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Ecd Gene Detail
Summary
  • Symbol
    Ecd
  • Name
    ecdysoneless cell cycle regulator
  • Synonyms
    5730461K03Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1917851
    NCBI Gene: 70601
  • Alliance
    genome feature page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:20369927-20398189 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 11.51 cM, cytoband B
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    737 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1917851
 protein coding gene Chr14:20369920-20398189 (-)
129S1/SvImJ ENSMUSG00200013995
 protein coding gene Chr14:12148376-12176658 (-)
A/J ENSMUSG00195018763
 protein coding gene Chr14:13242462-13270734 (-)
AKR/J ENSMUSG00220025127
 protein coding gene Chr14:12372976-12401250 (-)
BALB/cJ ENSMUSG00180037816
 protein coding gene Chr14:12337378-12365648 (-)
C3H/HeJ ENSMUSG00175022804
 protein coding gene Chr14:12398383-12426653 (-)
C57BL/6NJ ENSMUSG00215024570
 protein coding gene Chr14:12587976-12616248 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018984
 protein coding gene Chr14:13079571-13107936 (-)
CAST/EiJ ENSTCUG00005029663
 protein coding gene Chr14:12515705-12543742 (-)
CBA/J ENSMUSG00210025799
 protein coding gene Chr14:12621486-12649763 (-)
DBA/2J ENSMUSG00185036470
 protein coding gene Chr14:16906564-16934841 (-)
FVB/NJ ENSMUSG00205024243
 protein coding gene Chr14:12462089-12490373 (-)
JF1/MsJ ENSUMUG00000041108
 protein coding gene Chr14:24122536-24150433 (-)
LP/J ENSMUSG00230036701
 protein coding gene Chr14:24188360-24216637 (-)
NOD/ShiLtJ ENSMUSG00190034915
 protein coding gene Chr14:12620418-12648696 (-)
NZO/HlLtJ ENSMUSG00225035222
 protein coding gene Chr14:18423916-18452182 (-)
PWK/PhJ ENSLUMG00010019428
 protein coding gene Chr14:694899-730034 (-)
SPRET/EiJ ENSMSPG00010028137
 protein coding gene Chr14:14250186-14278933 (-)
WSB/EiJ ENSIUOG00005030770
 protein coding gene Chr14:12445007-12473293 (-)



Homology
more
  • Human Ortholog
    ECD, ecdysoneless cell cycle regulator
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ECD, ecdysoneless cell cycle regulator
  • Synonyms
    GCR2, HSGT1, SGT1
  • Links
    NCBI Gene ID: 11319
    UniProt: O95905

  • Chr Location
    10q22.2; chr10:73130155-73169055 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit lethality (no time point given).
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    19
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    627
  • Tissues
    21
  • cDNA Data
    127
  • Literature Summary
    2
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 70601 NCBI Gene Model | MGI Sequence Detail 28263 C57BL/6J ±  kb
transcript NM_027475 RefSeq | MGI Sequence Detail 3125 C57BL/6  
polypeptide Q9CS74 UniProt | EBI | MGI Sequence Detail 641 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 129
    cDNA 129

    Microarray probesets 4
References
more
  • Summaries
    All 37
    Developmental Gene Expression 2
    Gene Ontology 6
    Phenotypes 9
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:374320 Cao X, et al., Transcriptional regulation of Rankl by Txnip-Ecd in aging and diabetic related osteoporosis. J Adv Res. 2025 Nov;77:221-234
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory