Spata3 MGI Mouse Gene Detail - MGI:1917310 - spermatogenesis associated 3

Symbol

Spata3
Name

spermatogenesis associated 3
Synonyms

1700011N12Rik, 1700029H01Rik, 4930424D10Rik, TSARG1

Feature Type

protein coding gene
IDs

MGI:1917310
NCBI Gene: 70060
Alliance

genome feature page
Transcription Start Sites

7 TSS

Sequence Map

Chr1:85945728-85957683 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 43.94 cM, cytoband C5
Mapping Data

2 experiments

SNPs within 2kb

326 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1917310	protein coding gene	Chr1:85944538-85957683 (+)
129S1/SvImJ	ENSMUSG00200037074	protein coding gene	Chr1:83163094-83174987 (+)
A/J	ENSMUSG00195030569	protein coding gene	Chr1:82735344-82747239 (+)
AKR/J	ENSMUSG00220038627	protein coding gene	Chr1:82856993-82868887 (+)
BALB/cJ	ENSMUSG00180015259	protein coding gene	Chr1:83032999-83044893 (+)
C3H/HeJ	ENSMUSG00175001122	protein coding gene	Chr1:82914216-82926109 (+)
C57BL/6NJ	ENSMUSG00215013893	protein coding gene	Chr1:82834743-82846633 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014355	protein coding gene	Chr1:78509312-78522341 (+)
CAST/EiJ	ENSTCUG00005007120	protein coding gene	Chr1:82483977-82495884 (+)
CBA/J	ENSMUSG00210012335	protein coding gene	Chr1:82757303-82769193 (+)
DBA/2J	ENSMUSG00185015775	protein coding gene	Chr1:87230291-87242175 (+)
FVB/NJ	ENSMUSG00205026690	protein coding gene	Chr1:82169950-82181843 (+)
JF1/MsJ	ENSUMUG00000007341	protein coding gene	Chr1:86005970-86017866 (+)
LP/J	ENSMUSG00230017390	protein coding gene	Chr1:86509035-86520928 (+)
NOD/ShiLtJ	ENSMUSG00190021046	protein coding gene	Chr1:82812414-82824307 (+)
NZO/HlLtJ	ENSMUSG00225002194	protein coding gene	Chr1:90411851-90423744 (+)
PWK/PhJ	ENSLUMG00010034809	protein coding gene	Chr1:82381203-82393084 (+)
SPRET/EiJ	ENSMSPG00010040075	protein coding gene	Chr1:84388207-84396704 (+)
WSB/EiJ	ENSIUOG00005036767	protein coding gene	Chr1:82413893-82425788 (+)

Human Ortholog

SPATA3, spermatogenesis associated 3

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SPATA3, spermatogenesis associated 3
Synonyms

TSARG1
Links

HGNC:17884

NCBI Gene ID: 130560

UniProt: Q8NHX4
Chr Location

2q37.1; chr2:230990324-231025055 (+) GRCh38

MGI Vertebrate Homology

Spata3 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: SPATA3
Gene Tree

Spata3

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Phenotype Summary

5 phenotypes from 2 alleles in 2 genetic backgrounds
10 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Chemically induced (other)

1
Endonuclease-mediated

4
Radiation induced

1
Genomic Mutations

2 involving Spata3
Incidental Mutations

APF , CvDC
Find Mice (IMSR)

15 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele exhibit normal fertility in vivo, but reduced male fertilization rates in vitro.

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All GO Annotations

4
GO References

4

Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.

Biological Process

No experimental evidence to support Biological Process annotation, following literature review. See J:73796.

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

597
cDNA Data

25

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

87
RefSeq

26
UniProt

8
CCDS

CCDS15116.1, CCDS35643.1, CCDS48301.1

Ensembl

ENSMUSG00000026226 (Evidence)
NCBI Gene

70060

			Length	Strain/Species	Flank
genomic	70060	NCBI Gene Model \| MGI Sequence Detail	11956	C57BL/6J	± kb
transcript	NM_027300	RefSeq \| MGI Sequence Detail	1107	C57BL/6
polypeptide	Q9D9T6	UniProt \| EBI \| MGI Sequence Detail	193	Not Applicable

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UniProt

8 Sequences
Protein Ontology

PR:000015490 spermatogenesis-associated protein 3

(term hierarchy)
InterPro Domains

IPR026717 Spermatogenesis-associated protein 3

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All nucleic 25

cDNA 25

Microarray probesets 4

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MGI:1916552, MGI:1921026

Summaries

All 34

Gene Ontology 4

Phenotypes 10
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Spata3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr7708	Chr1:85945790-85945806 (+)	70 bp
Tssr7709	Chr1:85949657-85949675 (+)	3,938 bp
Tssr7710	Chr1:85949681-85949694 (+)	3,960 bp
Tssr7711	Chr1:85949885-85949898 (+)	4,164 bp
Tssr7712	Chr1:85953925-85953935 (+)	8,202 bp
Tssr7713	Chr1:85954109-85954129 (+)	8,391 bp
Tssr7714	Chr1:85954148-85954170 (+)	8,431 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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