Dop1b MGI Mouse Gene Detail - MGI:1917278 - DOP1 leucine zipper like protein B

Symbol

Dop1b
Name

DOP1 leucine zipper like protein B
Synonyms

0610038M01Rik, 2610510B01Rik, Dopey2, mKIAA0933

Feature Type

protein coding gene
IDs

MGI:1917278
NCBI Gene: 70028
Alliance

gene page
Transcription Start Sites

12 TSS

Sequence Map

Chr16:93508795-93607476 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 16, 54.63 cM
Mapping Data

3 experiments

SNPs within 2kb

6631 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1917278	protein coding gene	Chr16:93508792-93607478 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0023063	protein coding gene	Chr16:94905344-95010522 (+)
A/J	MGP_AJ_G0023031	protein coding gene	Chr16:90454576-90555722 (+)
AKR/J	MGP_AKRJ_G0023001	protein coding gene	Chr16:93225676-93334218 (+)
BALB/cJ	MGP_BALBcJ_G0023033	protein coding gene	Chr16:90977077-91077950 (+)
C3H/HeJ	MGP_C3HHeJ_G0022794	protein coding gene	Chr16:93729688-93837213 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0023480	protein coding gene	Chr16:97923369-98026113 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020982	protein coding gene	Chr16:88110374-88393496 (+)
CAST/EiJ	MGP_CASTEiJ_G0022313	protein coding gene	Chr16:94448602-94560766 (+)
CBA/J	MGP_CBAJ_G0022763	protein coding gene	Chr16:102160756-102275862 (+)
DBA/2J	MGP_DBA2J_G0022897	protein coding gene	Chr16:90344316-90442912 (+)
FVB/NJ	MGP_FVBNJ_G0022871	protein coding gene	Chr16:89499030-89599852 (+)
LP/J	MGP_LPJ_G0022967	protein coding gene	Chr16:94576443-94681307 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0022892	protein coding gene	Chr16:106554393-106659677 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0023498	protein coding gene	Chr16:93730148-93836163 (+)
PWK/PhJ	MGP_PWKPhJ_G0022058	protein coding gene	Chr16:90581050-90682373 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0021888	protein coding gene	Chr16:93273169-93376780 (+)
WSB/EiJ	MGP_WSBEiJ_G0022364	protein coding gene	Chr16:93974548-94078821 (+)

Human Ortholog

DOP1B, DOP1 leucine zipper like protein B

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

DOP1B, DOP1 leucine zipper like protein B
Synonyms

21orf5, C21orf5, DOPEY2
Links

HGNC:1291

NCBI Gene ID: 9980

UniProt: Q9Y3R5
Chr Location

21q22.12; chr21:36156782-36294274 (+) GRCh38

MGI Vertebrate Homology

Dop1b stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: DOP1B
Gene Tree

Dop1b

less

References

6 with disease annotations

less

Phenotype Summary

9 phenotypes from 1 allele in 1 genetic background
100 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

37
Endonuclease-mediated

2
Gene trapped

22
Spontaneous

1
Targeted

10
Transgenic

1
Genomic Mutations

11 involving Dop1b
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

113 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

less

All GO Annotations

5
GO References

2

Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

779
Tissues

72
cDNA Data

80
Literature Summary

5

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase dop1b

less

All Sequences

109
RefSeq

46
UniProt

9
CCDS

CCDS28343.1, CCDS88972.1

Ensembl

ENSMUSG00000022946 (Evidence)
NCBI Gene

70028

			Length	Strain/Species	Flank
genomic	70028	NCBI Gene Model \| MGI Sequence Detail	98682	C57BL/6J	± kb
transcript	NM_001357118	RefSeq \| MGI Sequence Detail	7338	C57BL/6
polypeptide	Q3UHQ6	UniProt \| EBI \| MGI Sequence Detail	2295	Not Applicable

less

UniProt

9 Sequences
Protein Ontology

PR:000006640 protein DOP1B

(term hierarchy)
InterPro Domains

IPR007249 Dopey, N-terminal

IPR040314 Protein dopey
GlyGen

Q3UHQ6 2 sites, 1 O-linked glycan (1 site)

less

All nucleic 83

cDNA 80

Primer pair 2

Other 1

Microarray probesets 4

less

MGI:1915620, MGI:2146448, MGI:6192111

Summaries

All 135

Developmental Gene Expression 5

Diseases 6

Gene Ontology 2

Phenotypes 100
Earliest

J:42265 Huang TT, et al., Superoxide-mediated cytotoxicity in superoxide dismutase-deficient fetal fibroblasts. Arch Biochem Biophys. 1997 Aug 15;344(2):424-32
Latest

J:361105 Tateossian H, et al., DYRK1A kinase triplication is the major cause of Otitis Media in Down Syndrome. Elife. 2025;

TSS for Dop1b:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr139515	Chr16:93508800-93508809 (+)	10 bp
Tssr139516	Chr16:93508812-93508825 (+)	24 bp
Tssr139517	Chr16:93508840-93508896 (+)	73 bp
Tssr4966	Chr16:93527002-93527033 (+)	18,223 bp
Tssr139518	Chr16:93573597-93573611 (+)	64,809 bp
Tssr139519	Chr16:93574096-93574107 (+)	65,307 bp
Tssr139520	Chr16:93574129-93574153 (+)	65,346 bp
Tssr139521	Chr16:93575610-93575624 (+)	66,822 bp
Tssr139522	Chr16:93577833-93577868 (+)	69,056 bp
Tssr139523	Chr16:93585578-93585599 (+)	76,794 bp
Tssr139524	Chr16:93595743-93595792 (+)	86,973 bp
Tssr139525	Chr16:93606315-93606331 (+)	97,528 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 03/25/2025 MGI 6.24