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Pdgfd Gene Detail
Summary
  • Symbol
    Pdgfd
  • Name
    platelet-derived growth factor, D polypeptide
  • Synonyms
    1110003I09Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1919035
    NCBI Gene: 71785
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:6168584-6378850 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 2.46 cM, cytoband A1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1196 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1919035
 protein coding gene Chr9:6168377-6534284 (+)
129S1/SvImJ MGP_129S1SvImJ_G0034315
 protein coding gene Chr9:3007958-3235809 (+)
A/J MGP_AJ_G0034292
 protein coding gene Chr9:3101258-3324695 (+)
AKR/J MGP_AKRJ_G0034222
 protein coding gene Chr9:2974027-3196620 (+)
BALB/cJ MGP_BALBcJ_G0034286
 protein coding gene Chr9:2834205-3069923 (+)
C3H/HeJ MGP_C3HHeJ_G0033998
 protein coding gene Chr9:3179567-3399495 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034808
 protein coding gene Chr9:3165982-3382309 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031746
 protein coding gene Chr9:2493423-2734003 (+)
CAST/EiJ MGP_CASTEiJ_G0033325
 protein coding gene Chr9:3191678-3408297 (+)
CBA/J MGP_CBAJ_G0033970
 protein coding gene Chr9:3194853-3423784 (+)
DBA/2J MGP_DBA2J_G0034127
 protein coding gene Chr9:3012433-3223655 (+)
FVB/NJ MGP_FVBNJ_G0034072
 protein coding gene Chr9:2840975-3051620 (+)
LP/J MGP_LPJ_G0034214
 protein coding gene Chr9:3039222-3258714 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0034116
 protein coding gene Chr9:3825740-4067625 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034827
 protein coding gene Chr9:2953907-3174787 (+)
PWK/PhJ MGP_PWKPhJ_G0033029
 protein coding gene Chr9:3186826-3416244 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032866
 protein coding gene Chr9:3262140-3491402 (+)
WSB/EiJ MGP_WSBEiJ_G0033441
 protein coding gene Chr9:2983101-3205263 (+)



Homology
more
  • Human Ortholog
    PDGFD, platelet derived growth factor D
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PDGFD, platelet derived growth factor D
  • Synonyms
    IEGF, MSTP036, SCDGFB, SCDGF-B
  • Links
    NCBI Gene ID: 80310
    neXtProt AC: NX_Q9GZP0
    UniProt: Q9GZP0

  • Chr Location
    11q22.3; chr11:103907189-104164379 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human PDGFD associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotypes from 2 alleles in 2 genetic backgrounds
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele show a mild vascular phenotype characterized by abnormal pericyte morphology within cardiac tissue, slightly increased systolic and diastolic blood pressure, and altered serum levels of calcium and chloride ions.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    26
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    741
  • Tissues
    24
  • cDNA Data
    7
  • Literature Summary
    8
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000032006 Ensembl Gene Model | MGI Sequence Detail 210267 C57BL/6J ±  kb
    transcript ENSMUST00000168039 Ensembl | MGI Sequence Detail 1795 Not Applicable  
    polypeptide ENSMUSP00000128388 Ensembl | MGI Sequence Detail 370 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 7
      cDNA 7

      Microarray probesets 4
    References
    more
    • Summaries
      All 56
      Developmental Gene Expression 8
      Gene Ontology 9
      Phenotypes 12
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:336289 Kim HJ, et al., Molecular mechanisms of coronary artery disease risk at the PDGFD locus. Nat Commun. 2023 Feb 15;14(1):847
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory