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Rarres2 Gene Detail
Summary
  • Symbol
    Rarres2
  • Name
    retinoic acid receptor responder (tazarotene induced) 2
  • Synonyms
    0610007L05Rik, chemerin
  • Feature Type
    protein coding gene
  • IDs
    MGI:1918910
    NCBI Gene: 71660
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:48546630-48549723 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 23.55 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    166 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1918910
 protein coding gene Chr6:48546630-48549778 (-)
129S1/SvImJ ENSMUSG00200005131
 protein coding gene Chr6:45450614-45455421 (-)
A/J ENSMUSG00195006362
 protein coding gene Chr6:45221191-45226090 (-)
AKR/J ENSMUSG00220003072
 protein coding gene Chr6:44930635-44935524 (-)
BALB/cJ ENSMUSG00180020516
 protein coding gene Chr6:45534044-45538935 (-)
C3H/HeJ ENSMUSG00175015314
 protein coding gene Chr6:45295688-45300577 (-)
C57BL/6NJ ENSMUSG00215006081
 protein coding gene Chr6:45495659-45500470 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028340
 protein coding gene Chr6:42988992-42992610 (-)
CAST/EiJ ENSTCUG00005004294
 protein coding gene Chr6:44812530-44817439 (-)
CBA/J ENSMUSG00210017923
 protein coding gene Chr6:45340528-45345417 (-)
DBA/2J ENSMUSG00185013490
 protein coding gene Chr6:45922221-45927112 (-)
FVB/NJ ENSMUSG00205023064
 protein coding gene Chr6:45586672-45591565 (-)
JF1/MsJ ENSUMUG00000007646
 protein coding gene Chr6:45285200-45289992 (-)
LP/J ENSMUSG00230013937
 protein coding gene Chr6:46947737-46952546 (-)
NOD/ShiLtJ ENSMUSG00190033474
 protein coding gene Chr6:45260190-45265420 (-)
NZO/HlLtJ ENSMUSG00225017554
 protein coding gene Chr6:48984322-48989078 (-)
PWK/PhJ ENSLUMG00010019129
 protein coding gene Chr6:44919743-44924656 (-)
SPRET/EiJ ENSMSPG00010009200
 protein coding gene Chr6:45547295-45550165 (-)
WSB/EiJ ENSIUOG00005026762
 protein coding gene Chr6:45558409-45563314 (-)



Homology
more
  • Human Ortholog
    RARRES2, retinoic acid receptor responder 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RARRES2, retinoic acid receptor responder 2
  • Synonyms
    HP10433, TIG2
  • Links
    NCBI Gene ID: 5919
    UniProt: Q99969

  • Chr Location
    7q36.1; chr7:150338314-150342144 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 1 allele in 1 genetic background
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit impaired glucose tolerance, impaired glucose-stimulated insulin secretion and increased clamp hepatic glucose production.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    55
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    705
  • Tissues
    90
  • cDNA Data
    10
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000009281 Ensembl Gene Model | MGI Sequence Detail 3094 C57BL/6J ±  kb
    transcript ENSMUST00000009425 Ensembl | MGI Sequence Detail 731 Not Applicable  
    polypeptide ENSMUSP00000009425 Ensembl | MGI Sequence Detail 163 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 11
      cDNA 10
      Primer pair 1
      Antibodies 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1889806
    References
    more
    • Summaries
      All 93
      Developmental Gene Expression 7
      Gene Ontology 12
      Phenotypes 16
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:369753 Cai JX, et al., Chemerin sustains the growth of spongiotrophoblast and sinusoidal trophoblast giant cells through fatty acid oxidation. BMC Biol. 2025 Jul 3;23(1):199
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory