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Bcor Gene Detail
Summary
  • Symbol
    Bcor
  • Name
    BCL6 interacting corepressor
  • Synonyms
    2900008C10Rik, 5830466J11Rik, 8430401K06Rik, D930024N20Rik, mKIAA1575
  • Feature Type
    protein coding gene
  • IDs
    MGI:1918708
    NCBI Gene: 71458
  • Alliance
    gene page
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:11902979-12026594 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 6.83 cM, cytoband A1.2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    177 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1918708
 protein coding gene ChrX:11902976-12026769 (-)
129S1/SvImJ MGP_129S1SvImJ_G0035566
 protein coding gene ChrX:6831357-6966120 (-)
A/J MGP_AJ_G0035544
 protein coding gene ChrX:6953914-7081370 (-)
AKR/J MGP_AKRJ_G0035476
 protein coding gene ChrX:7111063-7263573 (-)
BALB/cJ MGP_BALBcJ_G0035537
 protein coding gene ChrX:6813303-6939765 (-)
C3H/HeJ MGP_C3HHeJ_G0035253
 protein coding gene ChrX:6948967-7079076 (-)
C57BL/6NJ MGP_C57BL6NJ_G0036066
 protein coding gene ChrX:7020509-7150979 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032936
 protein coding gene ChrX:5893814-6016501 (-)
CAST/EiJ MGP_CASTEiJ_G0034545
 protein coding gene ChrX:6690876-6820768 (-)
CBA/J MGP_CBAJ_G0035222
 protein coding gene ChrX:7376914-7518074 (-)
DBA/2J MGP_DBA2J_G0035375
 protein coding gene ChrX:6802423-6927647 (-)
FVB/NJ MGP_FVBNJ_G0035322
 protein coding gene ChrX:6629712-6754914 (-)
LP/J MGP_LPJ_G0035457
 protein coding gene ChrX:7021769-7152211 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0035365
 protein coding gene ChrX:7301904-7437497 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0036078
 protein coding gene ChrX:6749259-6881180 (-)
PWK/PhJ MGP_PWKPhJ_G0034246
 protein coding gene ChrX:6299373-6426264 (-)
SPRET/EiJ MGP_SPRETEiJ_G0034087
 protein coding gene ChrX:6853215-6985584 (-)
WSB/EiJ MGP_WSBEiJ_G0034681
 protein coding gene ChrX:6811637-6942682 (-)



Homology
more
  • Human Ortholog
    BCOR, BCL6 corepressor
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    BCOR, BCL6 corepressor
  • Synonyms
    ANOP2, MAA2, MCOPS2
  • Links
    NCBI Gene ID: 54880
    neXtProt AC: NX_Q6W2J9
    UniProt: Q6W2J9

  • Chr Location
    Xp11.4; chrX:40049815-40177329 (-)  GRCh38
  • Human Ortholog
    BCORP1, BCL6 corepressor pseudogene 1
  • Synonyms
    BCORL2
  • Links
    NCBI Gene ID: 286554
    UniProt: Q8N888

  • Chr Location
    Yq11.222; chrY:19455431-19567092 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Bcor mouse models; 8 with human BCOR associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    53 phenotypes from 6 alleles in 8 genetic backgrounds
    24 images
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Male chimeras hemizygous for either of two different gene trapped alleles die by E9.5 exhibiting anomalies in somite formation and heart looping, forebrain fusion, and microcephaly. Hemizygosity for other gene trapped alleles can cause patterning and embryo turning defects or abnormal gastrulation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    35
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    963
  • Tissues
    112
  • cDNA Data
    108
  • Literature Summary
    8
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000040363 Ensembl Gene Model | MGI Sequence Detail 123616 C57BL/6J ±  kb
    transcript ENSMUST00000115513 Ensembl | MGI Sequence Detail 6941 Not Applicable  
    polypeptide ENSMUSP00000111175 Ensembl | MGI Sequence Detail 1759 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 115
      cDNA 109
      Primer pair 6

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:1920187, MGI:1923325, MGI:2444213
    References
    more
    • Summaries
      All 61
      Developmental Gene Expression 8
      Diseases 1
      Gene Ontology 8
      Phenotypes 20
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:329268 Langouet M, et al., Mutations in BCOR, a co-repressor of CRX/OTX2, are associated with early-onset retinal degeneration. Sci Adv. 2022 Sep 9;8(36):eabh2868
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory