Tekt4 MGI Mouse Gene Detail - MGI:1919090

Symbol

Tekt4
Name

tektin 4
Synonyms

1700010L19Rik

Feature Type

protein coding gene
IDs

MGI:1919090
NCBI Gene: 71840
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr17:25673515-25695576 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 17, 12.60 cM, cytoband A3.3
Mapping Data

2 experiments

SNPs within 2kb

175 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1919090	protein coding gene	Chr17:25673511-25695576 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0023356	protein coding gene	Chr17:24545396-24550398 (+)
A/J	MGP_AJ_G0023315	protein coding gene	Chr17:23843820-23848822 (+)
AKR/J	MGP_AKRJ_G0023281	protein coding gene	Chr17:23945036-23950040 (+)
BALB/cJ	MGP_BALBcJ_G0023320	protein coding gene	Chr17:24058950-24063952 (+)
C3H/HeJ	MGP_C3HHeJ_G0023080	protein coding gene	Chr17:24323469-24328471 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0023762	protein coding gene	Chr17:25604103-25609107 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0021238	protein coding gene	Chr17:21304446-21309440 (+)
CAST/EiJ	MGP_CASTEiJ_G0022582	protein coding gene	Chr17:24193225-24198231 (+)
CBA/J	MGP_CBAJ_G0023055	protein coding gene	Chr17:26491019-26496021 (+)
DBA/2J	MGP_DBA2J_G0023185	protein coding gene	Chr17:23441333-23446335 (+)
FVB/NJ	MGP_FVBNJ_G0023155	protein coding gene	Chr17:23159733-23164735 (+)
LP/J	MGP_LPJ_G0023262	protein coding gene	Chr17:24841357-24846359 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0023174	protein coding gene	Chr17:26128255-26133257 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0023802	protein coding gene	Chr17:24239634-24244636 (+)
PWK/PhJ	MGP_PWKPhJ_G0022331	protein coding gene	Chr17:22195969-22200971 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0022149	protein coding gene	Chr17:22323261-22328205 (+)
WSB/EiJ	MGP_WSBEiJ_G0022645	protein coding gene	Chr17:24306365-24311367 (+)

Human Ortholog

TEKT4, tektin 4

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TEKT4, tektin 4
Links

HGNC:31012

NCBI Gene ID: 150483

neXtProt AC: NX_Q8WW24

UniProt: Q8WW24
Chr Location

2q11.1; chr2:94871430-94876823 (+) GRCh38

MGI Vertebrate Homology

Tekt4 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: TEKT4
Gene Tree

Tekt4

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Phenotype Summary

8 phenotypes from 1 allele in 2 genetic backgrounds
2 phenotypes from multigenic genotypes
8 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Gene trapped

1
Radiation induced

2
Targeted

3
Genomic Mutations

2 involving Tekt4
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

17 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele exhibit decreased male fertility due to abnormal flagellum function.

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All GO Annotations

13
GO References

8

Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

733
Tissues

3
cDNA Data

12
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase tekt4

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All Sequences

58
RefSeq

8
UniProt

3
CCDS

CCDS28519.1

Ensembl

ENSMUSG00000024175 (Evidence)
NCBI Gene

71840

			Length	Strain/Species	Flank
genomic	ENSMUSG00000024175	Ensembl Gene Model \| MGI Sequence Detail	22062	C57BL/6J	± kb
transcript	ENSMUST00000025002	Ensembl \| MGI Sequence Detail	1562	Not Applicable
polypeptide	ENSMUSP00000025002	Ensembl \| MGI Sequence Detail	447	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000016229 tektin-4

(term hierarchy)
PDB

8I7O, 8I7R, 8IYJ, 8TO0
InterPro Domains

IPR048256 Tektin-like

IPR000435 Tektins

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All nucleic 12

cDNA 12

Microarray probesets 3

Summaries

All 34

Developmental Gene Expression 1

Gene Ontology 8

Phenotypes 8
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:338030 Zhou L, et al., Structures of sperm flagellar doublet microtubules expand the genetic spectrum of male infertility. Cell. 2023 Jun 22;186(13):2897-2910.e19

TSS for Tekt4:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr143159	Chr17:25672693-25672716 (+)	-810 bp
Tssr143160	Chr17:25673501-25673527 (+)	-1 bp
Tssr143161	Chr17:25690538-25690611 (+)	17,060 bp
Tssr143162	Chr17:25690647-25690662 (+)	17,140 bp
Tssr143163	Chr17:25690677-25690691 (+)	17,169 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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