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Cfap45 Gene Detail
Summary
  • Symbol
    Cfap45
  • Name
    cilia and flagella associated protein 45
  • Synonyms
    1700028D05Rik, Ccdc19, Nesg1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1919120
    NCBI Gene: 71870
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:172348697-172373437 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 1, 79.91 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    726 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1919120
protein coding gene Chr1:172348368-172373437 (+)
129S1/SvImJ MGP_129S1SvImJ_G0016791
protein coding gene Chr1:178393441-178419943 (+)
A/J MGP_AJ_G0016770
protein coding gene Chr1:171104900-171131551 (+)
AKR/J MGP_AKRJ_G0016736
protein coding gene Chr1:176262203-176288796 (+)
BALB/cJ MGP_BALBcJ_G0016731
protein coding gene Chr1:171637339-171662529 (+)
C3H/HeJ MGP_C3HHeJ_G0016555
protein coding gene Chr1:176836991-176862996 (+)
C57BL/6NJ MGP_C57BL6NJ_G0017193
protein coding gene Chr1:184318459-184343421 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014899
protein coding gene Chr1:162791861-162817211 (+)
CAST/EiJ MGP_CASTEiJ_G0016135
protein coding gene Chr1:176206240-176232492 (+)
CBA/J MGP_CBAJ_G0016529
protein coding gene Chr1:190867209-190892041 (+)
DBA/2J MGP_DBA2J_G0016636
protein coding gene Chr1:170024918-170049744 (+)
FVB/NJ MGP_FVBNJ_G0016633
protein coding gene Chr1:168283080-168308469 (+)
LP/J MGP_LPJ_G0016707
protein coding gene Chr1:179475440-179500604 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0016660
protein coding gene Chr1:198097539-198122676 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0017229
protein coding gene Chr1:176136297-176163817 (+)
PWK/PhJ MGP_PWKPhJ_G0015921
protein coding gene Chr1:169407461-169432797 (+)
SPRET/EiJ MGP_SPRETEiJ_G0015703
protein coding gene Chr1:175089248-175121528 (+)
WSB/EiJ MGP_WSBEiJ_G0016197
protein coding gene Chr1:176285951-176310866 (+)



Homology
more
  • Human Ortholog
    CFAP45, cilia and flagella associated protein 45
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CFAP45, cilia and flagella associated protein 45
  • Synonyms
    CCDC19, HTX11, NESG1
  • Links
    NCBI Gene ID: 25790
    neXtProt AC: NX_Q9UL16
    UniProt: Q9UL16

  • Chr Location
    1q23.2; chr1:159872364-159900165 (-)  GRCh38

Human Diseases
more
  • Diseases
    1 with human CFAP45 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    18 phenotypes from 1 allele in 1 genetic background
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit left-right asymmetry abnormalities including situs inversus totalis and asthenospermia, due to dyskinetic beating of embryonic nodal cilia and sperm flagella, respectively.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 71870 NCBI Gene Model | MGI Sequence Detail 24741 C57BL/6J ±  kb
    transcript NM_027972 RefSeq | MGI Sequence Detail 1822 ZRU/MplStud  
    polypeptide Q9D9U9 UniProt | EBI | MGI Sequence Detail 551 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 14
      Genomic 1
      cDNA 12
      Primer pair 1

      Microarray probesets 2
    References
    more
    • Summaries
      All 33
      Developmental Gene Expression 3
      Gene Ontology 6
      Phenotypes 8
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    07/05/2024
    MGI 6.24
    The Jackson Laboratory