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Draxin Gene Detail
Summary
  • Symbol
    Draxin
  • Name
    dorsal inhibitory axon guidance protein
  • Synonyms
    2610109H07Rik, Neucrin
  • Feature Type
    protein coding gene
  • IDs
    MGI:1917683
    NCBI Gene: 70433
  • Alliance
    genome feature page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:148182894-148215155 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 78.67 cM, cytoband E1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    717 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1917683
 protein coding gene Chr4:148182894-148215582 (-)
129S1/SvImJ ENSMUSG00200045070
 protein coding gene Chr4:139219027-139251257 (-)
A/J ENSMUSG00195029983
 protein coding gene Chr4:140876648-140908917 (-)
AKR/J ENSMUSG00220046373
 protein coding gene Chr4:140453710-140489561 (-)
BALB/cJ ENSMUSG00180042143
 protein coding gene Chr4:138559321-138591589 (-)
C3H/HeJ ENSMUSG00175036071
 protein coding gene Chr4:141834225-141870069 (-)
C57BL/6NJ ENSMUSG00215046861
 protein coding gene Chr4:140682943-140715209 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026793
 protein coding gene Chr4:137938256-137971583 (-)
CAST/EiJ ENSTCUG00005026182
 protein coding gene Chr4:144509026-144544166 (-)
CBA/J ENSMUSG00210025868
 protein coding gene Chr4:140485911-140521756 (-)
DBA/2J ENSMUSG00185016405
 protein coding gene Chr4:144047693-144079910 (-)
FVB/NJ ENSMUSG00205022232
 protein coding gene Chr4:138952506-138984776 (-)
JF1/MsJ ENSUMUG00000003879
 protein coding gene Chr4:147075405-147108076 (-)
LP/J ENSMUSG00230014480
 protein coding gene Chr4:150792687-150822828 (-)
NOD/ShiLtJ ENSMUSG00190020928
 protein coding gene Chr4:140155859-140188402 (-)
NZO/HlLtJ ENSMUSG00225024378
 protein coding gene Chr4:154785415-154815511 (-)
PWK/PhJ ENSLUMG00010040888
 protein coding gene Chr4:139345558-139378101 (-)
SPRET/EiJ ENSMSPG00010027308
 protein coding gene Chr4:141289636-141317743 (-)
WSB/EiJ ENSIUOG00005043267
 protein coding gene Chr4:138326195-138358805 (-)



Homology
more
  • Human Ortholog
    DRAXIN, dorsal inhibitory axon guidance protein
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DRAXIN, dorsal inhibitory axon guidance protein
  • Synonyms
    AGPA3119, C1orf187, neucrin, UNQ3119
  • Links
    NCBI Gene ID: 374946
    UniProt: Q8NBI3

  • Chr Location
    1p36.22; chr1:11686635-11725857 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 2 alleles in 2 genetic backgrounds
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice show defasciculation of spinal cord commissural axons and absence of all forebrain commissures. Male homozygous mutant mice exhibited a decreased mean serum insulin level.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    30
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    880
  • Tissues
    68
  • cDNA Data
    36
  • Literature Summary
    19
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000029005 Ensembl Gene Model | MGI Sequence Detail 32262 C57BL/6J ±  kb
    transcript ENSMUST00000030862 Ensembl | MGI Sequence Detail 5200 Not Applicable  
    polypeptide ENSMUSP00000030862 Ensembl | MGI Sequence Detail 343 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 42
      cDNA 37
      Primer pair 2
      Other 3
      Antibodies 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 58
      Developmental Gene Expression 19
      Gene Ontology 11
      Phenotypes 20
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:367907 Nguyen LD, et al., Impact of ATF6 deletion on the embryonic brain development. iScience. 2025 Jun 20;28(6):112569
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory