Isyna1 MGI Mouse Gene Detail - MGI:1919030 - myo-inositol 1-phosphate synthase A1

Symbol

Isyna1
Name

myo-inositol 1-phosphate synthase A1
Synonyms

1300017C10Rik, inositol-3-phosphate synthase 1, myo-inositol 1-phosphate synthase A1

Feature Type

protein coding gene
IDs

MGI:1919030
NCBI Gene: 71780
Alliance

genome feature page
Transcription Start Sites

9 TSS

Sequence Map

Chr8:71047131-71049940 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 8, 34.15 cM
Mapping Data

2 experiments

SNPs within 2kb

91 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1919030	protein coding gene	Chr8:71047023-71049940 (+)
129S1/SvImJ	ENSMUSG00200025504	protein coding gene	Chr8:65844098-65847016 (+)
A/J	ENSMUSG00195013496	protein coding gene	Chr8:66177856-66180773 (+)
AKR/J	ENSMUSG00220024142	protein coding gene	Chr8:66089552-66092452 (+)
BALB/cJ	ENSMUSG00180024145	protein coding gene	Chr8:65820514-65823432 (+)
C3H/HeJ	ENSMUSG00175021093	protein coding gene	Chr8:66100441-66103359 (+)
C57BL/6NJ	ENSMUSG00215034236	protein coding gene	Chr8:65780332-65783249 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0031153	protein coding gene	Chr8:62810365-62813134 (+)
CAST/EiJ	ENSTCUG00005039283	protein coding gene	Chr8:65575555-65578454 (+)
CBA/J	ENSMUSG00210029405	protein coding gene	Chr8:65866009-65868927 (+)
DBA/2J	ENSMUSG00185012792	protein coding gene	Chr8:72025611-72028529 (+)
FVB/NJ	ENSMUSG00205034368	protein coding gene	Chr8:65370237-65373155 (+)
JF1/MsJ	ENSUMUG00000034050	protein coding gene	Chr8:74306157-74309074 (+)
LP/J	ENSMUSG00230029193	protein coding gene	Chr8:75637166-75640084 (+)
NOD/ShiLtJ	ENSMUSG00190024053	protein coding gene	Chr8:65787460-65790377 (+)
NZO/HlLtJ	ENSMUSG00225047537	protein coding gene	Chr8:79046321-79049239 (+)
PWK/PhJ	ENSLUMG00010030623	protein coding gene	Chr8:65763143-65766060 (+)
SPRET/EiJ	ENSMSPG00010030794	protein coding gene	Chr8:67450265-67453181 (+)
WSB/EiJ	ENSIUOG00005023748	protein coding gene	Chr8:66657116-66660016 (+)

Human Ortholog

ISYNA1, inositol-3-phosphate synthase 1

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ISYNA1, inositol-3-phosphate synthase 1
Synonyms

INO1, INOS, IPS, IPS 1, IPS-1
Links

HGNC:29821

NCBI Gene ID: 51477

UniProt: Q9NPH2
Chr Location

19p13.11; chr19:18434388-18438178 (-) GRCh38

MGI Vertebrate Homology

Isyna1 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: ISYNA1
Protein SuperFamily

Myoinos-ppht_syn
Gene Tree

Isyna1

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Phenotype Summary

14 phenotypes from 1 allele in 1 genetic background
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

5
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

1
Targeted

1
Genomic Mutations

1 involving Isyna1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

16 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

21
GO References

11

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

617
Tissues

10
cDNA Data

185
Literature Summary

4

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase isyna1

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All Sequences

54
RefSeq

2
UniProt

4
CCDS

CCDS22373.1

Ensembl

ENSMUSG00000019139 (Evidence)
NCBI Gene

71780

			Length	Strain/Species	Flank
genomic	71780	NCBI Gene Model \| MGI Sequence Detail	2810	C57BL/6J	± kb
transcript	NM_023627	RefSeq \| MGI Sequence Detail	1850	Not Specified
polypeptide	Q9JHU9	UniProt \| EBI \| MGI Sequence Detail	557	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000009122 inositol-3-phosphate synthase 1

(term hierarchy)
EC

5.5.1.4
InterPro Domains

IPR002587 Myo-inositol-1-phosphate synthase

IPR013021 Myo-inositol-1-phosphate synthase, GAPDH-like

IPR036291 NAD(P)-binding domain superfamily
GlyGen

Q9JHU9 2 sites, 1 N-linked glycan (1 site)

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All nucleic 190

cDNA 186

Primer pair 4

Microarray probesets 4

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MGI:2142685

Summaries

All 48

Developmental Gene Expression 4

Gene Ontology 11

Phenotypes 12
Earliest

J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
Latest

J:363264 Leung KY, et al., Association of embryonic inositol status with susceptibility to neural tube defects, metabolite profile, and maternal inositol intake. FASEB J. 2024 Jun 15;38(11):e23738

TSS for Isyna1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr77768	Chr8:71046826-71046860 (+)	-288 bp
Tssr77769	Chr8:71047011-71047022 (+)	-114 bp
Tssr77770	Chr8:71047025-71047046 (+)	-95 bp
Tssr77771	Chr8:71047051-71047062 (+)	-74 bp
Tssr77772	Chr8:71047075-71047090 (+)	-48 bp
Tssr77773	Chr8:71047116-71047162 (+)	8 bp
Tssr77774	Chr8:71047263-71047299 (+)	150 bp
Tssr77775	Chr8:71047694-71047723 (+)	578 bp
Tssr77776	Chr8:71049475-71049501 (+)	2,357 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/15/2026 MGI 6.29