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Brox Gene Detail
Summary
  • Symbol
    Brox
  • Name
    BRO1 domain and CAAX motif containing
  • Synonyms
    0610010K06Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1918928
    NCBI Gene: 71678
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:183057916-183078813 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 1, Syntenic
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    164 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1918928
protein coding gene Chr1:183057916-183078839 (-)
129S1/SvImJ MGP_129S1SvImJ_G0016901
protein coding gene Chr1:189919260-189943057 (-)
A/J MGP_AJ_G0016880
protein coding gene Chr1:182163803-182184386 (-)
AKR/J MGP_AKRJ_G0016845
protein coding gene Chr1:187578466-187603627 (-)
BALB/cJ MGP_BALBcJ_G0016838
protein coding gene Chr1:182806534-182827944 (-)
C3H/HeJ MGP_C3HHeJ_G0016662
protein coding gene Chr1:188378879-188399965 (-)
C57BL/6NJ MGP_C57BL6NJ_G0017301
protein coding gene Chr1:196018135-196040964 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015008
protein coding gene Chr1:173220511-173241649 (-)
CAST/EiJ MGP_CASTEiJ_G0016245
protein coding gene Chr1:187770181-187791353 (-)
CBA/J MGP_CBAJ_G0016636
protein coding gene Chr1:203321171-203351328 (-)
DBA/2J MGP_DBA2J_G0016742
protein coding gene Chr1:180945569-180966465 (-)
FVB/NJ MGP_FVBNJ_G0016738
protein coding gene Chr1:179078949-179100161 (-)
LP/J MGP_LPJ_G0016817
protein coding gene Chr1:191107889-191130773 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0016770
protein coding gene Chr1:210272408-210292653 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0017338
protein coding gene Chr1:187407049-187427999 (-)
PWK/PhJ MGP_PWKPhJ_G0016032
protein coding gene Chr1:180146405-180167469 (-)
SPRET/EiJ MGP_SPRETEiJ_G0015808
protein coding gene Chr1:186369141-186391527 (-)
WSB/EiJ MGP_WSBEiJ_G0016307
protein coding gene Chr1:187584711-187606655 (-)



Homology
more
  • Human Ortholog
    BROX, BRO1 domain and CAAX motif containing
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    BROX, BRO1 domain and CAAX motif containing
  • Synonyms
    C1orf58
  • Links
    NCBI Gene ID: 148362
    neXtProt AC: NX_Q5VW32
    UniProt: Q5VW32

  • Chr Location
    1q41; chr1:222712553-222735196 (+)  GRCh38

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • cDNA Data
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000046836 Ensembl Gene Model | MGI Sequence Detail 20898 C57BL/6J ±  kb
transcript ENSMUST00000163528 Ensembl | MGI Sequence Detail 3413 Not Applicable  
polypeptide ENSMUSP00000132333 Ensembl | MGI Sequence Detail 411 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 14
    cDNA 14

    Microarray probesets 7
References
more
  • Summaries
    All 30
    Gene Ontology 2
    Phenotypes 6
  • Earliest
    J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-Le-Grand). 1999 Jul;45(5):737-50
  • Latest
    J:166585 Ichioka F, et al., Brox, a novel farnesylated Bro1 domain-containing protein that associates with charged multivesicular body protein 4 (CHMP4). FEBS J. 2008 Feb;275(4):682-92

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
02/13/2024
MGI 6.23
The Jackson Laboratory