Eva1c MGI Mouse Gene Detail - MGI:1918217

Symbol

Eva1c
Name

eva-1 homolog C
Synonyms

1700092M14Rik, 4931408A02Rik, Fam176c

Feature Type

protein coding gene
IDs

MGI:1918217
NCBI Gene: 70967
Alliance

gene page
Transcription Start Sites

9 TSS

Sequence Map

Chr16:90623607-90701997 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 16, 52.02 cM, cytoband C3.3
Mapping Data

2 experiments

SNPs within 2kb

5410 from dbSNP Build 142
Strain Annotations

11

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1918217	protein coding gene	Chr16:90623607-90701997 (+)
129S1/SvImJ	no annotation
A/J	MGP_AJ_G0022998	protein coding gene	Chr16:87514061-87594349 (+)
AKR/J	no annotation
BALB/cJ	MGP_BALBcJ_G0023000	protein coding gene	Chr16:88035437-88114937 (+)
C3H/HeJ	MGP_C3HHeJ_G0022761	protein coding gene	Chr16:90715665-90798796 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0023447	protein coding gene	Chr16:94778663-94863257 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020949	protein coding gene	Chr16:85218940-85294295 (+)
CAST/EiJ	no annotation
CBA/J	MGP_CBAJ_G0022730	protein coding gene	Chr16:98815530-98915114 (+)
DBA/2J	no annotation
FVB/NJ	MGP_FVBNJ_G0022838	protein coding gene	Chr16:86542121-86622687 (+)
LP/J	no annotation
NOD/ShiLtJ	MGP_NODShiLtJ_G0022859	protein coding gene	Chr16:103381568-103476676 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0023465	protein coding gene	Chr16:90660466-90741504 (+)
PWK/PhJ	no annotation
SPRET/EiJ	no annotation
WSB/EiJ	MGP_WSBEiJ_G0022332	protein coding gene	Chr16:90894530-90979127 (+)

Human Ortholog

EVA1C, eva-1 homolog C

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

EVA1C, eva-1 homolog C
Synonyms

B18, B19, C21orf63, C21orf64, FAM176C, PRED34, SUE21
Links

HGNC:13239

NCBI Gene ID: 59271

UniProt: P58658
Chr Location

21q22.11; chr21:32411723-32515397 (+) GRCh38

MGI Vertebrate Homology

Eva1c stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: EVA1C
Gene Tree

Eva1c

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References

4 with disease annotations

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
77 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

15
Endonuclease-mediated

5
Gene trapped

1
Spontaneous

1
Targeted

7
Genomic Mutations

8 involving Eva1c
Incidental Mutations

APF
Find Mice (IMSR)

28 strains or lines available

Homozygous mice exhibit an abnormal pupilary reflex in response to dilating drugs.

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All GO Annotations

4
GO References

2

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

No experimental evidence to support Biological Process annotation, following literature review. See J:73796.

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

942
Tissues

184
cDNA Data

11
Literature Summary

7

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

65
RefSeq

18
UniProt

7
CCDS

CCDS28319.1, CCDS57038.1, CCDS84261.1, CCDS88968.1

Ensembl

ENSMUSG00000039903 (Evidence)
NCBI Gene

70967

			Length	Strain/Species	Flank
genomic	70967	NCBI Gene Model \| MGI Sequence Detail	78391	C57BL/6J	± kb
transcript	NM_001199210	RefSeq \| MGI Sequence Detail	2366	C57BL/6
polypeptide	P58659	UniProt \| EBI \| MGI Sequence Detail	440	Not Applicable

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UniProt

7 Sequences
Protein Ontology

PR:000032508 protein FAM176C

(term hierarchy)
InterPro Domains

IPR000922 D-galactoside/L-rhamnose binding SUEL lectin domain

IPR043159 D-galactoside/L-rhamnose binding SUEL lectin domain superfamily

IPR039500 EVA1 domain

IPR052461 EVA1 family of programmed cell death regulators
GlyGen

P58659 3 sites, 1 N-linked glycan (1 site)

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All nucleic 15

cDNA 11

Primer pair 3

Other 1

Microarray probesets 3

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MGI:1920793

Summaries

All 105

Developmental Gene Expression 7

Diseases 4

Gene Ontology 2

Phenotypes 77
Earliest

J:42265 Huang TT, et al., Superoxide-mediated cytotoxicity in superoxide dismutase-deficient fetal fibroblasts. Arch Biochem Biophys. 1997 Aug 15;344(2):424-32
Latest

J:361105 Tateossian H, et al., DYRK1A kinase triplication is the major cause of Otitis Media in Down Syndrome. Elife. 2025;

TSS for Eva1c:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr139311	Chr16:90623630-90623645 (+)	31 bp
Tssr139312	Chr16:90626969-90626990 (+)	3,373 bp
Tssr139313	Chr16:90627004-90627021 (+)	3,406 bp
Tssr139314	Chr16:90627293-90627313 (+)	3,696 bp
Tssr139315	Chr16:90627718-90627766 (+)	4,135 bp
Tssr139316	Chr16:90628017-90628038 (+)	4,421 bp
Tssr139317	Chr16:90628103-90628112 (+)	4,501 bp
Tssr139318	Chr16:90629659-90629665 (+)	6,055 bp
Tssr139319	Chr16:90643517-90643519 (+)	19,911 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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