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Ogfrl1 Gene Detail
Summary
  • Symbol
    Ogfrl1
  • Name
    opioid growth factor receptor-like 1
  • Synonyms
    2210417C17Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1917405
    NCBI Gene: 70155
  • Alliance
    genome feature page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:23405505-23422282 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 9.57 cM, cytoband A5
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    602 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1917405
 protein coding gene Chr1:23405505-23436853 (-)
129S1/SvImJ ENSMUSG00200000593
 protein coding gene Chr1:20831796-20862886 (-)
A/J ENSMUSG00195000039
 protein coding gene Chr1:20578747-20609875 (-)
AKR/J ENSMUSG00220000555
 protein coding gene Chr1:20621417-20652469 (-)
BALB/cJ ENSMUSG00180001041
 protein coding gene Chr1:20671624-20702745 (-)
C3H/HeJ ENSMUSG00175000673
 protein coding gene Chr1:20569819-20600939 (-)
C57BL/6NJ ENSMUSG00215001043
 protein coding gene Chr1:20664135-20695258 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0013994
 protein coding gene Chr1:18882201-18909689 (-)
CAST/EiJ ENSTCUG00005000372
 protein coding gene Chr1:20882038-20916241 (-)
CBA/J ENSMUSG00210010433
 protein coding gene Chr1:20446174-20477298 (-)
DBA/2J ENSMUSG00185016377
 protein coding gene Chr1:21490419-21521539 (-)
FVB/NJ ENSMUSG00205006801
 protein coding gene Chr1:20573598-20604720 (-)
JF1/MsJ ENSUMUG00000000219
 protein coding gene Chr1:20772982-20804562 (-)
LP/J ENSMUSG00230000201
 protein coding gene Chr1:21505353-21536440 (-)
NOD/ShiLtJ ENSMUSG00190000065
 protein coding gene Chr1:20576746-20607866 (-)
NZO/HlLtJ ENSMUSG00225000320
 protein coding gene Chr1:24796732-24827852 (-)
PWK/PhJ ENSLUMG00010000118
 protein coding gene Chr1:20355804-20387396 (-)
SPRET/EiJ ENSMSPG00010000639
 protein coding gene Chr1:21342967-21356450 (-)
WSB/EiJ ENSIUOG00005001795
 protein coding gene Chr1:20555107-20586214 (-)



Homology
more
  • Human Ortholog
    OGFRL1, opioid growth factor receptor like 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    OGFRL1, opioid growth factor receptor like 1
  • Synonyms
    dJ331H24.1
  • Links
    NCBI Gene ID: 79627
    UniProt: Q5TC84

  • Chr Location
    6q13; chr6:71288811-71309059 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 3 alleles in 3 genetic backgrounds
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null mutation are viable and fertile with no facial abnormalities.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    3
  • GO References
    1
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

No experimental evidence to support Biological Process annotation, following literature review. See J:73796.
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    696
  • Tissues
    46
  • cDNA Data
    143
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 70155 NCBI Gene Model | MGI Sequence Detail 16778 C57BL/6J ±  kb
    transcript NM_001379082 RefSeq | MGI Sequence Detail 4861 C57BL/6  
    polypeptide Q8VE52 UniProt | EBI | MGI Sequence Detail 464 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • Protein Ontology
      PR:000011615 opioid growth factor receptor-like protein 1
      (term hierarchy)
    • InterPro Domains
      IPR039574 Opioid growth factor receptor
      IPR006757 Opioid growth factor receptor (OGFr)-like, conserved domain
    • GlyGen
      Q8VE52 2 sites, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 144
      cDNA 143
      Primer pair 1

      Microarray probesets 9
    References
    more
    • Summaries
      All 35
      Developmental Gene Expression 4
      Gene Ontology 1
      Phenotypes 8
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:361287 Kittaka M, et al., Loss-of-function OGFRL1 variants identified in autosomal recessive cherubism families. JBMR Plus. 2024 Jun;8(6):ziae050
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory