Klhl5 MGI Mouse Gene Detail - MGI:1919028

Symbol

Klhl5
Name

kelch-like 5
Synonyms

1300013C10Rik

Feature Type

protein coding gene
IDs

MGI:1919028
NCBI Gene: 71778
Alliance

genome feature page
Transcription Start Sites

11 TSS

Sequence Map

Chr5:65264894-65325490 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 5, 33.58 cM
Mapping Data

1 experiment

SNPs within 2kb

1721 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1919028	protein coding gene	Chr5:65264882-65325531 (+)
129S1/SvImJ	ENSMUSG00200034460	protein coding gene	Chr5:60881657-60942343 (+)
A/J	ENSMUSG00195000208	protein coding gene	Chr5:60251939-60312660 (+)
AKR/J	ENSMUSG00220007022	protein coding gene	Chr5:60393662-60454346 (+)
BALB/cJ	ENSMUSG00180005808	protein coding gene	Chr5:60037789-60098482 (+)
C3H/HeJ	ENSMUSG00175025397	protein coding gene	Chr5:62072025-62132869 (+)
C57BL/6NJ	ENSMUSG00215005141	protein coding gene	Chr5:60810536-60871221 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0027243	protein coding gene	Chr5:58416664-58453738 (+)
CAST/EiJ	ENSTCUG00005000413	protein coding gene	Chr5:59963830-60024415 (+)
CBA/J	ENSMUSG00210022833	protein coding gene	Chr5:60984993-61045824 (+)
DBA/2J	ENSMUSG00185005235	protein coding gene	Chr5:62842507-62903341 (+)
FVB/NJ	ENSMUSG00205010697	protein coding gene	Chr5:59794398-59855071 (+)
JF1/MsJ	ENSUMUG00000016082	protein coding gene	Chr5:67295811-67356858 (+)
LP/J	ENSMUSG00230005656	protein coding gene	Chr5:67494410-67555097 (+)
NOD/ShiLtJ	ENSMUSG00190000285	protein coding gene	Chr5:59977055-60037742 (+)
NZO/HlLtJ	ENSMUSG00225009735	protein coding gene	Chr5:72620458-72681134 (+)
PWK/PhJ	ENSLUMG00010004045	protein coding gene	Chr5:59921294-59981898 (+)
SPRET/EiJ	ENSMSPG00010031811	protein coding gene	Chr5:61742352-61803836 (+)
WSB/EiJ	ENSIUOG00005017485	protein coding gene	Chr5:62933406-62994265 (+)

Human Ortholog

KLHL5, kelch like family member 5

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

KLHL5, kelch like family member 5
Links

HGNC:6356

NCBI Gene ID: 51088

UniProt: Q96PQ7
Chr Location

4p14; chr4:39044721-39143101 (+) GRCh38

MGI Vertebrate Homology

Klhl5 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: KLHL5
Protein SuperFamily

Kelch-like_protein_gigaxonin
Gene Tree

Klhl5

Diseases

1 with human KLHL5 associations

				Human Disease	Mouse Models
				cocaine dependence IDs cocaine dependence DOID:9975 ICD10CM:F14.2 ICD9CM:304.2 ICD9CM:304.20 MESH:D019970 NCI:C34492 UMLS_CUI:C0600427

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

9 phenotypes from 1 allele in 1 genetic background
25 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Chemically induced (other)

2
Endonuclease-mediated

2
Gene trapped

1
Radiation induced

1
Spontaneous

1
Targeted

3
Genomic Mutations

4 involving Klhl5
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

41 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

2
GO References

2

Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.

Biological Process

No experimental evidence to support Biological Process annotation, following literature review. See J:73796.

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

805
Tissues

79
cDNA Data

71
Literature Summary

5

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase klhl5

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All Sequences

77
RefSeq

12
UniProt

8
CCDS

CCDS19305.2, CCDS84883.1

Ensembl

ENSMUSG00000054920 (Evidence)
NCBI Gene

71778

			Length	Strain/Species	Flank
genomic	71778	NCBI Gene Model \| MGI Sequence Detail	60597	C57BL/6J	± kb
transcript	NM_175174	RefSeq \| MGI Sequence Detail	3422	C57BL/6
polypeptide	NP_780383	RefSeq \| MGI Sequence Detail	708	C57BL/6

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UniProt

8 Sequences
InterPro Domains

IPR056737 Attractin/MKLN-like, beta-propeller domain

IPR011705 BTB/Kelch-associated

IPR017096 BTB-kelch protein

IPR000210 BTB/POZ domain

IPR037293 Galactose oxidase, central domain superfamily

IPR030606 Kelch-like protein 5, BTB/POZ domain

IPR006652 Kelch repeat type 1

IPR015915 Kelch-type beta-propeller

IPR011333 SKP1/BTB/POZ domain superfamily

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All nucleic 71

cDNA 71

Microarray probesets 4

Summaries

All 49

Developmental Gene Expression 5

Gene Ontology 2

Phenotypes 25
Earliest

J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Klhl5:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr46442	Chr5:65264894-65264925 (+)	16 bp
Tssr46443	Chr5:65264938-65264956 (+)	53 bp
Tssr46444	Chr5:65264956-65264959 (+)	64 bp
Tssr46445	Chr5:65264961-65264998 (+)	86 bp
Tssr46446	Chr5:65265001-65265008 (+)	111 bp
Tssr46447	Chr5:65272286-65272293 (+)	7,396 bp
Tssr46448	Chr5:65288342-65288353 (+)	23,454 bp
Tssr46449	Chr5:65288452-65288501 (+)	23,583 bp
Tssr46450	Chr5:65288527-65288557 (+)	23,648 bp
Tssr46452	Chr5:65312322-65312333 (+)	47,434 bp
Tssr46453	Chr5:65312438-65312446 (+)	47,548 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/01/2026 MGI 6.24