Agbl4 MGI Mouse Gene Detail - MGI:1918244 - ATP/GTP binding protein-like 4

Symbol

Agbl4
Name

ATP/GTP binding protein-like 4
Synonyms

4930578N11Rik, 4931433A01Rik, Ccp6

Feature Type

protein coding gene
IDs

MGI:1918244
NCBI Gene: 78933
Alliance

gene page
Transcription Start Sites

12 TSS

Sequence Map

Chr4:110254858-111521521 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 4, 51.43 cM, cytoband C7
Mapping Data

2 experiments

SNPs within 2kb

8704 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1918244	protein coding gene	Chr4:110254823-111521521 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0028577	protein coding gene	Chr4:111195394-112519871 (+)
A/J	MGP_AJ_G0028540	protein coding gene	Chr4:107197461-108435013 (+)
AKR/J	MGP_AKRJ_G0028487	protein coding gene	Chr4:109884546-111137014 (+)
BALB/cJ	MGP_BALBcJ_G0028559	protein coding gene	Chr4:107403428-108660945 (+)
C3H/HeJ	MGP_C3HHeJ_G0028273	protein coding gene	Chr4:110622149-111869875 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0028999	protein coding gene	Chr4:115204913-116572567 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0026290	protein coding gene	Chr4:102475419-103607893 (+)
CAST/EiJ	MGP_CASTEiJ_G0027709	protein coding gene	Chr4:108487340-109736674 (+)
CBA/J	MGP_CBAJ_G0028242	protein coding gene	Chr4:118974666-120358593 (+)
DBA/2J	MGP_DBA2J_G0028390	protein coding gene	Chr4:106824989-108095501 (+)
FVB/NJ	MGP_FVBNJ_G0028358	protein coding gene	Chr4:105679047-106917965 (+)
LP/J	MGP_LPJ_G0028491	protein coding gene	Chr4:111477876-112793811 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0028384	protein coding gene	Chr4:124212573-125748764 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0029035	protein coding gene	Chr4:110114997-111385261 (+)
PWK/PhJ	MGP_PWKPhJ_G0027435	protein coding gene	Chr4:105110524-106339699 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0027259	protein coding gene	Chr4:107522630-108742388 (+)
WSB/EiJ	MGP_WSBEiJ_G0027790	protein coding gene	Chr4:110299131-111612844 (+)

Human Ortholog

AGBL4, AGBL carboxypeptidase 4

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

AGBL4, AGBL carboxypeptidase 4
Synonyms

CCP6
Links

HGNC:25892

NCBI Gene ID: 84871

neXtProt AC: NX_Q5VU57

UniProt: Q5VU57
Chr Location

1p33; chr1:48522511-50023954 (-) GRCh38

MGI Vertebrate Homology

Agbl4 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: AGBL4
Gene Tree

Agbl4

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Phenotype Summary

22 phenotypes from 2 alleles in 2 genetic backgrounds
16 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Chemically induced (other)

2
Endonuclease-mediated

1
Radiation induced

1
Targeted

3
Transposon induced

1
Genomic Mutations

4 involving Agbl4
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

47 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit abnormal platelet morphology and physiology, impaired megakaryopoiesis, increased spleen weight and increased susceptibility to HSV or VACV infection.

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All GO Annotations

30
GO References

11

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

768
Tissues

11
cDNA Data

12
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase agbl4

ZFIN agbl4

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All Sequences

77
RefSeq

22
UniProt

7
CCDS

CCDS51263.1, CCDS51264.1, CCDS71443.1

Ensembl

ENSMUSG00000061298 (Evidence)
NCBI Gene

78933

			Length	Strain/Species	Flank
genomic	ENSMUSG00000061298	Ensembl Gene Model \| MGI Sequence Detail	1266664	C57BL/6J	± kb
transcript	ENSMUST00000097920	Ensembl \| MGI Sequence Detail	1798	Not Applicable
polypeptide	ENSMUSP00000095533	Ensembl \| MGI Sequence Detail	540	Not Applicable

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UniProt

7 Sequences
Protein Ontology

PR:000003826 cytosolic carboxypeptidase 6

(term hierarchy)
EC

3.4.17.-, 3.4.17.24
InterPro Domains

IPR040626 Cytosolic carboxypeptidase, N-terminal

IPR000834 Peptidase M14, carboxypeptidase A

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All nucleic 13

cDNA 12

Primer pair 1

Microarray probesets 6

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MGI:1926183

Summaries

All 42

Developmental Gene Expression 3

Gene Ontology 11

Phenotypes 16
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:343289 Ho KH, et al., Choroid plexuses carry nodal-like cilia that undergo axoneme regression from early adult stage. Dev Cell. 2023 Dec 4;58(23):2641-2651.e6

TSS for Agbl4:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr38370	Chr4:110254885-110254905 (+)	37 bp
Tssr38371	Chr4:110254907-110254960 (+)	76 bp
Tssr38372	Chr4:110254961-110255005 (+)	125 bp
Tssr38373	Chr4:110266759-110266763 (+)	11,903 bp
Tssr38374	Chr4:110441124-110441128 (+)	186,268 bp
Tssr38375	Chr4:110446611-110446614 (+)	191,755 bp
Tssr38376	Chr4:110509817-110509823 (+)	254,962 bp
Tssr1261	Chr4:110544571-110544575 (+)	289,715 bp
Tssr38377	Chr4:110675043-110675047 (+)	420,187 bp
Tssr38378	Chr4:111109729-111109730 (+)	854,872 bp
Tssr38380	Chr4:111268290-111268300 (+)	1,013,437 bp
Tssr1262	Chr4:111372804-111372806 (+)	1,117,947 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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