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Brox Gene Detail
Summary
  • Symbol
    Brox
  • Name
    BRO1 domain and CAAX motif containing
  • Synonyms
    0610010K06Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1918928
    NCBI Gene: 71678
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:183057916-183078813 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, Syntenic
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    644 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1918928
 protein coding gene Chr1:183057916-183078839 (-)
129S1/SvImJ ENSMUSG00200021791
 protein coding gene Chr1:180825820-180846717 (-)
A/J ENSMUSG00195038825
 protein coding gene Chr1:180411057-180431955 (-)
AKR/J ENSMUSG00220019509
 protein coding gene Chr1:179656550-179677454 (-)
BALB/cJ ENSMUSG00180036109
 protein coding gene Chr1:180477243-180498141 (-)
C3H/HeJ ENSMUSG00175038030
 protein coding gene Chr1:180652856-180673754 (-)
C57BL/6NJ ENSMUSG00215013548
 protein coding gene Chr1:179872461-179893360 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015008
 protein coding gene Chr1:173220511-173241649 (-)
CAST/EiJ no annotation
CBA/J ENSMUSG00210018648
 protein coding gene Chr1:180303428-180324324 (-)
DBA/2J ENSMUSG00185032944
 protein coding gene Chr1:184922854-184943750 (-)
FVB/NJ ENSMUSG00205030546
 protein coding gene Chr1:179347475-179368375 (-)
JF1/MsJ no annotation
LP/J ENSMUSG00230020705
 protein coding gene Chr1:184484990-184505887 (-)
NOD/ShiLtJ ENSMUSG00190023840
 protein coding gene Chr1:180327379-180348276 (-)
NZO/HlLtJ ENSMUSG00225009824
 protein coding gene Chr1:188231683-188252682 (-)
PWK/PhJ ENSLUMG00010016501
 protein coding gene Chr1:179178382-179199278 (-)
SPRET/EiJ ENSMSPG00010027913
 protein coding gene Chr1:182670526-182690039 (-)
WSB/EiJ ENSIUOG00005011280
 protein coding gene Chr1:179518067-179538964 (-)



Homology
more
  • Human Ortholog
    BROX, BRO1 domain and CAAX motif containing
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    BROX, BRO1 domain and CAAX motif containing
  • Synonyms
    C1orf58
  • Links
    NCBI Gene ID: 148362
    UniProt: Q5VW32

  • Chr Location
    1q41; chr1:222711691-222735196 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    8
  • GO References
    4
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    597
  • cDNA Data
    14
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000046836 Ensembl Gene Model | MGI Sequence Detail 20898 C57BL/6J ±  kb
transcript ENSMUST00000057062 Ensembl | MGI Sequence Detail 3430 Not Applicable  
polypeptide ENSMUSP00000061345 Ensembl | MGI Sequence Detail 411 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 14
    cDNA 14

    Microarray probesets 7
References
more
  • Summaries
    All 34
    Gene Ontology 4
    Phenotypes 7
  • Earliest
    J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-Le-Grand). 1999 Jul;45(5):737-50
  • Latest
    J:166585 Ichioka F, et al., Brox, a novel farnesylated Bro1 domain-containing protein that associates with charged multivesicular body protein 4 (CHMP4). FEBS J. 2008 Feb;275(4):682-92
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/01/2026
MGI 6.24 		The Jackson Laboratory