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Nos1ap Gene Detail
Summary
  • Symbol
    Nos1ap
  • Name
    nitric oxide synthase 1 (neuronal) adaptor protein
  • Synonyms
    6330408P19Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1917979
    NCBI Gene: 70729
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:170143039-170417371 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 76.84 cM, cytoband H2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    8335 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1917979
 protein coding gene Chr1:170130237-170417430 (-)
129S1/SvImJ ENSMUSG00200043301
 protein coding gene Chr1:167605990-167891450 (-)
A/J ENSMUSG00195045829
 protein coding gene Chr1:166925199-167210195 (-)
AKR/J ENSMUSG00220025683
 protein coding gene Chr1:166634524-166909350 (-)
BALB/cJ ENSMUSG00180043565
 protein coding gene Chr1:167202319-167477112 (-)
C3H/HeJ ENSMUSG00175047033
 protein coding gene Chr1:167261585-167547020 (-)
C57BL/6NJ ENSMUSG00215044526
 protein coding gene Chr1:167085792-167358442 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014841
 protein coding gene Chr1:160558169-160846482 (-)
CAST/EiJ ENSTCUG00005045347
 protein coding gene Chr1:165591996-165868178 (-)
CBA/J ENSMUSG00210038231
 protein coding gene Chr1:167167395-167442185 (-)
DBA/2J ENSMUSG00185011718
 protein coding gene Chr1:171384208-171659030 (-)
FVB/NJ ENSMUSG00205025725
 protein coding gene Chr1:166123734-166409166 (-)
JF1/MsJ ENSUMUG00000004654
 protein coding gene Chr1:170527511-170802444 (-)
LP/J no annotation
NOD/ShiLtJ ENSMUSG00190028383
 protein coding gene Chr1:166924243-167209803 (-)
NZO/HlLtJ no annotation
PWK/PhJ ENSLUMG00010027426
 protein coding gene Chr1:165918429-166199220 (-)
SPRET/EiJ ENSMSPG00010045037
 protein coding gene Chr1:169471712-169750790 (-)
WSB/EiJ ENSIUOG00005035236
 protein coding gene Chr1:166333037-166611862 (-)



Homology
more
  • Human Ortholog
    NOS1AP, nitric oxide synthase 1 adaptor protein
  • Vertebrate Orthologs
    5
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NOS1AP, nitric oxide synthase 1 adaptor protein
  • Synonyms
    6330408P19Rik, CAPON, NPHS22
  • Links
    NCBI Gene ID: 9722
    UniProt: O75052

  • Chr Location
    1q23.3; chr1:162069691-162370475 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human NOS1AP associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    22 phenotypes from 2 alleles in 2 genetic backgrounds
    1 phenotype from multigenic genotypes
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit oxidative stress induced ventricular arrhythmia and increased induced mortality associated with impairment cardiac function.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    29
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    621
  • Tissues
    21
  • cDNA Data
    6
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 70729 NCBI Gene Model | MGI Sequence Detail 274333 C57BL/6J ±  kb
    transcript NR_154593 RefSeq | MGI Sequence Detail 8423 C57BL/6  
    polypeptide Q9D3A8 UniProt | EBI | MGI Sequence Detail 503 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 8
      cDNA 8

      Microarray probesets 3
    References
    more
    • Summaries
      All 53
      Developmental Gene Expression 4
      Gene Ontology 8
      Phenotypes 16
    • Earliest
      J:77278 Fang M, et al., Dexras1: a G protein specifically coupled to neuronal nitric oxide synthase via CAPON. Neuron. 2000 Oct;28(1):183-93
    • Latest
      J:375772 Buerger F, et al., Recessive variants in the intergenic NOS1AP-C1orf226 locus cause monogenic kidney disease responsive to anti-proteinuric treatment. Nat Commun. 2025 Nov 27;16(1):10654
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory