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Abraxas1 Gene Detail
Summary
  • Symbol
    Abraxas1
  • Name
    BRCA1 A complex subunit
  • Synonyms
    3830405G04Rik, 5630400M01Rik, Ccdc98, Fam175a
  • Feature Type
    protein coding gene
  • IDs
    MGI:1917931
    NCBI Gene: 70681
  • Alliance
    genome feature page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:100953058-100968831 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 48.52 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    482 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1917931
 protein coding gene Chr5:100952668-100968831 (-)
129S1/SvImJ ENSMUSG00200005372
 protein coding gene Chr5:94700893-94716655 (-)
A/J ENSMUSG00195033837
 protein coding gene Chr5:94261566-94277331 (-)
AKR/J ENSMUSG00220036156
 protein coding gene Chr5:93731608-93747373 (-)
BALB/cJ ENSMUSG00180034305
 protein coding gene Chr5:94417782-94433548 (-)
C3H/HeJ ENSMUSG00175030665
 protein coding gene Chr5:96522411-96538170 (-)
C57BL/6NJ ENSMUSG00215009342
 protein coding gene Chr5:94338470-94354244 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027459
 protein coding gene Chr5:93744920-93761023 (-)
CAST/EiJ ENSTCUG00005023547
 protein coding gene Chr5:93726334-93742119 (-)
CBA/J ENSMUSG00210032738
 protein coding gene Chr5:95272748-95288511 (-)
DBA/2J ENSMUSG00185034081
 protein coding gene Chr5:98191098-98206861 (-)
FVB/NJ ENSMUSG00205029298
 protein coding gene Chr5:94167893-94183659 (-)
JF1/MsJ ENSUMUG00000039360
 protein coding gene Chr5:101150911-101166815 (-)
LP/J ENSMUSG00230023755
 protein coding gene Chr5:102242518-102258279 (-)
NOD/ShiLtJ ENSMUSG00190022796
 protein coding gene Chr5:94168962-94184731 (-)
NZO/HlLtJ ENSMUSG00225012462
 protein coding gene Chr5:110006799-110022563 (-)
PWK/PhJ ENSLUMG00010013025
 protein coding gene Chr5:93273719-93289607 (-)
SPRET/EiJ ENSMSPG00010023386
 protein coding gene Chr5:96163770-96179632 (-)
WSB/EiJ ENSIUOG00005028527
 protein coding gene Chr5:96898155-96913909 (-)



Homology
more
  • Human Ortholog
    ABRAXAS1, abraxas 1, BRCA1 A complex subunit
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ABRAXAS1, abraxas 1, BRCA1 A complex subunit
  • Synonyms
    ABRA1, CCDC98, FAM175A
  • Links
    NCBI Gene ID: 84142
    UniProt: Q6UWZ7

  • Chr Location
    4q21.23; chr4:83459517-83523348 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from 1 allele in 1 genetic background
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit increased tumor incidence, genetic instability and premature lethality. Mice heterozygous for a knock-out allele exhibit increased tumor incidence and premature death.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    33
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    597
  • cDNA Data
    12
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000035234 Ensembl Gene Model | MGI Sequence Detail 15774 C57BL/6J ±  kb
    transcript ENSMUST00000200657 Ensembl | MGI Sequence Detail 1668 Not Applicable  
    polypeptide ENSMUSP00000143465 Ensembl | MGI Sequence Detail 407 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 13
      cDNA 13

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1918690, MGI:2140928, MGI:2141021, MGI:2141115, MGI:5896594
    References
    more
    • Summaries
      All 42
      Gene Ontology 7
      Phenotypes 13
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:269823 Castillo A, et al., The BRCA1-interacting protein Abraxas is required for genomic stability and tumor suppression. Cell Rep. 2014 Aug 7;8(3):807-17
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory