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Dop1b Gene Detail
Summary
  • Symbol
    Dop1b
  • Name
    DOP1 leucine zipper like protein B
  • Synonyms
    0610038M01Rik, 2610510B01Rik, Dopey2, mKIAA0933
  • Feature Type
    protein coding gene
  • IDs
    MGI:1917278
    NCBI Gene: 70028
  • Alliance
    gene page
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:93508795-93607476 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 54.63 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    477 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1917278
 protein coding gene Chr16:93508792-93607478 (+)
129S1/SvImJ MGP_129S1SvImJ_G0023063
 protein coding gene Chr16:94905344-95010522 (+)
A/J MGP_AJ_G0023031
 protein coding gene Chr16:90454576-90555722 (+)
AKR/J MGP_AKRJ_G0023001
 protein coding gene Chr16:93225676-93334218 (+)
BALB/cJ MGP_BALBcJ_G0023033
 protein coding gene Chr16:90977077-91077950 (+)
C3H/HeJ MGP_C3HHeJ_G0022794
 protein coding gene Chr16:93729688-93837213 (+)
C57BL/6NJ MGP_C57BL6NJ_G0023480
 protein coding gene Chr16:97923369-98026113 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020982
 protein coding gene Chr16:88110374-88393496 (+)
CAST/EiJ MGP_CASTEiJ_G0022313
 protein coding gene Chr16:94448602-94560766 (+)
CBA/J MGP_CBAJ_G0022763
 protein coding gene Chr16:102160756-102275862 (+)
DBA/2J MGP_DBA2J_G0022897
 protein coding gene Chr16:90344316-90442912 (+)
FVB/NJ MGP_FVBNJ_G0022871
 protein coding gene Chr16:89499030-89599852 (+)
LP/J MGP_LPJ_G0022967
 protein coding gene Chr16:94576443-94681307 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0022892
 protein coding gene Chr16:106554393-106659677 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0023498
 protein coding gene Chr16:93730148-93836163 (+)
PWK/PhJ MGP_PWKPhJ_G0022058
 protein coding gene Chr16:90581050-90682373 (+)
SPRET/EiJ MGP_SPRETEiJ_G0021888
 protein coding gene Chr16:93273169-93376780 (+)
WSB/EiJ MGP_WSBEiJ_G0022364
 protein coding gene Chr16:93974548-94078821 (+)



Homology
more
  • Human Ortholog
    DOP1B, DOP1 leucine zipper like protein B
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DOP1B, DOP1 leucine zipper like protein B
  • Synonyms
    21orf5, C21orf5, DOPEY2
  • Links
    NCBI Gene ID: 9980
    neXtProt AC: NX_Q9Y3R5
    UniProt: Q9Y3R5

  • Chr Location
    21q22.12; chr21:36156781-36294274 (+)  GRCh38.p7
Human Diseases
less
  • References
    6 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 1 allele in 1 genetic background
    89 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    9
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    778
  • Tissues
    71
  • cDNA Data
    80
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 70028 NCBI Gene Model | MGI Sequence Detail 98682 C57BL/6J ±  kb
    transcript NM_001357118 RefSeq | MGI Sequence Detail 7338 C57BL/6  
    polypeptide Q3UHQ6 UniProt | EBI | MGI Sequence Detail 2295 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 83
      cDNA 80
      Primer pair 2
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1915620, MGI:2146448
    References
    more
    • Summaries
      All 124
      Developmental Gene Expression 4
      Diseases 6
      Gene Ontology 4
      Phenotypes 89
    • Earliest
      J:42265 Huang TT, et al., Superoxide-mediated cytotoxicity in superoxide dismutase-deficient fetal fibroblasts. Arch Biochem Biophys. 1997 Aug 15;344(2):424-32
    • Latest
      J:325522 Urbano-Gamez JD, et al., Prenatal treatment with rapamycin restores enhanced hippocampal mGluR-LTD and mushroom spine size in a Down's syndrome mouse model. Mol Brain. 2021 May 25;14(1):84
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    05/30/2023
    MGI 6.22     		The Jackson Laboratory