About   Help   FAQ
Dlg5 Gene Detail
Summary
  • Symbol
    Dlg5
  • Name
    discs large MAGUK scaffold protein 5
  • Synonyms
    4933429D20Rik, mKIAA0583
  • Feature Type
    protein coding gene
  • IDs
    MGI:1918478
    NCBI Gene: 71228
  • Alliance
    genome feature page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:24184021-24295988 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 14.26 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3349 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1918478
 protein coding gene Chr14:24184021-24295988 (-)
129S1/SvImJ ENSMUSG00200013434
 protein coding gene Chr14:15986065-16098055 (-)
A/J ENSMUSG00195020957
 protein coding gene Chr14:17064579-17176598 (-)
AKR/J ENSMUSG00220023402
 protein coding gene Chr14:16168325-16280335 (-)
BALB/cJ ENSMUSG00180037371
 protein coding gene Chr14:16156542-16268559 (-)
C3H/HeJ ENSMUSG00175022083
 protein coding gene Chr14:16224335-16336352 (-)
C57BL/6NJ ENSMUSG00215018270
 protein coding gene Chr14:16462865-16574893 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019014
 protein coding gene Chr14:16871896-16986226 (-)
CAST/EiJ ENSTCUG00005028325
 protein coding gene Chr14:16327330-16438947 (-)
CBA/J ENSMUSG00210026396
 protein coding gene Chr14:16459154-16571154 (-)
DBA/2J ENSMUSG00185040956
 protein coding gene Chr14:20744242-20856250 (-)
FVB/NJ ENSMUSG00205026076
 protein coding gene Chr14:16278025-16390041 (-)
JF1/MsJ ENSUMUG00000020842
 protein coding gene Chr14:27951162-28063380 (-)
LP/J ENSMUSG00230034984
 protein coding gene Chr14:28025742-28137729 (-)
NOD/ShiLtJ ENSMUSG00190031178
 protein coding gene Chr14:16460201-16572275 (-)
NZO/HlLtJ ENSMUSG00225036953
 protein coding gene Chr14:22249804-22361379 (-)
PWK/PhJ ENSLUMG00010021078
 protein coding gene Chr14:4601487-4713500 (-)
SPRET/EiJ ENSMSPG00010026927
 protein coding gene Chr14:18110692-18226996 (-)
WSB/EiJ ENSIUOG00005029342
 protein coding gene Chr14:16302313-16419119 (-)



Homology
more
  • Human Ortholog
    DLG5, discs large MAGUK scaffold protein 5
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DLG5, discs large MAGUK scaffold protein 5
  • Synonyms
    LP-DLG, PDLG, P-DLG5, YUVOB
  • Links
    NCBI Gene ID: 9231
    UniProt: Q8TDM6

  • Chr Location
    10q22.3; chr10:77790778-77940736 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    27 phenotypes from 2 alleles in 2 genetic backgrounds
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit growth retardation, hydroencephaly, abnormal brain morphology, abnormal neurogenesis, kidney cysts, ureter defects, and abnormal kidney morphology.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    62
  • GO References
    14
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    690
  • Tissues
    46
  • cDNA Data
    109
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 71228 NCBI Gene Model | MGI Sequence Detail 111968 C57BL/6J ±  kb
    transcript NM_001163513 RefSeq | MGI Sequence Detail 7878 C57BL/6  
    polypeptide E9Q9R9 UniProt | EBI | MGI Sequence Detail 1921 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 111
      cDNA 110
      Primer pair 1
      Antibodies 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:2145886
    References
    more
    • Summaries
      All 48
      Developmental Gene Expression 6
      Gene Ontology 14
      Phenotypes 15
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory