Clmp MGI Mouse Gene Detail - MGI:1918816 - CXADR-like membrane protein

Symbol

Clmp
Name

CXADR-like membrane protein
Synonyms

9030425E11Rik

Feature Type

protein coding gene
IDs

MGI:1918816
NCBI Gene: 71566
Alliance

gene page
Transcription Start Sites

21 TSS

Sequence Map

Chr9:40597258-40696615 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 9, 21.42 cM
Mapping Data

3 experiments

SNPs within 2kb

1260 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1918816	protein coding gene	Chr9:40596975-40696849 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0034669	protein coding gene	Chr9:38911750-39020222 (+)
A/J	MGP_AJ_G0034649	protein coding gene	Chr9:37892510-38018311 (+)
AKR/J	MGP_AKRJ_G0034575	protein coding gene	Chr9:38629325-38738222 (+)
BALB/cJ	MGP_BALBcJ_G0034640	protein coding gene	Chr9:37664454-37766357 (+)
C3H/HeJ	MGP_C3HHeJ_G0034351	protein coding gene	Chr9:39145834-39253698 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0035163	protein coding gene	Chr9:40140157-40253720 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0032077	protein coding gene	Chr9:37546072-37646880 (+)
CAST/EiJ	MGP_CASTEiJ_G0033674	protein coding gene	Chr9:38873563-38978691 (+)
CBA/J	MGP_CBAJ_G0034324	protein coding gene	Chr9:41537899-41656323 (+)
DBA/2J	MGP_DBA2J_G0034483	protein coding gene	Chr9:37855842-37958663 (+)
FVB/NJ	MGP_FVBNJ_G0034423	protein coding gene	Chr9:37078479-37181189 (+)
LP/J	MGP_LPJ_G0034564	protein coding gene	Chr9:39196933-39302326 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0034467	protein coding gene	Chr9:43585140-43698471 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0035182	protein coding gene	Chr9:38549812-38656934 (+)
PWK/PhJ	MGP_PWKPhJ_G0033379	protein coding gene	Chr9:37663904-37763224 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0033215	protein coding gene	Chr9:38789603-38891572 (+)
WSB/EiJ	MGP_WSBEiJ_G0033787	protein coding gene	Chr9:38571905-38684605 (+)

Human Ortholog

CLMP, CXADR like membrane protein

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CLMP, CXADR like membrane protein
Synonyms

ACAM, ASAM, CSBM, CSBS
Links

HGNC:24039

NCBI Gene ID: 79827

neXtProt AC: NX_Q9H6B4

UniProt: Q9H6B4
Chr Location

11q24.1; chr11:123069872-123195248 (-) GRCh38

Alliance of Genome Resources

Clmp stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: CLMP
Gene Tree

Clmp

Diseases

1 with human CLMP associations

				Human Disease	Mouse Models
				short bowel syndrome IDs short bowel syndrome DOID:10605 MESH:D012778 NCI:C99059 UMLS_CUI:C0036992

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

29 phenotypes from 3 alleles in 3 genetic backgrounds
13 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

79
Endonuclease-mediated

2
Gene trapped

65
Targeted

9
Transgenic

3
Incidental Mutations

APF , CvDC
Find Mice (IMSR)

199 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a targeted null allele exhibit reduced viability, bilateral hydronephrosis, increased mean systolic blood pressure, and exhibit several blood chemistry and neurological anomalies. Null mice are samller than controls.

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All GO Annotations

7
GO References

3

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development	DNA-templated transcription

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

798
Tissues

29
cDNA Data

64
Literature Summary

7

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA CLMP

Xenbase clmp

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Clmp interacts with 334 markers (Mir1a-1, Mir1a-2, Mir7-1, ...) View All

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All Sequences

48
RefSeq

7
UniProt

2
CCDS

CCDS23082.1

Ensembl

ENSMUSG00000032024 (Evidence)
NCBI Gene

71566

			Length	Strain/Species	Flank
genomic	ENSMUSG00000032024	Ensembl Gene Model \| MGI Sequence Detail	99358	C57BL/6J	± kb
transcript	ENSMUST00000034522	Ensembl \| MGI Sequence Detail	4154	Not Applicable
polypeptide	ENSMUSP00000034522	Ensembl \| MGI Sequence Detail	373	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000003605 adipocyte adhesion molecule

(term hierarchy)
InterPro Domains

IPR042454 CXADR-like membrane protein

IPR007110 Immunoglobulin-like domain

IPR036179 Immunoglobulin-like domain superfamily

IPR013783 Immunoglobulin-like fold

IPR003599 Immunoglobulin subtype

IPR003598 Immunoglobulin subtype 2

IPR013106 Immunoglobulin V-set domain

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All nucleic 67

cDNA 66

Other 1

Microarray probesets 5

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MGI:2143334

Summaries

All 44

Developmental Gene Expression 7

Gene Ontology 3

Phenotypes 13
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:340886 Luissint AC, et al., CXADR-Like Membrane Protein regulates colonic epithelial cell proliferation and prevents tumor growth. Gastroenterology. 2023 Sep 14;

TSS for Clmp:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr84456	Chr9:40597250-40597272 (+)	3 bp
Tssr84457	Chr9:40597284-40597295 (+)	32 bp
Tssr84458	Chr9:40597298-40597355 (+)	69 bp
Tssr84459	Chr9:40599138-40599149 (+)	1,886 bp
Tssr84460	Chr9:40607413-40607416 (+)	10,157 bp
Tssr84461	Chr9:40621405-40621411 (+)	24,150 bp
Tssr84462	Chr9:40642250-40642274 (+)	45,004 bp
Tssr84463	Chr9:40642299-40642310 (+)	45,047 bp
Tssr84464	Chr9:40682063-40682088 (+)	84,818 bp
Tssr84465	Chr9:40685709-40685725 (+)	88,459 bp
Tssr84466	Chr9:40688058-40688081 (+)	90,812 bp
Tssr84467	Chr9:40691630-40691661 (+)	94,388 bp
Tssr84468	Chr9:40692372-40692386 (+)	95,121 bp
Tssr84469	Chr9:40692424-40692473 (+)	95,191 bp
Tssr84470	Chr9:40693573-40693618 (+)	96,338 bp
Tssr84471	Chr9:40693700-40693723 (+)	96,454 bp
Tssr84472	Chr9:40696129-40696142 (+)	98,878 bp
Tssr84473	Chr9:40696233-40696252 (+)	98,985 bp
Tssr84474	Chr9:40696270-40696281 (+)	99,018 bp
Tssr84475	Chr9:40696288-40696317 (+)	99,045 bp
Tssr84476	Chr9:40696365-40696404 (+)	99,127 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/21/2023 MGI 6.22