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Depp1 Gene Detail
Summary
  • Symbol
    Depp1
  • Name
    DEPP1 autophagy regulator
  • Synonyms
    8430408G22Rik, Depp
  • Feature Type
    protein coding gene
  • IDs
    MGI:1918730
    NCBI Gene: 213393
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:116627645-116629808 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 53.83 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    107 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1918730
 protein coding gene Chr6:116627570-116629808 (+)
129S1/SvImJ MGP_129S1SvImJ_G0031175
 protein coding gene Chr6:119339753-119341969 (+)
A/J MGP_AJ_G0031145
 protein coding gene Chr6:114766668-114768853 (+)
AKR/J MGP_AKRJ_G0031075
 protein coding gene Chr6:117852598-117854814 (+)
BALB/cJ MGP_BALBcJ_G0031155
 protein coding gene Chr6:114563225-114565410 (+)
C3H/HeJ MGP_C3HHeJ_G0030555
 protein coding gene Chr6:66441455-66443646 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031613
 protein coding gene Chr6:122410770-122412955 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028778
 protein coding gene Chr6:111771801-111773977 (+)
CAST/EiJ MGP_CASTEiJ_G0030262
 protein coding gene Chr6:118232941-118235146 (+)
CBA/J MGP_CBAJ_G0030839
 protein coding gene Chr6:127222582-127224773 (+)
DBA/2J MGP_DBA2J_G0030995
 protein coding gene Chr6:113683174-113685390 (+)
FVB/NJ MGP_FVBNJ_G0030947
 protein coding gene Chr6:112858635-112860853 (+)
LP/J MGP_LPJ_G0031073
 protein coding gene Chr6:119369134-119371350 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0030981
 protein coding gene Chr6:131371492-131373708 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0031642
 protein coding gene Chr6:117887129-117889345 (+)
PWK/PhJ MGP_PWKPhJ_G0029978
 protein coding gene Chr6:112698983-112701174 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029806
 protein coding gene Chr6:116624258-116626476 (+)
WSB/EiJ MGP_WSBEiJ_G0030345
 protein coding gene Chr6:118156912-118159130 (+)



Homology
more
  • Human Ortholog
    DEPP1, DEPP autophagy regulator 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DEPP1, DEPP autophagy regulator 1
  • Synonyms
    C10orf10, DEPP, FIG, Fseg
  • Links
    NCBI Gene ID: 11067
    neXtProt AC: NX_Q9NTK1
    UniProt: Q9NTK1

  • Chr Location
    10q11.21; chr10:44970981-44978809 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    2 phenotype references
Mice homozygous for a knock-in allele are viable and fertile and display normal heart and blood vessel development.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    9
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    743
  • Tissues
    37
  • cDNA Data
    71
  • Literature Summary
    5
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 213393 NCBI Gene Model | MGI Sequence Detail 2164 C57BL/6J ±  kb
transcript NM_145980 RefSeq | MGI Sequence Detail 1317 C57BL/6  
polypeptide Q8K2F3 UniProt | EBI | MGI Sequence Detail 205 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 71
    cDNA 71

    Microarray probesets 4
References
more
  • Summaries
    All 29
    Developmental Gene Expression 5
    Gene Ontology 4
    Phenotypes 2
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:326566 Guo F, et al., DEPP Deficiency Contributes to Browning of White Adipose Tissue. Int J Mol Sci. 2022 Jun 12;23(12)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/19/2023
MGI 6.22 		The Jackson Laboratory