Sft2d1 MGI Mouse Gene Detail - MGI:1918689

Symbol

Sft2d1
Name

SFT2 domain containing 1
Synonyms

5630401J11Rik

Feature Type

protein coding gene
IDs

MGI:1918689
NCBI Gene: 106489
Alliance

gene page
Transcription Start Sites

1 TSS

Sequence Map

Chr17:8529934-8546274 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 17, 4.92 cM
Mapping Data

1 experiment

SNPs within 2kb

172 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1918689	protein coding gene	Chr17:8529920-8546274 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0023132	protein coding gene	Chr17:5782346-5866657 (+)
A/J	MGP_AJ_G0023100	protein coding gene	Chr17:5811469-5893646 (+)
AKR/J	MGP_AKRJ_G0023065	protein coding gene	Chr17:5490036-5580227 (+)
BALB/cJ	MGP_BALBcJ_G0023100	protein coding gene	Chr17:5613680-5692419 (+)
C3H/HeJ	MGP_C3HHeJ_G0022863	protein coding gene	Chr17:5761276-5844354 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0023544	protein coding gene	Chr17:6059949-6158018 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0021062	protein coding gene	Chr17:8473599-8551707 (-)
CAST/EiJ	MGP_CASTEiJ_G0022378	protein coding gene	Chr17:5744058-5822828 (+)
CBA/J	MGP_CBAJ_G0022835	protein coding gene	Chr17:6269415-6356479 (+)
DBA/2J	MGP_DBA2J_G0022968	protein coding gene	Chr17:5479866-5559348 (+)
FVB/NJ	MGP_FVBNJ_G0022937	protein coding gene	Chr17:5405458-5488592 (+)
LP/J	MGP_LPJ_G0023039	protein coding gene	Chr17:5605924-5696439 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0022958	protein coding gene	Chr17:6015829-6100500 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0023569	protein coding gene	Chr17:5763269-5857048 (+)
PWK/PhJ	MGP_PWKPhJ_G0022126	protein coding gene	Chr17:5107714-5193578 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0021955	protein coding gene	Chr17:5037279-5117763 (+)
WSB/EiJ	MGP_WSBEiJ_G0022434	protein coding gene	Chr17:6071757-6158258 (+)

Human Ortholog

SFT2D1, SFT2 domain containing 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SFT2D1, SFT2 domain containing 1
Synonyms

C6orf83, pRGR1
Links

HGNC:21102

NCBI Gene ID: 113402

neXtProt AC: NX_Q8WV19

UniProt: Q8WV19
Chr Location

6q27; chr6:166319728-166342576 (-) GRCh38

MGI Vertebrate Homology

Sft2d1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: SFT2D1
Gene Tree

Sft2d1

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References

6 with disease annotations

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Phenotype Summary

330 phenotype references

All Mutations and Alleles

1
Radiation induced

1
Genomic Mutations

1 involving Sft2d1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

14 strains or lines available

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All GO Annotations

6
GO References

4

Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

68

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase sft2d1

ZFIN sft2d1

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All Sequences

50
RefSeq

6
UniProt

1
CCDS

CCDS49945.1

Ensembl

ENSMUSG00000073468 (Evidence)
NCBI Gene

106489

			Length	Strain/Species	Flank
genomic	ENSMUSG00000073468	Ensembl Gene Model \| MGI Sequence Detail	16341	C57BL/6J	± kb
transcript	ENSMUST00000154553	Ensembl \| MGI Sequence Detail	1049	Not Applicable
polypeptide	ENSMUSP00000117294	Ensembl \| MGI Sequence Detail	159	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000014767 vesicle transport protein SFT2A

(term hierarchy)

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All nucleic 68

cDNA 68

Microarray probesets 5

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MGI:2146762

Summaries

All 354

Diseases 6

Gene Ontology 4

Phenotypes 330
Earliest

J:30229 Davisson MT, et al., Segmental trisomy as a mouse model for Down syndrome. Prog Clin Biol Res. 1993;384:117-33
Latest

J:346702 Colombi I, et al., Heterogeneous subpopulations of GABA(A)R-responding neurons coexist across neuronal network scales and developmental stages in health and disease. iScience. 2024 Apr 19;27(4):109438

TSS for Sft2d1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr142527	Chr17:8529914-8529925 (+)	-14 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/23/2024 MGI 6.23