Plscr3 MGI Mouse Gene Detail - MGI:1917560

Symbol

Plscr3
Name

phospholipid scramblase 3
Synonyms

2210403O21Rik, 2610037N06Rik

Feature Type

protein coding gene
IDs

MGI:1917560
NCBI Gene: 70310
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr11:69737202-69742884 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 42.90 cM
Mapping Data

2 experiments

SNPs within 2kb

87 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1917560	protein coding gene	Chr11:69734937-69742884 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0018561	protein coding gene	Chr11:70329414-70335096 (+)
A/J	MGP_AJ_G0018529	protein coding gene	Chr11:67666822-67672504 (+)
AKR/J	MGP_AKRJ_G0018498	protein coding gene	Chr11:69688038-69693720 (+)
BALB/cJ	MGP_BALBcJ_G0018501	protein coding gene	Chr11:67994959-68000641 (+)
C3H/HeJ	MGP_C3HHeJ_G0018314	protein coding gene	Chr11:69721573-69727255 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0018952	protein coding gene	Chr11:72454531-72460213 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016597	protein coding gene	Chr11:64590162-64596033 (+)
CAST/EiJ	MGP_CASTEiJ_G0017869	protein coding gene	Chr11:69963051-69966903 (+)
CBA/J	MGP_CBAJ_G0018287	protein coding gene	Chr11:75692173-75697855 (+)
DBA/2J	MGP_DBA2J_G0018396	protein coding gene	Chr11:67250672-67256354 (+)
FVB/NJ	MGP_FVBNJ_G0018386	protein coding gene	Chr11:66890673-66896355 (+)
LP/J	MGP_LPJ_G0018466	protein coding gene	Chr11:70896056-70901738 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018409	protein coding gene	Chr11:76300906-76306588 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0018994	protein coding gene	Chr11:69949325-69955007 (+)
PWK/PhJ	MGP_PWKPhJ_G0017643	protein coding gene	Chr11:67900751-67906555 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0017433	protein coding gene	Chr11:69767163-69772845 (+)
WSB/EiJ	MGP_WSBEiJ_G0017923	protein coding gene	Chr11:69617006-69622689 (+)

Human Ortholog

PLSCR3, phospholipid scramblase 3

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PLSCR3, phospholipid scramblase 3
Links

HGNC:16495

NCBI Gene ID: 57048

neXtProt AC: NX_Q9NRY6

UniProt: Q9NRY6
Chr Location

17p13.1; chr17:7389727-7394842 (-) GRCh38

MGI Vertebrate Homology

Plscr3 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: PLSCR3
Gene Tree

Plscr3

Diseases

1 with Plscr3 mouse models

Human Disease

Mouse Models

obesity

IDs

View 1 model

Click on a disease name to see all genes associated with that disease.

Mutations/Alleles

1 with disease annotations

References

1 with disease annotations

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Phenotype Summary

13 phenotypes from 1 allele in 1 genetic background
3 phenotypes from multigenic genotypes
19 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

1
Targeted

7
Genomic Mutations

2 involving Plscr3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

20 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous null mice display lipid-engorged adipocytes, increased abdominal fat stores, mild hyperglycemia, dyslipidemia, impaired glucose tolerance, insulin resistance, altered plasma adiponectin and leptin levels, and impaired insulin-stimulated glucose uptake by adipocytes.

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All GO Annotations

37
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

712
Tissues

4
cDNA Data

8
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase plscr3

ZFIN plscr3b

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All Sequences

52
RefSeq

10
UniProt

4
CCDS

CCDS24916.1

Ensembl

ENSMUSG00000019461 (Evidence)
NCBI Gene

70310

			Length	Strain/Species	Flank
genomic	ENSMUSG00000019461	Ensembl Gene Model \| MGI Sequence Detail	5683	C57BL/6J	± kb
transcript	ENSMUST00000108632	Ensembl \| MGI Sequence Detail	1835	Not Applicable
polypeptide	ENSMUSP00000104272	Ensembl \| MGI Sequence Detail	296	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000012886 phospholipid scramblase 3

(term hierarchy)
InterPro Domains

IPR005552 Scramblase

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All nucleic 8

cDNA 8

Microarray probesets 3

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MGD-MRK-28121, MGI:104827, MGI:1917313

Summaries

All 47

Developmental Gene Expression 1

Diseases 1

Gene Ontology 9

Phenotypes 19
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:228563 Koscielny G, et al., The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Nucleic Acids Res. 2014 Jan;42(Database issue):D802-9

TSS for Plscr3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr102536	Chr11:69737200-69737213 (+)	5 bp
Tssr102537	Chr11:69737436-69737485 (+)	259 bp
Tssr102538	Chr11:69737491-69737507 (+)	297 bp
Tssr102539	Chr11:69737676-69737773 (+)	523 bp
Tssr102540	Chr11:69738159-69738206 (+)	981 bp
Tssr102541	Chr11:69738293-69738315 (+)	1,102 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23