Ccdc136 MGI Mouse Gene Detail - MGI:1918128 - coiled-coil domain containing 136

Symbol

Ccdc136
Name

coiled-coil domain containing 136
Synonyms

4921511K06Rik, MGC:8047

Feature Type

protein coding gene
IDs

MGI:1918128
NCBI Gene: 232664
Alliance

gene page
Transcription Start Sites

8 TSS

Sequence Map

Chr6:29396296-29426954 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 6, 12.36 cM
Mapping Data

2 experiments

SNPs within 2kb

671 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1918128	protein coding gene	Chr6:29396296-29426987 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0030522	protein coding gene	Chr6:27188162-27218932 (+)
A/J	MGP_AJ_G0030495	protein coding gene	Chr6:26036984-26067682 (+)
AKR/J	MGP_AKRJ_G0030422	protein coding gene	Chr6:26898367-26929122 (+)
BALB/cJ	MGP_BALBcJ_G0030505	protein coding gene	Chr6:26193182-26224356 (+)
C3H/HeJ	MGP_C3HHeJ_G0030218	protein coding gene	Chr6:26896729-26927342 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0030959	protein coding gene	Chr6:27974211-28005965 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0028170	protein coding gene	Chr6:24244396-24274773 (+)
CAST/EiJ	MGP_CASTEiJ_G0029620	protein coding gene	Chr6:26694432-26727778 (+)
CBA/J	MGP_CBAJ_G0030196	protein coding gene	Chr6:29016875-29051403 (+)
DBA/2J	MGP_DBA2J_G0030340	protein coding gene	Chr6:25979931-26015063 (+)
FVB/NJ	MGP_FVBNJ_G0030294	protein coding gene	Chr6:25737562-25768583 (+)
LP/J	MGP_LPJ_G0030427	protein coding gene	Chr6:27321482-27352147 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0030330	protein coding gene	Chr6:31533205-31565270 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0030989	protein coding gene	Chr6:26772780-26804219 (+)
PWK/PhJ	MGP_PWKPhJ_G0029334	protein coding gene	Chr6:25516563-25547612 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0029170	protein coding gene	Chr6:26490612-26523075 (+)
WSB/EiJ	MGP_WSBEiJ_G0029696	protein coding gene	Chr6:26743907-26774468 (+)

Human Ortholog

CCDC136, coiled-coil domain containing 136

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CCDC136, coiled-coil domain containing 136
Synonyms

NAG6
Links

HGNC:22225

NCBI Gene ID: 64753

UniProt: Q96JN2
Chr Location

7q32.1; chr7:128790757-128822132 (+) GRCh38

MGI Vertebrate Homology

Ccdc136 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: CCDC136
Gene Tree

Ccdc136

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Phenotype Summary

6 phenotypes from 1 allele in 1 genetic background
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Endonuclease-mediated

3
Gene trapped

4
Targeted

2
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

33 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit male infertility, globozoospermia, asthenozoospermia, and decreased in vitro fertilization frequency.

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All GO Annotations

14
GO References

5

Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

767
Tissues

13
cDNA Data

10
Literature Summary

4

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ccdc136

ZFIN ccdc136a, ccdc136b

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All Sequences

132
RefSeq

67
UniProt

10
CCDS

CCDS51736.2, CCDS59693.1, CCDS85019.1, CCDS85020.1, CCDS85021.1

Ensembl

ENSMUSG00000029769 (Evidence)
NCBI Gene

232664

			Length	Strain/Species	Flank
genomic	232664	NCBI Gene Model \| MGI Sequence Detail	30659	C57BL/6J	± kb
transcript	NM_001347071	RefSeq \| MGI Sequence Detail	3887	C57BL/6
polypeptide	Q3TVA9	UniProt \| EBI \| MGI Sequence Detail	1136	Not Applicable

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UniProt

10 Sequences
Protein Ontology

PR:000030547 coiled-coil domain-containing protein 136

(term hierarchy)
InterPro Domains

IPR051176 Centrosomal and Immune Signaling Modulators
GlyGen

Q3TVA9 1 site, 1 N-linked glycan (1 site)

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All nucleic 13

cDNA 10

Primer pair 2

Other 1

Microarray probesets 3

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MGI:2385256

Summaries

All 40

Developmental Gene Expression 4

Gene Ontology 5

Phenotypes 11
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Ccdc136:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr55250	Chr6:29397544-29397555 (+)	1,254 bp
Tssr55251	Chr6:29398919-29398930 (+)	2,629 bp
Tssr55252	Chr6:29398958-29398965 (+)	2,666 bp
Tssr55253	Chr6:29399197-29399210 (+)	2,908 bp
Tssr55254	Chr6:29402870-29402920 (+)	6,599 bp
Tssr55255	Chr6:29419198-29419205 (+)	22,906 bp
Tssr55256	Chr6:29419271-29419281 (+)	22,980 bp
Tssr55257	Chr6:29419991-29420001 (+)	23,700 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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