Arhgef26 MGI Mouse Gene Detail - MGI:1918053 - Rho guanine nucleotide exchange factor 26

Symbol

Arhgef26
Name

Rho guanine nucleotide exchange factor 26
Synonyms

4631416L12Rik, 8430436L14Rik

Feature Type

protein coding gene
IDs

MGI:1918053
NCBI Gene: 622434
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr3:62245765-62369642 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 3, 29.97 cM
Mapping Data

2 experiments

SNPs within 2kb

693 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1918053	protein coding gene	Chr3:62244946-62369642 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0027258	protein coding gene	Chr3:61305907-61440653 (+)
A/J	MGP_AJ_G0027218	protein coding gene	Chr3:59536686-59655818 (+)
AKR/J	MGP_AKRJ_G0027188	protein coding gene	Chr3:60686192-60806899 (+)
BALB/cJ	MGP_BALBcJ_G0027231	protein coding gene	Chr3:59276905-59398613 (+)
C3H/HeJ	MGP_C3HHeJ_G0026974	protein coding gene	Chr3:60877276-60998857 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0027677	protein coding gene	Chr3:63610405-63733369 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0025031	protein coding gene	Chr3:56061451-56171583 (+)
CAST/EiJ	MGP_CASTEiJ_G0026426	protein coding gene	Chr3:61066241-61183763 (+)
CBA/J	MGP_CBAJ_G0026950	protein coding gene	Chr3:65654085-65789389 (+)
DBA/2J	MGP_DBA2J_G0027084	protein coding gene	Chr3:58917408-59038856 (+)
FVB/NJ	MGP_FVBNJ_G0027052	protein coding gene	Chr3:57762653-57877806 (+)
LP/J	MGP_LPJ_G0027195	protein coding gene	Chr3:62169173-62302888 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0027069	protein coding gene	Chr3:70076721-70205967 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0027735	protein coding gene	Chr3:60592111-60716679 (+)
PWK/PhJ	MGP_PWKPhJ_G0026158	protein coding gene	Chr3:58541622-58658442 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0025971	protein coding gene	Chr3:60137080-60256529 (+)
WSB/EiJ	MGP_WSBEiJ_G0026500	protein coding gene	Chr3:60741892-60862504 (+)

Human Ortholog

ARHGEF26, Rho guanine nucleotide exchange factor 26

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ARHGEF26, Rho guanine nucleotide exchange factor 26
Synonyms

CSGEF, HMFN1864, SGEF
Links

HGNC:24490

NCBI Gene ID: 26084

neXtProt AC: NX_Q96DR7

UniProt: Q96DR7
Chr Location

3q25.2; chr3:154121003-154257827 (+) GRCh38

Alliance of Genome Resources

Arhgef26 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: ARHGEF26
Gene Tree

Arhgef26

less

References

1 with disease annotations

less

Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
1 phenotype from multigenic genotypes
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

11
Chemically induced (other)

1
Endonuclease-mediated

3
Gene trapped

1
Radiation induced

1
Targeted

5
Genomic Mutations

2 involving Arhgef26
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

37 strains or lines available

Mice homozygous for a knock-out allele exhibit defective activation of RhoG and reduced membrane protrusion after ICAM-1 clustering.

less

All GO Annotations

3
GO References

2

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

711
Tissues

1
cDNA Data

11
Literature Summary

2

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase arhgef26

less

Arhgef26 interacts with 265 markers (Mir1a-1, Mir1a-2, Mir1b, ...) View All

less

All Sequences

46
RefSeq

4
UniProt

2
CCDS

CCDS38443.1

Ensembl

ENSMUSG00000036885 (Evidence)
NCBI Gene

622434

			Length	Strain/Species	Flank
genomic	ENSMUSG00000036885	Ensembl Gene Model \| MGI Sequence Detail	123878	C57BL/6J	± kb
transcript	ENSMUST00000079300	Ensembl \| MGI Sequence Detail	5638	Not Applicable
polypeptide	ENSMUSP00000078281	Ensembl \| MGI Sequence Detail	869	Not Applicable

less

UniProt

2 Sequences
InterPro Domains

IPR035797 ARHGEF16/ARHGEF26, SH3 domain

IPR000219 Dbl homology (DH) domain

IPR035899 Dbl homology (DH) domain superfamily

IPR047271 Ephexin-like

IPR047270 Ephexin-like, PH domain

IPR011993 PH-like domain superfamily

IPR001849 Pleckstrin homology domain

IPR001452 SH3 domain

IPR036028 SH3-like domain superfamily

less

All nucleic 11

cDNA 11

Microarray probesets 6

less

MGI:1918810, MGI:2139660, MGI:2139988

Summaries

All 35

Developmental Gene Expression 2

Diseases 1

Gene Ontology 2

Phenotypes 12
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:331761 Zhu QM, et al., Endothelial ARHGEF26 is an angiogenic factor promoting VEGF signalling. Cardiovasc Res. 2022 Oct 21;118(13):2833-2846

TSS for Arhgef26:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr29350	Chr3:62246362-62246433 (+)	633 bp
Tssr29351	Chr3:62246445-62246458 (+)	687 bp
Tssr29352	Chr3:62246994-62247031 (+)	1,248 bp
Tssr29353	Chr3:62247467-62247479 (+)	1,708 bp
Tssr889	Chr3:62303843-62303847 (+)	58,080 bp
Tssr29354	Chr3:62343078-62343085 (+)	97,317 bp
Tssr29355	Chr3:62352294-62352298 (+)	106,531 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/19/2023 MGI 6.22