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Arrdc2 Gene Detail
Summary
  • Symbol
    Arrdc2
  • Name
    arrestin domain containing 2
  • Synonyms
    4632416I05Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1918057
    NCBI Gene: 70807
  • Alliance
    genome feature page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:71287773-71292364 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 34.26 cM, cytoband C1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    219 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1918057
 protein coding gene Chr8:71287773-71293173 (-)
129S1/SvImJ ENSMUSG00200027166
 protein coding gene Chr8:66088795-66094125 (-)
A/J ENSMUSG00195016357
 protein coding gene Chr8:66418272-66423384 (-)
AKR/J ENSMUSG00220021073
 protein coding gene Chr8:66332694-66337801 (-)
BALB/cJ ENSMUSG00180025715
 protein coding gene Chr8:66063265-66068595 (-)
C3H/HeJ ENSMUSG00175021781
 protein coding gene Chr8:66343239-66348570 (-)
C57BL/6NJ ENSMUSG00215016860
 protein coding gene Chr8:66020752-66025864 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031169
 protein coding gene Chr8:63058558-63063106 (-)
CAST/EiJ ENSTCUG00005038402
 protein coding gene Chr8:65821962-65827070 (-)
CBA/J ENSMUSG00210029198
 protein coding gene Chr8:66108782-66114113 (-)
DBA/2J ENSMUSG00185012319
 protein coding gene Chr8:72268394-72273725 (-)
FVB/NJ ENSMUSG00205037343
 protein coding gene Chr8:65613011-65618342 (-)
JF1/MsJ ENSUMUG00000038746
 protein coding gene Chr8:74546600-74551181 (-)
LP/J ENSMUSG00230026579
 protein coding gene Chr8:75879898-75885228 (-)
NOD/ShiLtJ ENSMUSG00190023010
 protein coding gene Chr8:66027866-66032978 (-)
NZO/HlLtJ ENSMUSG00225045726
 protein coding gene Chr8:79289062-79294393 (-)
PWK/PhJ ENSLUMG00010030341
 protein coding gene Chr8:66003706-66008813 (-)
SPRET/EiJ ENSMSPG00010032730
 protein coding gene Chr8:67688407-67693479 (-)
WSB/EiJ ENSIUOG00005025845
 protein coding gene Chr8:66899811-66904918 (-)



Homology
more
  • Human Ortholog
    ARRDC2, arrestin domain containing 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ARRDC2, arrestin domain containing 2
  • Synonyms
    CLONE24945, PP2703
  • Links
    NCBI Gene ID: 27106
    UniProt: Q8TBH0

  • Chr Location
    19p13.11; chr19:18001124-18014102 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    10
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    601
  • Tissues
    4
  • cDNA Data
    32
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000002910 Ensembl Gene Model | MGI Sequence Detail 4592 C57BL/6J ±  kb
    transcript ENSMUST00000002989 Ensembl | MGI Sequence Detail 2355 Not Applicable  
    polypeptide ENSMUSP00000002989 Ensembl | MGI Sequence Detail 407 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 32
      cDNA 32

      Microarray probesets 3
    References
    more
    • Summaries
      All 39
      Developmental Gene Expression 2
      Gene Ontology 4
      Phenotypes 9
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:367408 Laskin GR, et al., The mechanosensitive gene arrestin domain containing 2 regulates myotube diameter with direct implications for disuse atrophy with aging. Am J Physiol Cell Physiol. 2024 Mar 1;326(3):C768-C783
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory