About   Help   FAQ
Arhgap42 Gene Detail
Summary
  • Symbol
    Arhgap42
  • Name
    Rho GTPase activating protein 42
  • Synonyms
    9030420J04Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1918794
    NCBI Gene: 71544
  • Alliance
    genome feature page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:8994330-9239106 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 2.46 cM, cytoband A1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    8192 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1918794
 protein coding gene Chr9:8992508-9239106 (-)
129S1/SvImJ ENSMUSG00200022642
 protein coding gene Chr9:5851035-6096509 (-)
A/J ENSMUSG00195018417
 protein coding gene Chr9:5762865-6007681 (-)
AKR/J ENSMUSG00220018381
 protein coding gene Chr9:5733166-5978214 (-)
BALB/cJ ENSMUSG00180011542
 protein coding gene Chr9:5895273-6140092 (-)
C3H/HeJ ENSMUSG00175023967
 protein coding gene Chr9:5819507-6064299 (-)
C57BL/6NJ ENSMUSG00215005328
 protein coding gene Chr9:5833430-6078264 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031770
 protein coding gene Chr9:5122701-5369600 (-)
CAST/EiJ ENSTCUG00005007282
 protein coding gene Chr9:5850303-6100197 (-)
CBA/J ENSMUSG00210010579
 protein coding gene Chr9:5880496-6125288 (-)
DBA/2J ENSMUSG00185004968
 protein coding gene Chr9:5963231-6208011 (-)
FVB/NJ ENSMUSG00205006820
 protein coding gene Chr9:5935742-6163335 (-)
JF1/MsJ ENSUMUG00000007682
 protein coding gene Chr9:5951229-6200176 (-)
LP/J ENSMUSG00230003540
 protein coding gene Chr9:6392363-6637826 (-)
NOD/ShiLtJ ENSMUSG00190021788
 protein coding gene Chr9:5871440-6116232 (-)
NZO/HlLtJ ENSMUSG00225016307
 protein coding gene Chr9:6302797-6547592 (-)
PWK/PhJ ENSLUMG00010006400
 protein coding gene Chr9:5934153-6183730 (-)
SPRET/EiJ ENSMSPG00010005562
 protein coding gene Chr9:5994558-6257639 (-)
WSB/EiJ ENSIUOG00005007221
 protein coding gene Chr9:5636180-5881075 (-)



Homology
more
  • Human Ortholog
    ARHGAP42, Rho GTPase activating protein 42
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ARHGAP42, Rho GTPase activating protein 42
  • Synonyms
    AD031, GRAF3, TMEM133
  • Links
    NCBI Gene ID: 143872
    UniProt: A6NI28

  • Chr Location
    11q22.1; chr11:100687288-100993941 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 2 alleles in 2 genetic backgrounds
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a hypomorphic allele exhibit hypertension and increased vascular smooth muscle contractility.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    12
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    597
  • cDNA Data
    41
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000050730 Ensembl Gene Model | MGI Sequence Detail 244777 C57BL/6J ±  kb
    transcript ENSMUST00000093893 Ensembl | MGI Sequence Detail 6116 Not Applicable  
    polypeptide ENSMUSP00000091419 Ensembl | MGI Sequence Detail 841 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 42
      cDNA 42

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:3034272
    References
    more
    • Summaries
      All 39
      Gene Ontology 6
      Phenotypes 10
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory