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Marchf8 Gene Detail
Summary
  • Symbol
    Marchf8
  • Name
    membrane associated ring-CH-type finger 8
  • Synonyms
    1300017E09Rik, March8, Mir
  • Feature Type
    protein coding gene
  • IDs
    MGI:1919029
    NCBI Gene: 71779
  • Alliance
    genome feature page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:116314985-116386501 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 53.78 cM, cytoband F1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1876 from dbSNP Build 142
  • Strain Annotations
    27
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1919029
 protein coding gene Chr6:116312546-116386501 (+)
129S1/SvImJ ENSMUSGG00200054494
 protein coding gene Chr6:113565977-113566147 (+)
129S1/SvImJ ENSMUSG00200049142
 protein coding gene Chr6:113575456-113598812 (+)
A/J ENSMUSG00195043305
 protein coding gene Chr6:112970583-112993897 (+)
A/J ENSMUSGG00195054974
 protein coding gene Chr6:112961052-112961222 (+)
AKR/J ENSMUSG00220029555
 protein coding gene Chr6:111870580-111890878 (+)
AKR/J ENSMUSGG00220054564
 protein coding gene Chr6:111861031-111861201 (+)
BALB/cJ ENSMUSGG00180055540
 protein coding gene Chr6:113327459-113327629 (+)
BALB/cJ ENSMUSG00180048886
 protein coding gene Chr6:113336992-113360308 (+)
C3H/HeJ ENSMUSG00175028906
 protein coding gene Chr6:64090277-64110581 (-)
C3H/HeJ ENSMUSGG00175054812
 protein coding gene Chr6:64119959-64120129 (-)
C57BL/6NJ ENSMUSG00215044498
 protein coding gene Chr6:113323259-113346575 (+)
C57BL/6NJ ENSMUSGG00215055705
 protein coding gene Chr6:113313728-113313898 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028769
 protein coding gene Chr6:111441219-111510292 (+)
CAST/EiJ no annotation
CBA/J ENSMUSG00210034593
 protein coding gene Chr6:113126962-113147266 (+)
CBA/J ENSMUSGG00210054590
 protein coding gene Chr6:113117413-113117583 (+)
DBA/2J ENSMUSG00185047923
 protein coding gene Chr6:113774012-113797352 (+)
DBA/2J ENSMUSGG00185057432
 protein coding gene Chr6:113764535-113764705 (+)
FVB/NJ ENSMUSG00205022152
 protein coding gene Chr6:112237051-112260408 (+)
FVB/NJ ENSMUSGG00205054589
 protein coding gene Chr6:112227504-112227674 (+)
JF1/MsJ no annotation
LP/J ENSMUSG00230047910
 protein coding gene Chr6:114978254-115001601 (+)
LP/J ENSMUSGG00230055379
 protein coding gene Chr6:114968777-114968947 (+)
NOD/ShiLtJ ENSMUSG00190036425
 protein coding gene Chr6:112728159-112751508 (+)
NOD/ShiLtJ ENSMUSGG00190054620
 protein coding gene Chr6:112718682-112718852 (+)
NZO/HlLtJ ENSMUSGG00225055581
 protein coding gene Chr6:116824502-116824672 (+)
NZO/HlLtJ ENSMUSG00225046804
 protein coding gene Chr6:116833982-116857330 (+)
PWK/PhJ no annotation
SPRET/EiJ ENSMSPG00010044910
 protein coding gene Chr6:114523179-114555955 (+)
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    MARCHF8, membrane associated ring-CH-type finger 8
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MARCHF8, membrane associated ring-CH-type finger 8
  • Synonyms
    c-MIR, CMIR, MARCH8, MARCH-VIII, MIR, RNF178
  • Links
    NCBI Gene ID: 220972
    UniProt: Q5T0T0

  • Chr Location
    10q11.21-q11.22; chr10:45454585-45594931 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 2 alleles in 2 genetic backgrounds
    1 phenotype from multigenic genotypes
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit a normal CD4+ T cell compartment in the thymus.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    46
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    597
  • cDNA Data
    148
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000025702 Ensembl Gene Model | MGI Sequence Detail 71517 C57BL/6J ±  kb
    transcript ENSMUST00000123405 Ensembl | MGI Sequence Detail 2102 Not Applicable  
    polypeptide ENSMUSP00000144936 Ensembl | MGI Sequence Detail 568 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 148
      cDNA 148

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:6368856
    References
    more
    • Summaries
      All 52
      Developmental Gene Expression 1
      Gene Ontology 9
      Phenotypes 15
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:368322 Jiang H, et al., VANGL2 alleviates inflammatory bowel disease by recruiting the ubiquitin ligase MARCH8 to limit NLRP3 inflammasome activation through OPTN-mediated selective autophagy. PLoS Biol. 2025 Feb;23(2):e3002961
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory