Rnf180 MGI Mouse Gene Detail - MGI:1919066

Symbol

Rnf180
Name

ring finger protein 180
Synonyms

3110001E11Rik, Rines

Feature Type

protein coding gene
IDs

MGI:1919066
NCBI Gene: 71816
Alliance

gene page
Transcription Start Sites

19 TSS

Sequence Map

Chr13:105267075-105431406 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 13, 56.92 cM, cytoband D1
Mapping Data

2 experiments

SNPs within 2kb

730 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1919066	protein coding gene	Chr13:105266509-105431406 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0020914	protein coding gene	Chr13:107267417-107417646 (-)
A/J	MGP_AJ_G0020865	protein coding gene	Chr13:103082016-103227496 (-)
AKR/J	MGP_AKRJ_G0020840	protein coding gene	Chr13:106215078-106357468 (-)
BALB/cJ	MGP_BALBcJ_G0020865	protein coding gene	Chr13:103790365-103942289 (-)
C3H/HeJ	MGP_C3HHeJ_G0020654	protein coding gene	Chr13:105971192-106119986 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0021299	protein coding gene	Chr13:110491339-110645533 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018869	protein coding gene	Chr13:98658796-98799463 (-)
CAST/EiJ	MGP_CASTEiJ_G0020173	protein coding gene	Chr13:105488674-105653006 (-)
CBA/J	MGP_CBAJ_G0020616	protein coding gene	Chr13:114796360-114953694 (-)
DBA/2J	MGP_DBA2J_G0020740	protein coding gene	Chr13:102840358-102986544 (-)
FVB/NJ	MGP_FVBNJ_G0020722	protein coding gene	Chr13:101535408-101680404 (-)
LP/J	MGP_LPJ_G0020814	protein coding gene	Chr13:107294671-107449925 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0020750	protein coding gene	Chr13:115037882-115193618 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0021338	protein coding gene	Chr13:105699154-105856467 (-)
PWK/PhJ	MGP_PWKPhJ_G0019926	protein coding gene	Chr13:101577976-101746747 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0019748	protein coding gene	Chr13:101963167-102079011 (-)
WSB/EiJ	MGP_WSBEiJ_G0020231	protein coding gene	Chr13:106171042-106318602 (-)

Human Ortholog

RNF180, ring finger protein 180

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

RNF180, ring finger protein 180
Synonyms

RINES
Links

HGNC:27752

NCBI Gene ID: 285671

neXtProt AC: NX_Q86T96

UniProt: Q86T96
Chr Location

5q12.3; chr5:64165351-64372869 (+) GRCh38

MGI Vertebrate Homology

Rnf180 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: RNF180
Gene Tree

Rnf180

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Phenotype Summary

14 phenotypes from 2 alleles in 2 genetic backgrounds
7 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

5
Endonuclease-mediated

3
Targeted

2
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

21 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Knock-out mice show impaired stress responses, enhanced anxiety, and affiliative behavior. Norepinephrine and serotonin levels are decreased in the locus ceruleus, prefrontal cortex, and amygdala and MAO-A enzyme activity is enhanced in the locus ceruleus.

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All GO Annotations

21
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

921
Tissues

101
cDNA Data

21
Literature Summary

5

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase rnf180

ZFIN rnf180b

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All Sequences

88
RefSeq

42
UniProt

3
CCDS

CCDS36775.1, CCDS88517.1, CCDS88518.1

Ensembl

ENSMUSG00000021720 (Evidence)
NCBI Gene

71816

			Length	Strain/Species	Flank
genomic	71816	NCBI Gene Model \| MGI Sequence Detail	164332	C57BL/6J	± kb
transcript	NM_027934	RefSeq \| MGI Sequence Detail	3785	C57BL/6
polypeptide	Q3U827	UniProt \| EBI \| MGI Sequence Detail	592	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000014106 E3 ubiquitin-protein ligase RNF180

(term hierarchy)
EC

2.3.2.27
InterPro Domains

IPR033263 E3 ubiquitin-protein ligase RNF180

IPR045790 E3 ubiquitin-protein ligase RNF180, C-terminal domain

IPR018957 Zinc finger, C3HC4 RING-type

IPR013083 Zinc finger, RING/FYVE/PHD-type

IPR001841 Zinc finger, RING-type

IPR017907 Zinc finger, RING-type, conserved site

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All nucleic 21

cDNA 21

Microarray probesets 3

Summaries

All 33

Developmental Gene Expression 5

Gene Ontology 5

Phenotypes 7
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:199865 Kabayama M, et al., Rines E3 Ubiquitin Ligase Regulates MAO-A Levels and Emotional Responses. J Neurosci. 2013 Aug 7;33(32):12940-53

TSS for Rnf180:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr123961	Chr13:105431327-105431337 (-)	74 bp
Tssr123960	Chr13:105431165-105431174 (-)	236 bp
Tssr123959	Chr13:105430934-105430979 (-)	449 bp
Tssr123958	Chr13:105430889-105430927 (-)	498 bp
Tssr123957	Chr13:105430857-105430866 (-)	544 bp
Tssr123956	Chr13:105430811-105430848 (-)	576 bp
Tssr123955	Chr13:105430798-105430810 (-)	602 bp
Tssr123954	Chr13:105429512-105429523 (-)	1,888 bp
Tssr123953	Chr13:105428460-105428482 (-)	2,935 bp
Tssr123952	Chr13:105428422-105428446 (-)	2,972 bp
Tssr123951	Chr13:105386998-105387007 (-)	44,403 bp
Tssr123950	Chr13:105386957-105386987 (-)	44,434 bp
Tssr123949	Chr13:105386946-105386955 (-)	44,455 bp
Tssr123948	Chr13:105386309-105386324 (-)	45,089 bp
Tssr123947	Chr13:105386217-105386258 (-)	45,168 bp
Tssr123946	Chr13:105386194-105386216 (-)	45,201 bp
Tssr123945	Chr13:105379305-105379318 (-)	52,094 bp
Tssr123944	Chr13:105379160-105379174 (-)	52,239 bp
Tssr123943	Chr13:105379142-105379157 (-)	52,256 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23