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Otud1 Gene Detail
Summary
  • Symbol
    Otud1
  • Name
    OTU domain containing 1
  • Synonyms
    4933428L19Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1918448
    NCBI Gene: 71198
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:19662563-19665394 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 2, 13.78 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    12 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1918448
protein coding gene Chr2:19662542-19666090 (+)
129S1/SvImJ MGP_129S1SvImJ_G0025384
protein coding gene Chr2:17411051-17413882 (+)
A/J MGP_AJ_G0025362
protein coding gene Chr2:16689566-16692403 (+)
AKR/J MGP_AKRJ_G0025330
protein coding gene Chr2:17274828-17277665 (+)
BALB/cJ MGP_BALBcJ_G0025357
protein coding gene Chr2:16748804-16751635 (+)
C3H/HeJ MGP_C3HHeJ_G0025117
protein coding gene Chr2:17180233-17183064 (+)
C57BL/6NJ MGP_C57BL6NJ_G0025800
protein coding gene Chr2:17877191-17880022 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0023215
protein coding gene Chr2:16060168-16063003 (+)
CAST/EiJ MGP_CASTEiJ_G0024581
protein coding gene Chr2:17135624-17138470 (+)
CBA/J MGP_CBAJ_G0025096
protein coding gene Chr2:18639864-18642695 (+)
DBA/2J MGP_DBA2J_G0025228
protein coding gene Chr2:16630070-16632907 (+)
FVB/NJ MGP_FVBNJ_G0025191
protein coding gene Chr2:16434842-16437673 (+)
LP/J MGP_LPJ_G0025315
protein coding gene Chr2:17236477-17239308 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0025222
protein coding gene Chr2:18587294-18590126 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0025858
protein coding gene Chr2:17209105-17211936 (+)
PWK/PhJ MGP_PWKPhJ_G0024330
protein coding gene Chr2:16508904-16511748 (+)
SPRET/EiJ MGP_SPRETEiJ_G0024130
protein coding gene Chr2:17340912-17343743 (+)
WSB/EiJ MGP_WSBEiJ_G0024651
protein coding gene Chr2:17280997-17283833 (+)



Homology
more
  • Human Ortholog
    OTUD1, OTU deubiquitinase 1
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    OTUD1, OTU deubiquitinase 1
  • Synonyms
    DUBA7, OTDC1
  • Links
    NCBI Gene ID: 220213
    neXtProt AC: NX_Q5VV17
    UniProt: Q5VV17

  • Chr Location
    10p12.2; chr10:23439075-23442377 (+)  GRCh38

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele are more resistant to lethal HSV-1 and VSV infection, but are more susceptible to LPS stimulation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

No experimental evidence to support Cellular Component annotation, following literature review. See J:73796.
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000043415 Ensembl Gene Model | MGI Sequence Detail 2832 C57BL/6J ±  kb
    transcript ENSMUST00000052168 Ensembl | MGI Sequence Detail 2832 Not Applicable  
    polypeptide ENSMUSP00000100617 Ensembl | MGI Sequence Detail 454 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 21
      Genomic 1
      cDNA 19
      Primer pair 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 37
      Developmental Gene Expression 3
      Gene Ontology 4
      Phenotypes 11
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:343247 Zheng S, et al., OTUD1 ameliorates cerebral ischemic injury through inhibiting inflammation by disrupting K63-linked deubiquitination of RIP2. J Neuroinflammation. 2023 Nov 27;20(1):281

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    05/14/2024
    MGI 6.23
    The Jackson Laboratory