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Hmgxb4 Gene Detail
Summary
  • Symbol
    Hmgxb4
  • Name
    HMG box domain containing 4
  • Synonyms
    4733401K04Rik, Hmgb2l1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1918073
    NCBI Gene: 70823
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:75720305-75758606 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 8, 35.57 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    77 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1918073
protein coding gene Chr8:75719984-75758606 (+)
129S1/SvImJ MGP_129S1SvImJ_G0033793
protein coding gene Chr8:75435994-75481481 (+)
A/J MGP_AJ_G0033775
protein coding gene Chr8:72477482-72517128 (+)
AKR/J MGP_AKRJ_G0033702
protein coding gene Chr8:74683524-74725870 (+)
BALB/cJ MGP_BALBcJ_G0033769
protein coding gene Chr8:72571267-72613742 (+)
C3H/HeJ MGP_C3HHeJ_G0033478
protein coding gene Chr8:75238345-75283808 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034289
protein coding gene Chr8:78366441-78407734 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031230
protein coding gene Chr8:66746318-66787244 (+)
CAST/EiJ MGP_CASTEiJ_G0032807
protein coding gene Chr8:74522143-74560044 (+)
CBA/J MGP_CBAJ_G0033457
protein coding gene Chr8:81119745-81162328 (+)
DBA/2J MGP_DBA2J_G0033611
protein coding gene Chr8:72159306-72204651 (+)
FVB/NJ MGP_FVBNJ_G0033556
protein coding gene Chr8:71243013-71281649 (+)
LP/J MGP_LPJ_G0033700
protein coding gene Chr8:75567876-75608703 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033599
protein coding gene Chr8:83682072-83724039 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034306
protein coding gene Chr8:74652406-74691614 (+)
PWK/PhJ no annotation
SPRET/EiJ MGP_SPRETEiJ_G0032351
protein coding gene Chr8:73535215-73582175 (+)
WSB/EiJ MGP_WSBEiJ_G0032922
protein coding gene Chr8:74958678-74997837 (+)



Homology
more
  • Human Ortholog
    HMGXB4, HMG-box containing 4
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HMGXB4, HMG-box containing 4
  • Synonyms
    HMG2L1, HMGBCG, P53N, THC211630
  • Links
    NCBI Gene ID: 10042
    neXtProt AC: NX_Q9UGU5
    UniProt: Q9UGU5

  • Chr Location
    22q12.3; chr22:35241536-35295807 (+)  GRCh38

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotype references
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 70823 NCBI Gene Model | MGI Sequence Detail 38302 C57BL/6J ±  kb
transcript NM_001316753 RefSeq | MGI Sequence Detail 3991 C57BL/6  
polypeptide NP_821136 RefSeq | MGI Sequence Detail 594 C57BL/6  
For the selected sequence
Protein
Information
less
  • UniProt
    8 Sequences
  • InterPro Domains
    IPR025228 Domain of unknown function DUF4171
    IPR009071 High mobility group box domain
    IPR036910 High mobility group box domain superfamily
    IPR042477 HMG domain-containing protein 4
    IPR048016 HMG domain-containing protein 4, HMG-box
Molecular
Reagents
less
  • All nucleic 103
    Genomic 1
    cDNA 101
    Primer pair 1

    Microarray probesets 5
Other
Accession IDs
less
MGI:2142500
References
more
  • Summaries
    All 40
    Developmental Gene Expression 6
    Gene Ontology 1
    Phenotypes 10
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:302603 He X, et al., Deficiency of the novel high mobility group protein HMGXB4 protects against systemic inflammation-induced endotoxemia in mice. Proc Natl Acad Sci U S A. 2021 Feb 16;118(7):e2021862118

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory