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Tmem74b Gene Detail
Summary
  • Symbol
    Tmem74b
  • Name
    transmembrane protein 74B
  • Synonyms
    5430405G05Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1918629
    NCBI Gene: 108832
  • Alliance
    genome feature page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:151543928-151554077 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 74.83 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    315 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1918629
 protein coding gene Chr2:151543294-151558665 (+)
129S1/SvImJ ENSMUSG00200026011
 protein coding gene Chr2:148448559-148458871 (+)
A/J ENSMUSG00195020226
 protein coding gene Chr2:148728455-148738600 (+)
AKR/J ENSMUSG00220041990
 protein coding gene Chr2:148052057-148062204 (+)
BALB/cJ ENSMUSG00180042545
 protein coding gene Chr2:148208188-148218339 (+)
C3H/HeJ ENSMUSG00175037985
 protein coding gene Chr2:148954473-148964624 (+)
C57BL/6NJ ENSMUSG00215017674
 protein coding gene Chr2:148386742-148396889 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024439
 protein coding gene Chr2:143600266-143610522 (+)
CAST/EiJ ENSTCUG00005039581
 protein coding gene Chr2:147321242-147331537 (+)
CBA/J ENSMUSG00210040344
 protein coding gene Chr2:148890977-148901124 (+)
DBA/2J ENSMUSG00185046254
 protein coding gene Chr2:148546782-148556929 (+)
FVB/NJ ENSMUSG00205020462
 protein coding gene Chr2:147647969-147658118 (+)
JF1/MsJ ENSUMUG00000044688
 protein coding gene Chr2:148230105-148240306 (+)
LP/J ENSMUSG00230032638
 protein coding gene Chr2:150201058-150211366 (+)
NOD/ShiLtJ ENSMUSG00190030992
 protein coding gene Chr2:148329788-148339979 (+)
NZO/HlLtJ ENSMUSG00225004591
 protein coding gene Chr2:158234940-158245086 (+)
PWK/PhJ ENSLUMG00010038187
 protein coding gene Chr2:148201682-148211846 (+)
SPRET/EiJ ENSMSPG00010023807
 protein coding gene Chr2:150928471-150933847 (+)
WSB/EiJ ENSIUOG00005044403
 protein coding gene Chr2:148063531-148073837 (+)



Homology
more
  • Human Ortholog
    TMEM74B, transmembrane protein 74B
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TMEM74B, transmembrane protein 74B
  • Synonyms
    C20orf46
  • Links
    NCBI Gene ID: 55321
    UniProt: Q9NUR3

  • Chr Location
    20p13; chr20:1180561-1189409 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotype references
  • All Mutations and Alleles
    4
  • Chemically induced (other)
    1
  • Radiation induced
    1
  • Targeted
    2
  • Genomic Mutations
    2 involving Tmem74b
  • Incidental Mutations
    APF
  • Find Mice (IMSR)
    7 strains or lines available
Gene Ontology
(GO)
Classifications
less
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

No experimental evidence to support Biological Process annotation, following literature review. See J:73796.
Cellular Component

No experimental evidence to support Cellular Component annotation, following literature review. See J:73796.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    599
  • Tissues
    2
  • cDNA Data
    9
  • Literature Summary
    1
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000044364 Ensembl Gene Model | MGI Sequence Detail 10150 C57BL/6J ±  kb
transcript ENSMUST00000060196 Ensembl | MGI Sequence Detail 1435 Not Applicable  
polypeptide ENSMUSP00000060017 Ensembl | MGI Sequence Detail 232 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    2 Sequences
  • InterPro Domains
    IPR029695 Transmembrane protein 74-like
Molecular
Reagents
less
  • All nucleic 9
    cDNA 9

    Microarray probesets 2
References
more
  • Summaries
    All 27
    Developmental Gene Expression 1
    Phenotypes 7
  • Earliest
    J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory