Arhgef26 MGI Mouse Gene Detail - MGI:1918053 - Rho guanine nucleotide exchange factor 26

Symbol

Arhgef26
Name

Rho guanine nucleotide exchange factor 26
Synonyms

4631416L12Rik, 8430436L14Rik

Feature Type

protein coding gene
IDs

MGI:1918053
NCBI Gene: 622434
Alliance

genome feature page
Transcription Start Sites

7 TSS

Sequence Map

Chr3:62245765-62369642 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 3, 29.97 cM
Mapping Data

2 experiments

SNPs within 2kb

3151 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1918053	protein coding gene	Chr3:62244946-62369642 (+)
129S1/SvImJ	ENSMUSG00200022778	protein coding gene	Chr3:59161206-59285099 (+)
A/J	ENSMUSG00195031633	protein coding gene	Chr3:59106890-59230825 (+)
AKR/J	ENSMUSG00220027745	protein coding gene	Chr3:57447883-57572867 (-)
BALB/cJ	ENSMUSG00180023120	protein coding gene	Chr3:59158133-59283115 (+)
C3H/HeJ	ENSMUSG00175008580	protein coding gene	Chr3:59008496-59122174 (+)
C57BL/6NJ	ENSMUSG00215008612	protein coding gene	Chr3:59440149-59564033 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0025031	protein coding gene	Chr3:56061451-56171583 (+)
CAST/EiJ	ENSTCUG00005002332	protein coding gene	Chr3:58774799-58888340 (+)
CBA/J	ENSMUSG00210003421	protein coding gene	Chr3:59118047-59231732 (+)
DBA/2J	ENSMUSG00185027470	protein coding gene	Chr3:59258589-59383054 (+)
FVB/NJ	ENSMUSG00205003093	protein coding gene	Chr3:58241485-58355161 (+)
JF1/MsJ	ENSUMUG00000002840	protein coding gene	Chr3:58981096-59095361 (+)
LP/J	ENSMUSG00230004041	protein coding gene	Chr3:61297931-61421815 (+)
NOD/ShiLtJ	ENSMUSG00190027501	protein coding gene	Chr3:59536600-59661579 (+)
NZO/HlLtJ	ENSMUSG00225002081	protein coding gene	Chr3:63900277-64024160 (+)
PWK/PhJ	ENSLUMG00010004859	protein coding gene	Chr3:58777247-58891451 (+)
SPRET/EiJ	ENSMSPG00010007474	protein coding gene	Chr3:59570142-59682878 (+)
WSB/EiJ	ENSIUOG00005007751	protein coding gene	Chr3:59264174-59378237 (+)

Human Ortholog

ARHGEF26, Rho guanine nucleotide exchange factor 26

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ARHGEF26, Rho guanine nucleotide exchange factor 26
Synonyms

CSGEF, HMFN1864, SGEF
Links

HGNC:24490

NCBI Gene ID: 26084

UniProt: Q96DR7
Chr Location

3q25.2; chr3:154121003-154257827 (+) GRCh38

MGI Vertebrate Homology

Arhgef26 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: ARHGEF26
Gene Tree

Arhgef26

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References

1 with disease annotations

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Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
1 phenotype from multigenic genotypes
15 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

12
Chemically induced (other)

1
Endonuclease-mediated

4
Gene trapped

1
Radiation induced

1
Targeted

5
Genomic Mutations

2 involving Arhgef26
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

49 strains or lines available

Mice homozygous for a knock-out allele exhibit defective activation of RhoG and reduced membrane protrusion after ICAM-1 clustering.

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All GO Annotations

9
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

602
Tissues

1
cDNA Data

11
Literature Summary

2

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase arhgef26

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All Sequences

47
RefSeq

4
UniProt

2
CCDS

CCDS38443.1

Ensembl

ENSMUSG00000036885 (Evidence)
NCBI Gene

622434

			Length	Strain/Species	Flank
genomic	ENSMUSG00000036885	Ensembl Gene Model \| MGI Sequence Detail	123878	C57BL/6J	± kb
transcript	ENSMUST00000079300	Ensembl \| MGI Sequence Detail	5638	Not Applicable
polypeptide	ENSMUSP00000078281	Ensembl \| MGI Sequence Detail	869	Not Applicable

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UniProt

2 Sequences
InterPro Domains

IPR035797 ARHGEF16/ARHGEF26, SH3 domain

IPR035899 Dbl homology (DH) domain superfamily

IPR000219 Dbl homology domain

IPR047271 Ephexin-like

IPR047270 Ephexin-like, PH domain

IPR011993 PH-like domain superfamily

IPR001849 Pleckstrin homology domain

IPR001452 SH3 domain

IPR036028 SH3-like domain superfamily

IPR055251 SOS1/NGEF-like, PH domain

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All nucleic 11

cDNA 11

Microarray probesets 6

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MGI:1918810, MGI:2139660, MGI:2139988

Summaries

All 42

Developmental Gene Expression 2

Diseases 1

Gene Ontology 6

Phenotypes 15
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Arhgef26:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr29350	Chr3:62246362-62246433 (+)	633 bp
Tssr29351	Chr3:62246445-62246458 (+)	687 bp
Tssr29352	Chr3:62246994-62247031 (+)	1,248 bp
Tssr29353	Chr3:62247467-62247479 (+)	1,708 bp
Tssr889	Chr3:62303843-62303847 (+)	58,080 bp
Tssr29354	Chr3:62343078-62343085 (+)	97,317 bp
Tssr29355	Chr3:62352294-62352298 (+)	106,531 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/01/2026 MGI 6.24