St13 MGI Mouse Gene Detail - MGI:1917606 - suppression of tumorigenicity 13

Symbol

St13
Name

suppression of tumorigenicity 13
Synonyms

1110007I03Rik, 3110002K08Rik, Hsp70 interacting protein, HSPABP1, p48, PRO0786, SNC6

Feature Type

protein coding gene
IDs

MGI:1917606
NCBI Gene: 70356
Alliance

gene page
Transcription Start Sites

12 TSS

Sequence Map

Chr15:81247869-81283951 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 15, 38.07 cM, cytoband E2
Mapping Data

3 experiments

SNPs within 2kb

126 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1917606	protein coding gene	Chr15:81247869-81284278 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0022110	protein coding gene	Chr15:81785597-81821945 (-)
A/J	MGP_AJ_G0022071	protein coding gene	Chr15:78911422-78948006 (-)
AKR/J	MGP_AKRJ_G0022046	protein coding gene	Chr15:81107764-81144231 (-)
BALB/cJ	MGP_BALBcJ_G0022077	protein coding gene	Chr15:78940441-78976798 (-)
C3H/HeJ	MGP_C3HHeJ_G0021848	protein coding gene	Chr15:81101558-81138550 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0022520	protein coding gene	Chr15:84978474-85016271 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020050	protein coding gene	Chr15:75379644-75418794 (-)
CAST/EiJ	MGP_CASTEiJ_G0021369	protein coding gene	Chr15:81856133-81895531 (-)
CBA/J	MGP_CBAJ_G0021813	protein coding gene	Chr15:87634866-87671173 (-)
DBA/2J	MGP_DBA2J_G0021942	protein coding gene	Chr15:78394163-78430633 (-)
FVB/NJ	MGP_FVBNJ_G0021920	protein coding gene	Chr15:77434021-77470953 (-)
LP/J	MGP_LPJ_G0022010	protein coding gene	Chr15:81943878-81980438 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021940	protein coding gene	Chr15:92611478-92648871 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022534	protein coding gene	Chr15:81169705-81208887 (-)
PWK/PhJ	MGP_PWKPhJ_G0021111	protein coding gene	Chr15:78421633-78458847 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0020948	protein coding gene	Chr15:80968831-81004712 (-)
WSB/EiJ	MGP_WSBEiJ_G0021421	protein coding gene	Chr15:81597458-81635007 (-)

Human Ortholog

ST13, ST13 Hsp70 interacting protein

Vertebrate Orthologs

5

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ST13, ST13 Hsp70 interacting protein
Synonyms

AAG2, FAM10A1, FAM10A4, HIP, HOP, HSPABP, HSPABP1, P48, PRO0786, SNC6
Links

HGNC:11343

NCBI Gene ID: 6767

neXtProt AC: NX_P50502

UniProt: P50502
Chr Location

22q13.2; chr22:40824535-40857008 (-) GRCh38.p7

Human Ortholog

ST13P4, ST13, Hsp70 interacting protein pseudogene 4
Synonyms

FAM10A4, FAM10A4P
Links

HGNC:18487

NCBI Gene ID: 145165

UniProt: Q8IZP2
Chr Location

13q14.2; chr13:50172018-50173616 (+) GRCh38.p7

Human Ortholog

ST13P5, ST13, Hsp70 interacting protein pseudogene 5
Synonyms

FAM10A5
Links

HGNC:18556

NCBI Gene ID: 144106

UniProt: Q8NFI4
Chr Location

11p15.1; chr11:18261885-18263501 (+) GRCh38.p7

Alliance of Genome Resources

St13 stringent orthology
3 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: ST13, ST13P4, ST13P5
Gene Tree

St13

less

References

1 with disease annotations

less

Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
29 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

57
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

52
Radiation induced

2
Targeted

1
Genomic Mutations

3 involving St13
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

26 strains or lines available

less

All GO Annotations

17
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

236
Literature Summary

1

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase st13

ZFIN st13

less

St13 interacts with 218 markers (Mir1a-1, Mir1a-2, Mir7-1, ...) View All

less

All Sequences

70
RefSeq

4
UniProt

9
CCDS

CCDS27667.1

Ensembl

ENSMUSG00000022403 (Evidence)
NCBI Gene

70356

			Length	Strain/Species	Flank
genomic	70356	NCBI Gene Model \| MGI Sequence Detail	36083	C57BL/6J	± kb
transcript	NM_133726	RefSeq \| MGI Sequence Detail	1622	C57BL/6
polypeptide	Q99L47	UniProt \| EBI \| MGI Sequence Detail	371	Not Applicable

less

UniProt

9 Sequences
Protein Ontology

PR:000015677 Hsc70-interacting protein

(term hierarchy)
InterPro Domains

IPR006636 Heat shock chaperonin-binding

IPR034649 Hsp70-interacting protein, N-terminal

IPR041243 STI1/HOP, DP domain

IPR011990 Tetratricopeptide-like helical domain superfamily

IPR019734 Tetratricopeptide repeat

less

All nucleic 236

cDNA 236

Microarray probesets 5

less

MGI:1915742, MGI:2146239

Summaries

All 58

Developmental Gene Expression 1

Diseases 1

Gene Ontology 6

Phenotypes 29
Earliest

J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
Latest

J:285676 Suzuki A, et al., Genes and microRNAs associated with mouse cleft palate: A systematic review and bioinformatics analysis. Mech Dev. 2018 Apr;150:21-27

TSS for St13:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr135476	Chr15:81284254-81284294 (-)	-323 bp
Tssr135475	Chr15:81283996-81284033 (-)	-64 bp
Tssr135474	Chr15:81283981-81283992 (-)	-36 bp
Tssr135473	Chr15:81283951-81283960 (-)	-5 bp
Tssr135472	Chr15:81283857-81283933 (-)	56 bp
Tssr135471	Chr15:81283797-81283853 (-)	126 bp
Tssr135470	Chr15:81282497-81282500 (-)	1,452 bp
Tssr135469	Chr15:81276512-81276517 (-)	7,436 bp
Tssr135468	Chr15:81264932-81264943 (-)	19,013 bp
Tssr135467	Chr15:81259074-81259097 (-)	24,865 bp
Tssr135466	Chr15:81249534-81249563 (-)	34,402 bp
Tssr135465	Chr15:81249012-81249016 (-)	34,937 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Copyright, and Privacy Statement Send questions and comments to User Support.	last database update 03/21/2023 MGI 6.22