Dop1b MGI Mouse Gene Detail - MGI:1917278 - DOP1 leucine zipper like protein B

Symbol

Dop1b
Name

DOP1 leucine zipper like protein B
Synonyms

0610038M01Rik, 2610510B01Rik, Dopey2, mKIAA0933

Feature Type

protein coding gene
IDs

MGI:1917278
NCBI Gene: 70028
Alliance

genome feature page
Transcription Start Sites

12 TSS

Sequence Map

Chr16:93508795-93607476 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 16, 54.63 cM
Mapping Data

3 experiments

SNPs within 2kb

3219 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1917278	protein coding gene	Chr16:93508792-93607478 (+)
129S1/SvImJ	ENSMUSG00200037027	protein coding gene	Chr16:90447139-90541675 (+)
A/J	ENSMUSG00195028063	protein coding gene	Chr16:90204862-90299386 (+)
AKR/J	ENSMUSG00220015622	protein coding gene	Chr16:90450164-90544707 (+)
BALB/cJ	ENSMUSG00180013885	protein coding gene	Chr16:90278845-90373373 (+)
C3H/HeJ	ENSMUSG00175015037	protein coding gene	Chr16:90615988-90710518 (+)
C57BL/6NJ	ENSMUSG00215016049	protein coding gene	Chr16:90403334-90497826 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020982	protein coding gene	Chr16:88110374-88393496 (+)
CAST/EiJ	ENSTCUG00005018120	protein coding gene	Chr16:89999643-90099330 (+)
CBA/J	ENSMUSG00210033434	protein coding gene	Chr16:90523526-90618049 (+)
DBA/2J	ENSMUSG00185032835	protein coding gene	Chr16:90462938-90557473 (+)
FVB/NJ	ENSMUSG00205020572	protein coding gene	Chr16:90242434-90336970 (+)
JF1/MsJ	ENSUMUG00000015451	protein coding gene	Chr16:90607132-90704035 (+)
LP/J	ENSMUSG00230024600	protein coding gene	Chr16:92993778-93088295 (+)
NOD/ShiLtJ	ENSMUSG00190024495	protein coding gene	Chr16:90431431-90525971 (+)
NZO/HlLtJ	ENSMUSG00225030090	protein coding gene	Chr16:96109280-96203807 (+)
PWK/PhJ	ENSLUMG00010013354	protein coding gene	Chr16:90246520-90342431 (+)
SPRET/EiJ	ENSMSPG00010019864	protein coding gene	Chr16:91382038-91453518 (+)
WSB/EiJ	ENSIUOG00005017958	protein coding gene	Chr16:90352824-90447257 (+)

Human Ortholog

DOP1B, DOP1 leucine zipper like protein B

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

DOP1B, DOP1 leucine zipper like protein B
Synonyms

21orf5, C21orf5, DOPEY2
Links

HGNC:1291

NCBI Gene ID: 9980

UniProt: Q9Y3R5
Chr Location

21q22.12; chr21:36156758-36294275 (+) GRCh38

MGI Vertebrate Homology

Dop1b stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: DOP1B
Gene Tree

Dop1b

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References

6 with disease annotations

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Phenotype Summary

9 phenotypes from 1 allele in 1 genetic background
102 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

37
Endonuclease-mediated

2
Gene trapped

22
Spontaneous

1
Targeted

10
Transgenic

1
Genomic Mutations

11 involving Dop1b
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

113 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

17
GO References

7

Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

670
Tissues

72
cDNA Data

80
Literature Summary

5

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase dop1b

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All Sequences

110
RefSeq

46
UniProt

9
CCDS

CCDS28343.1, CCDS88972.1

Ensembl

ENSMUSG00000022946 (Evidence)
NCBI Gene

70028

			Length	Strain/Species	Flank
genomic	70028	NCBI Gene Model \| MGI Sequence Detail	98682	C57BL/6J	± kb
transcript	NM_001357118	RefSeq \| MGI Sequence Detail	7338	C57BL/6
polypeptide	Q3UHQ6	UniProt \| EBI \| MGI Sequence Detail	2295	Not Applicable

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UniProt

9 Sequences
Protein Ontology

PR:000006640 protein DOP1B

(term hierarchy)
InterPro Domains

IPR056457 DOP1-like, C-terminal

IPR056458 DOP1-like, middle TPR domain

IPR056459 DOP1-like, TPR domain

IPR007249 DOP1, N-terminal

IPR040314 Protein DOP1
GlyGen

Q3UHQ6 2 sites, 1 O-linked glycan (1 site)

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All nucleic 83

cDNA 80

Primer pair 2

Other 1

Microarray probesets 4

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MGI:1915620, MGI:2146448, MGI:6192111

Summaries

All 143

Developmental Gene Expression 5

Diseases 6

Gene Ontology 7

Phenotypes 102
Earliest

J:42265 Huang TT, et al., Superoxide-mediated cytotoxicity in superoxide dismutase-deficient fetal fibroblasts. Arch Biochem Biophys. 1997 Aug 15;344(2):424-32
Latest

J:385727 Harada K, et al., Preventing Differentiation Towards Primitive Macrophages in Stem Cells With Down Syndrome. Immunology. 2026 Mar;177(3):596-612

TSS for Dop1b:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr139515	Chr16:93508800-93508809 (+)	10 bp
Tssr139516	Chr16:93508812-93508825 (+)	24 bp
Tssr139517	Chr16:93508840-93508896 (+)	73 bp
Tssr4966	Chr16:93527002-93527033 (+)	18,223 bp
Tssr139518	Chr16:93573597-93573611 (+)	64,809 bp
Tssr139519	Chr16:93574096-93574107 (+)	65,307 bp
Tssr139520	Chr16:93574129-93574153 (+)	65,346 bp
Tssr139521	Chr16:93575610-93575624 (+)	66,822 bp
Tssr139522	Chr16:93577833-93577868 (+)	69,056 bp
Tssr139523	Chr16:93585578-93585599 (+)	76,794 bp
Tssr139524	Chr16:93595743-93595792 (+)	86,973 bp
Tssr139525	Chr16:93606315-93606331 (+)	97,528 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/08/2026 MGI 6.24