Erich3 MGI Mouse Gene Detail - MGI:1919095

Symbol

Erich3
Name

glutamate rich 3
Synonyms

4922501L14Rik, 5031409G23Rik

Feature Type

protein coding gene
IDs

MGI:1919095
NCBI Gene: 209601
Alliance

genome feature page
Transcription Start Sites

11 TSS

Sequence Map

Chr3:154416770-154454649 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 3, 79.28 cM
Mapping Data

4 experiments

SNPs within 2kb

1144 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1919095	protein coding gene	Chr3:154369496-154473427 (+)
129S1/SvImJ	ENSMUSG00200002445	protein coding gene	Chr3:151340334-151444253 (+)
A/J	ENSMUSG00195003343	protein coding gene	Chr3:151456433-151560297 (+)
AKR/J	ENSMUSG00220000352	protein coding gene	Chr3:149869454-149973387 (+)
BALB/cJ	ENSMUSG00180025099	protein coding gene	Chr3:151308305-151412154 (+)
C3H/HeJ	ENSMUSG00175018790	protein coding gene	Chr3:150924903-151028756 (+)
C57BL/6NJ	ENSMUSG00215010376	protein coding gene	Chr3:151568988-151672940 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0025757	protein coding gene	Chr3:147641422-147746447 (+)
CAST/EiJ	ENSTCUG00005001156	protein coding gene	Chr3:151988267-152092067 (+)
CBA/J	ENSMUSG00210004259	protein coding gene	Chr3:151565991-151669935 (+)
DBA/2J	ENSMUSG00185000064	protein coding gene	Chr3:152194450-152298323 (+)
FVB/NJ	ENSMUSG00205008519	protein coding gene	Chr3:150496205-150604688 (+)
JF1/MsJ	ENSUMUG00000024000	protein coding gene	Chr3:150947386-151053553 (+)
LP/J	ENSMUSG00230009385	protein coding gene	Chr3:154089338-154193266 (+)
NOD/ShiLtJ	ENSMUSG00190004080	protein coding gene	Chr3:152548109-152651963 (+)
NZO/HlLtJ	ENSMUSG00225005137	protein coding gene	Chr3:156589047-156692894 (+)
PWK/PhJ	ENSLUMG00010001697	protein coding gene	Chr3:150891756-150997819 (+)
SPRET/EiJ	ENSMSPG00010000281	protein coding gene	Chr3:152223031-152332532 (+)
WSB/EiJ	ENSIUOG00005015349	protein coding gene	Chr3:151669338-151773118 (+)

Human Ortholog

ERICH3, glutamate rich 3

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ERICH3, glutamate rich 3
Synonyms

C1orf173
Links

HGNC:25346

NCBI Gene ID: 127254

UniProt: Q5RHP9
Chr Location

1p31.1; chr1:74568117-74674343 (-) GRCh38

MGI Vertebrate Homology

Erich3 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: ERICH3
Gene Tree

Erich3

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Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
8 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Endonuclease-mediated

4
Targeted

2
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

51 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

11
GO References

3

Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

597
cDNA Data

11
Literature Summary

1

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase erich3

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All Sequences

46
RefSeq

3
UniProt

4
CCDS

CCDS51099.1

Ensembl

ENSMUSG00000078161 (Evidence)
NCBI Gene

209601

			Length	Strain/Species	Flank
genomic	209601	NCBI Gene Model \| MGI Sequence Detail	37880	C57BL/6J	± kb
transcript	NM_175176	RefSeq \| MGI Sequence Detail	2009	C57BL/6
polypeptide	F6QRE9	UniProt \| EBI \| MGI Sequence Detail	1637	Not Applicable

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UniProt

4 Sequences
InterPro Domains

IPR048257 Domain of unknown function DUF4590

IPR027962 Glutamate-rich protein 3
GlyGen

F6QRE9 2 sites

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All nucleic 13

Genomic 2

cDNA 11

Microarray probesets 6

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MGI:2139761, MGI:2684418, MGI:2684979

Summaries

All 38

Developmental Gene Expression 1

Gene Ontology 3

Phenotypes 8
Earliest

J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Erich3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr32458	Chr3:154416722-154416733 (+)	-42 bp
Tssr32459	Chr3:154416734-154416744 (+)	-31 bp
Tssr32460	Chr3:154416745-154416758 (+)	-18 bp
Tssr32461	Chr3:154416762-154416770 (+)	-4 bp
Tssr32462	Chr3:154416776-154416781 (+)	9 bp
Tssr32463	Chr3:154416788-154416799 (+)	24 bp
Tssr32464	Chr3:154417027-154417039 (+)	263 bp
Tssr1102	Chr3:154417047-154417053 (+)	280 bp
Tssr1103	Chr3:154417060-154417065 (+)	293 bp
Tssr32465	Chr3:154423714-154423728 (+)	6,951 bp
Tssr32466	Chr3:154423729-154423747 (+)	6,968 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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