Arhgap45 MGI Mouse Gene Detail - MGI:1917969 - Rho GTPase activating protein 45

Symbol

Arhgap45
Name

Rho GTPase activating protein 45
Synonyms

6330406L22Rik, Hmha1

Feature Type

protein coding gene
IDs

MGI:1917969
NCBI Gene: 70719
Alliance

gene page
Transcription Start Sites

15 TSS

Sequence Map

Chr10:79852505-79867305 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 39.72 cM
Mapping Data

3 experiments

SNPs within 2kb

371 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1917969	protein coding gene	Chr10:79852487-79867306 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0017478	protein coding gene	Chr10:80589570-80606660 (+)
A/J	MGP_AJ_G0017456	protein coding gene	Chr10:77773730-77789006 (+)
AKR/J	MGP_AKRJ_G0017417	protein coding gene	Chr10:79891687-79910079 (+)
BALB/cJ	MGP_BALBcJ_G0017418	protein coding gene	Chr10:78000234-78015713 (+)
C3H/HeJ	MGP_C3HHeJ_G0017241	protein coding gene	Chr10:79997462-80014477 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0017872	protein coding gene	Chr10:83373721-83389928 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015560	protein coding gene	Chr10:73998474-74013982 (+)
CAST/EiJ	MGP_CASTEiJ_G0016808	protein coding gene	Chr10:80195940-80211939 (+)
CBA/J	MGP_CBAJ_G0017213	protein coding gene	Chr10:86600492-86618922 (+)
DBA/2J	MGP_DBA2J_G0017319	protein coding gene	Chr10:76989531-77004171 (+)
FVB/NJ	MGP_FVBNJ_G0017313	protein coding gene	Chr10:76168773-76183740 (+)
LP/J	MGP_LPJ_G0017390	protein coding gene	Chr10:81066834-81083207 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017339	protein coding gene	Chr10:88561853-88577285 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0017913	protein coding gene	Chr10:79879646-79894231 (+)
PWK/PhJ	MGP_PWKPhJ_G0016589	protein coding gene	Chr10:76856175-76871342 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0016378	protein coding gene	Chr10:78852946-78869236 (+)
WSB/EiJ	MGP_WSBEiJ_G0016868	protein coding gene	Chr10:79905161-79922075 (+)

Human Ortholog

ARHGAP45, Rho GTPase activating protein 45

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ARHGAP45, Rho GTPase activating protein 45
Synonyms

HA-1, HLA-HA1, HMHA1
Links

HGNC:17102

NCBI Gene ID: 23526

neXtProt AC: NX_Q92619

UniProt: Q92619
Chr Location

19p13.3; chr19:1065923-1086628 (+) GRCh38

MGI Vertebrate Homology

Arhgap45 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: ARHGAP45
Gene Tree

Arhgap45

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Phenotype Summary

12 phenotypes from 1 allele in 1 genetic background
13 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

2
Targeted

4
Genomic Mutations

1 involving Arhgap45
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

60 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous knockout affects naive T and B cell chemotaxis and their entry into lymph nodes and leads to reduced numbers of certain T and B cell sub-populations in blood, LNs and thymus.

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All GO Annotations

9
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

56

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase arhgap45

ZFIN arhgap45b

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All Sequences

64
RefSeq

13
UniProt

3
CCDS

CCDS24005.1, CCDS48624.1, CCDS83725.1

Ensembl

ENSMUSG00000035697 (Evidence)
NCBI Gene

70719

			Length	Strain/Species	Flank
genomic	70719	NCBI Gene Model \| MGI Sequence Detail	14801	C57BL/6J	± kb
transcript	NM_001142701	RefSeq \| MGI Sequence Detail	3928	C57BL/6
polypeptide	Q3TBD2	UniProt \| EBI \| MGI Sequence Detail	1116	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000008642 Rho GTPase-activating protein 45

(term hierarchy)
InterPro Domains

IPR027267 AH/BAR domain superfamily

IPR046349 C1-like domain superfamily

IPR031160 F-BAR domain

IPR001060 FCH domain

IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol-binding domain

IPR051025 Rho GTPase-activating

IPR000198 Rho GTPase-activating protein domain

IPR008936 Rho GTPase activation protein
GlyGen

Q3TBD2 1 site, 1 O-linked glycan (1 site)

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All nucleic 57

Genomic 1

cDNA 56

Microarray probesets 3

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MGI:2143851

Summaries

All 37

Gene Ontology 5

Phenotypes 13
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:309971 He L, et al., ARHGAP45 controls naive T- and B-cell entry into lymph nodes and T-cell progenitor thymus seeding. EMBO Rep. 2021 Apr 7;22(4):e52196

TSS for Arhgap45:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr94455	Chr10:79851623-79851672 (+)	-857 bp
Tssr94456	Chr10:79852496-79852511 (+)	-1 bp
Tssr94457	Chr10:79852530-79852567 (+)	44 bp
Tssr94458	Chr10:79852569-79852592 (+)	76 bp
Tssr94459	Chr10:79852595-79852602 (+)	94 bp
Tssr94460	Chr10:79852735-79852739 (+)	232 bp
Tssr94461	Chr10:79852803-79852812 (+)	303 bp
Tssr94462	Chr10:79853435-79853473 (+)	949 bp
Tssr94463	Chr10:79853501-79853521 (+)	1,006 bp
Tssr94464	Chr10:79853526-79853543 (+)	1,030 bp
Tssr94465	Chr10:79853694-79853739 (+)	1,212 bp
Tssr94466	Chr10:79853776-79853787 (+)	1,277 bp
Tssr94467	Chr10:79853933-79853945 (+)	1,434 bp
Tssr94468	Chr10:79855190-79855193 (+)	2,687 bp
Tssr94469	Chr10:79855455-79855524 (+)	2,985 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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