Mfap3l Gene Detail

Summary

• Symbol
  Mfap3l
• Name
  microfibrillar-associated protein 3-like
• Synonyms
  4933428A15Rik, 5430405D20Rik, mKIAA0626, NYD-sp9

• Feature Type
  protein coding gene
• IDs
  MGI:1918556
  NCBI Gene: 71306
• Alliance
  gene page
• Transcription Start Sites
  13 TSS

Location &
Maps

• Sequence Map
  Chr8:61085861-61129763 bp, + strand

  From Ensembl annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 8, 30.86 cM, cytoband B3.2
• Mapping Data
  3 experiments

Strain
Comparison

• SNPs within 2kb
  1256 from dbSNP Build 142
• Strain Annotations
  18

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1918556	protein coding gene	Chr8:61085859-61129765 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0033630	protein coding gene	Chr8:60517086-60561583 (+)
A/J	MGP_AJ_G0033612	protein coding gene	Chr8:57940755-57984555 (+)
AKR/J	MGP_AKRJ_G0033537	protein coding gene	Chr8:59602428-59647317 (+)
BALB/cJ	MGP_BALBcJ_G0033608	protein coding gene	Chr8:58205497-58250949 (+)
C3H/HeJ	MGP_C3HHeJ_G0033318	protein coding gene	Chr8:60274760-60320019 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0034125	protein coding gene	Chr8:62835311-62880437 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0031073	protein coding gene	Chr8:53215533-53259088 (+)
CAST/EiJ	MGP_CASTEiJ_G0032643	protein coding gene	Chr8:59684502-59727496 (+)
CBA/J	MGP_CBAJ_G0033296	protein coding gene	Chr8:65109632-65155810 (+)
DBA/2J	MGP_DBA2J_G0033450	protein coding gene	Chr8:57697536-57741073 (+)
FVB/NJ	MGP_FVBNJ_G0033391	protein coding gene	Chr8:57017340-57061107 (+)
LP/J	MGP_LPJ_G0033538	protein coding gene	Chr8:60481346-60524878 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0033435	protein coding gene	Chr8:67231110-67280540 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0034143	protein coding gene	Chr8:59862890-59908481 (+)
PWK/PhJ	MGP_PWKPhJ_G0032352	protein coding gene	Chr8:57011909-57055794 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0032188	protein coding gene	Chr8:58840578-58885457 (+)
WSB/EiJ	MGP_WSBEiJ_G0032760	protein coding gene	Chr8:60180121-60228929 (+)

Homology

• Human Ortholog
  MFAP3L, microfibril associated protein 3 like

• Vertebrate Orthologs
  3

Vertebrate Orthology Source

Alliance of Genome Resources

• Human Ortholog
  MFAP3L, microfibril associated protein 3 like
  
• Synonyms
  NYD-sp9
• Links
  HGNC:29083

  NCBI Gene ID: 9848

  UniProt: O75121

  
  
• Chr Location
  4q33; chr4:169986597-170033031 (-)  GRCh38

---

• MGI Vertebrate Homology
  Mfap3l stringent orthology
  1 human;1 mouse;1 rat;1 zebrafish
  
• HCOP
  vertebrate homology predictions: MFAP3L
• Gene Tree
  Mfap3l
  

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  5 phenotype references
  

• All Mutations and Alleles
  4
• Chemically induced (other)
  1
• Endonuclease-mediated
  1
• Targeted
  2
• Genomic Mutations
  1 involving Mfap3l
• Incidental Mutations
  Mutagenetix , APF
• Find Mice (IMSR)
  15 strains or lines available

Gene Ontology
(GO)
Classifications

• All GO Annotations
  20
• GO References
  5

Expression

• Assay Results
  733
• Tissues
  7
• cDNA Data
  30
• Literature Summary
  1

Images

Tissue x Stage Matrix

• Other Mouse Links
  Allen Institute
  GEO
  Expression Atlas
• Other Vertebrate Links
  Xenbase mfap3l

Sequences &
Gene Models

• All Sequences
  48
• RefSeq
  8
• UniProt
  1
• CCDS
  CCDS22321.1, CCDS80877.1

• Ensembl
  ENSMUSG00000031647 (Evidence)
• NCBI Gene
  71306

Representative Sequences			Length	Strain/Species
genomic	ENSMUSG00000031647	Ensembl Gene Model | MGI Sequence Detail	43903	C57BL/6J
transcript	ENSMUST00000161702	Ensembl | MGI Sequence Detail	2215	Not Applicable
polypeptide	ENSMUSP00000124330	Ensembl | MGI Sequence Detail	409	Not Applicable

Protein
Information

• UniProt
  1 Sequence
• Protein Ontology
  PR:000010363 microfibrillar-associated protein 3-like
  (term hierarchy)
• InterPro Domains
  IPR013098 Immunoglobulin I-set
  IPR007110 Immunoglobulin-like domain
  IPR036179 Immunoglobulin-like domain superfamily
  IPR013783 Immunoglobulin-like fold
  IPR003599 Immunoglobulin subtype
  IPR003598 Immunoglobulin subtype 2
• GlyGen
  Q9D3X9 5 sites, 4 N-linked glycans (5 sites)

Molecular
Reagents

• All nucleic 31

  cDNA 31

  
  

  Microarray probesets 6

Other
Accession IDs

MGI:1918658, MGI:2142558, MGI:2142769

References

• Summaries
  All 33

  Developmental Gene Expression 1

  Gene Ontology 5

  Phenotypes 5
• Earliest
  J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
• Latest
  J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

TSS for Mfap3l:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr77454	Chr8:61085840-61085849 (+)	-16 bp
Tssr77455	Chr8:61085852-61085870 (+)	0 bp
Tssr77456	Chr8:61085890-61085939 (+)	54 bp
Tssr77457	Chr8:61093413-61093423 (+)	7,557 bp
Tssr77458	Chr8:61093887-61093907 (+)	8,036 bp
Tssr77459	Chr8:61108534-61108556 (+)	22,684 bp
Tssr77460	Chr8:61108579-61108596 (+)	22,727 bp
Tssr77461	Chr8:61124607-61124619 (+)	38,752 bp
Tssr77462	Chr8:61126394-61126400 (+)	40,536 bp
Tssr77463	Chr8:61127388-61127410 (+)	41,538 bp
Tssr77464	Chr8:61127534-61127547 (+)	41,680 bp
Tssr77465	Chr8:61127580-61127591 (+)	41,725 bp
Tssr77466	Chr8:61127605-61127617 (+)	41,750 bp