJ	ENSMUSG00205002681	protein coding gene	Chr8:41304612-41332596 (+)
JF1/MsJ	ENSUMUG00000007751	protein coding gene	Chr8:49682885-49711134 (+)
LP/J	ENSMUSG00230014687	protein coding gene	Chr8:51713884-51741864 (+)
NOD/ShiLtJ	ENSMUSG00190005607	protein coding gene	Chr8:42194407-42222384 (+)
NZO/HlLtJ	ENSMUSG00225011281	protein coding gene	Chr8:55300749-55328727 (+)
PWK/PhJ	ENSLUMG00010008998	protein coding gene	Chr8:41953592-41981625 (+)
SPRET/EiJ	ENSMSPG00010005539	protein coding gene	Chr8:42827348-42853763 (+)
WSB/EiJ	ENSIUOG00005002488	protein coding gene	Chr8:43027324-43056112 (+)

Human Ortholog

CENPU, centromere protein U

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CENPU, centromere protein U
Synonyms

CENP50, CENPU50, KLIP1, MLF1IP, PBIP1
Links

HGNC:21348

NCBI Gene ID: 79682

UniProt: Q71F23
Chr Location

4q35.1; chr4:184694085-184734130 (-) GRCh38

MGI Vertebrate Homology

Cenpu stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: CENPU
Gene Tree

Cenpu

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Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
1 images
10 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

17
Chemically induced (other)

1
Gene trapped

9
Targeted

7
Genomic Mutations

1 involving Cenpu
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

17 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit embryonic lethality between E7.5 and E9.5, small embryo size and thickened visceral endoderm.

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All GO Annotations

15
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

745
Tissues

89
cDNA Data

12
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase cenpu

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All Sequences

63
RefSeq

8
UniProt

5
CCDS

CCDS22292.1

Ensembl

ENSMUSG00000031629 (Evidence)
NCBI Gene

71876

			Length	Strain/Species	Flank
genomic	ENSMUSG00000031629	Ensembl Gene Model \| MGI Sequence Detail	27980	C57BL/6J	± kb
transcript	ENSMUST00000034045	Ensembl \| MGI Sequence Detail	2931	Not Applicable
polypeptide	ENSMUSP00000034045	Ensembl \| MGI Sequence Detail	410	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000010440 centromere protein U

(term hierarchy)
InterPro Domains

IPR025214 Centromere protein U

IPR027417 P-loop containing nucleoside triphosphate hydrolase

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All nucleic 15

cDNA 13

Primer pair 2

Antibodies 1

Microarray probesets 5

Summaries

All 40

Developmental Gene Expression 3

Gene Ontology 7

Phenotypes 10
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:338156 Tian T, et al., Structural insights into human CCAN complex assembled onto DNA. Cell Discov. 2022 Sep 9;8(1):90

TSS for Cenpu:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr77271	Chr8:47005059-47005114 (+)	24 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/08/2026 MGI 6.24