Gpr15lg MGI Mouse Gene Detail - MGI:1917295 - G protein coupled receptor 15 ligand

Symbol

Gpr15lg
Name

G protein coupled receptor 15 ligand
Synonyms

2610528A11Rik

Feature Type

protein coding gene
IDs

MGI:1917295
NCBI Gene: 70045
Alliance

genome feature page
Transcription Start Sites

4 TSS

Sequence Map

Chr14:36824097-36832058 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 14, 21.29 cM
Mapping Data

2 experiments

SNPs within 2kb

362 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1917295	protein coding gene	Chr14:36824097-36835979 (-)
129S1/SvImJ	ENSMUSG00200037641	protein coding gene	Chr14:28722474-28730221 (-)
A/J	ENSMUSG00195013133	protein coding gene	Chr14:29727224-29735174 (-)
AKR/J	ENSMUSG00220029872	protein coding gene	Chr14:28877936-28885884 (-)
BALB/cJ	ENSMUSG00180026536	protein coding gene	Chr14:28815590-28823547 (-)
C3H/HeJ	ENSMUSG00175033971	protein coding gene	Chr14:28886986-28894938 (-)
C57BL/6NJ	ENSMUSG00215022921	protein coding gene	Chr14:29126786-29134736 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019134	protein coding gene	Chr14:29322211-29333813 (-)
CAST/EiJ	ENSTCUG00005020458	protein coding gene	Chr14:28940469-28948308 (-)
CBA/J	ENSMUSG00210043366	protein coding gene	Chr14:29133508-29141455 (-)
DBA/2J	ENSMUSG00185013584	protein coding gene	Chr14:33374152-33382103 (-)
FVB/NJ	ENSMUSG00205017517	protein coding gene	Chr14:28983735-28991686 (-)
JF1/MsJ	ENSUMUG00000033191	protein coding gene	Chr14:40709660-40717407 (-)
LP/J	ENSMUSG00230037170	protein coding gene	Chr14:40724924-40732647 (-)
NOD/ShiLtJ	ENSMUSG00190017912	protein coding gene	Chr14:29148889-29156803 (-)
NZO/HlLtJ	ENSMUSG00225041613	protein coding gene	Chr14:35028081-35035802 (-)
PWK/PhJ	ENSLUMG00010020445	protein coding gene	Chr14:17243071-17250990 (-)
SPRET/EiJ	ENSMSPG00010002680	protein coding gene	Chr14:30881535-30889398 (-)
WSB/EiJ	ENSIUOG00005011047	protein coding gene	Chr14:28942808-28950771 (-)

Human Ortholog

GPR15LG, G protein-coupled receptor 15 ligand

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

GPR15LG, G protein-coupled receptor 15 ligand
Synonyms

AP-57, AP57, C10orf99, CSBF, GPR15L, UNQ1833
Links

HGNC:31428

NCBI Gene ID: 387695

UniProt: Q6UWK7
Chr Location

10q23.1; chr10:84173801-84185294 (+) GRCh38

MGI Vertebrate Homology

Gpr15lg stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: GPR15LG
Gene Tree

Gpr15lg

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Phenotype Summary

4 phenotypes from 2 alleles in 2 genetic backgrounds
6 phenotypes from multigenic genotypes
9 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

5
Endonuclease-mediated

4
Targeted

1
Find Mice (IMSR)

7 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for one allele exhibit an increased mean serum IgG2a response to ovalbumin challenge. Mice homozygous for a second allele display altered large intestinal T cell homing and decreased susceptibility to induced colitis.

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All GO Annotations

43
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

598
Tissues

1
cDNA Data

48
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

GEO

Expression Atlas

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All Sequences

32
RefSeq

2
UniProt

1
CCDS

CCDS56949.1

Ensembl

ENSMUSG00000096001 (Evidence)
NCBI Gene

70045

			Length	Strain/Species	Flank
genomic	70045	NCBI Gene Model \| MGI Sequence Detail	7962	C57BL/6J	± kb
transcript	NM_001206684	RefSeq \| MGI Sequence Detail	756	C57BL/6
polypeptide	A0A0B4J1N3	UniProt \| EBI \| MGI Sequence Detail	78	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000059872 protein GPR15LG

(term hierarchy)
InterPro Domains

IPR031713 G-protein coupled receptor ligand 15

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All nucleic 48

cDNA 48

Microarray probesets 3

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MGI:2145819, MGI:7384681

Summaries

All 34

Developmental Gene Expression 1

Gene Ontology 8

Phenotypes 9
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:392233 Ocon B, et al., GPR15-GPR15L axis controls colon unconventional TCRalphabeta cells residency and enteroendocrine cell homeostasis to calibrate metabolism. Mucosal Immunol. 2026 Jun 25;:100370

TSS for Gpr15lg:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr128126	Chr14:36832044-36832063 (-)	4 bp
Tssr128125	Chr14:36832022-36832034 (-)	30 bp
Tssr128124	Chr14:36831982-36832018 (-)	58 bp
Tssr128123	Chr14:36824195-36824207 (-)	7,857 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/15/2026 MGI 6.29