About   Help   FAQ
Prpf4 Gene Detail
Summary
  • Symbol
    Prpf4
  • Name
    pre-mRNA processing factor 4
  • Synonyms
    1600015H11Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1917302
    NCBI Gene: 70052
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:62327034-62345227 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 33.13 cM, cytoband C1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    443 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1917302
 protein coding gene Chr4:62327002-62345227 (+)
129S1/SvImJ ENSMUSG00200003388
 protein coding gene Chr4:57314199-57332392 (+)
A/J ENSMUSG00195007758
 protein coding gene Chr4:57901637-57919832 (+)
AKR/J ENSMUSG00220005206
 protein coding gene Chr4:57706011-57724205 (+)
BALB/cJ ENSMUSG00180028324
 protein coding gene Chr4:56854665-56872858 (+)
C3H/HeJ ENSMUSG00175020538
 protein coding gene Chr4:57651955-57670148 (+)
C57BL/6NJ ENSMUSG00215017385
 protein coding gene Chr4:57722080-57740273 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026078
 protein coding gene Chr4:56458979-56477569 (+)
CAST/EiJ ENSTCUG00005008195
 protein coding gene Chr4:57473772-57492392 (+)
CBA/J ENSMUSG00210004784
 protein coding gene Chr4:57388139-57406333 (+)
DBA/2J ENSMUSG00185018735
 protein coding gene Chr4:57775881-57794074 (+)
FVB/NJ ENSMUSG00205013605
 protein coding gene Chr4:56103654-56121849 (+)
JF1/MsJ ENSUMUG00000013921
 protein coding gene Chr4:58463263-58481538 (+)
LP/J ENSMUSG00230010734
 protein coding gene Chr4:61295223-61313416 (+)
NOD/ShiLtJ ENSMUSG00190027816
 protein coding gene Chr4:56808209-56826401 (+)
NZO/HlLtJ ENSMUSG00225012501
 protein coding gene Chr4:66323479-66341672 (+)
PWK/PhJ ENSLUMG00010007022
 protein coding gene Chr4:56082399-56100690 (+)
SPRET/EiJ ENSMSPG00010032946
 protein coding gene Chr4:57350702-57365465 (+)
WSB/EiJ ENSIUOG00005020936
 protein coding gene Chr4:57133349-57151578 (+)



Homology
more
  • Human Ortholog
    PRPF4, pre-mRNA splicing tri-snRNP complex factor PRPF4
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PRPF4, pre-mRNA splicing tri-snRNP complex factor PRPF4
  • Synonyms
    HPRP4, HPRP4P, PRP4, Prp4p, RP70, SNRNP60
  • Links
    NCBI Gene ID: 9128
    UniProt: O43172

  • Chr Location
    9q32; chr9:113275642-113294009 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human PRPF4 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    34
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    670
  • Tissues
    18
  • cDNA Data
    74
  • Literature Summary
    1
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000066148 Ensembl Gene Model | MGI Sequence Detail 18194 C57BL/6J ±  kb
transcript ENSMUST00000084524 Ensembl | MGI Sequence Detail 5223 Not Applicable  
polypeptide ENSMUSP00000081572 Ensembl | MGI Sequence Detail 521 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 76
    cDNA 75
    Primer pair 1
    Antibodies 1

    Microarray probesets 7
Other
Accession IDs
less
MGI:2140401, MGI:2140542
References
more
  • Summaries
    All 39
    Developmental Gene Expression 1
    Gene Ontology 6
    Phenotypes 7
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:381923 Giambruno R, et al., Affinity purification strategies for proteomic analysis of transcription factor complexes. J Proteome Res. 2013 Sep 6;12(9):4018-27
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory