Nt5dc2 MGI Mouse Gene Detail - MGI:1917271 - 5'-nucleotidase domain containing 2

Symbol

Nt5dc2
Name

5'-nucleotidase domain containing 2
Synonyms

2510015F01Rik

Feature Type

protein coding gene
IDs

MGI:1917271
NCBI Gene: 70021
Alliance

gene page
Transcription Start Sites

10 TSS

Sequence Map

Chr14:30853046-30861081 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 14, 19.09 cM
Mapping Data

1 experiment

SNPs within 2kb

237 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1917271	protein coding gene	Chr14:30853010-30861081 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0021119	protein coding gene	Chr14:24301972-24311459 (+)
A/J	MGP_AJ_G0021067	protein coding gene	Chr14:23385161-23392874 (+)
AKR/J	MGP_AKRJ_G0021044	protein coding gene	Chr14:24509074-24516842 (+)
BALB/cJ	MGP_BALBcJ_G0021071	protein coding gene	Chr14:23506615-23514511 (+)
C3H/HeJ	MGP_C3HHeJ_G0020854	protein coding gene	Chr14:24378347-24382444 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0021503	protein coding gene	Chr14:25274434-25281579 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019066	protein coding gene	Chr14:23448081-23455992 (+)
CAST/EiJ	MGP_CASTEiJ_G0020379	protein coding gene	Chr14:24141093-24149624 (+)
CBA/J	MGP_CBAJ_G0020821	protein coding gene	Chr14:26247633-26253905 (+)
DBA/2J	MGP_DBA2J_G0020943	protein coding gene	Chr14:23414724-23422554 (+)
FVB/NJ	MGP_FVBNJ_G0020927	protein coding gene	Chr14:23380618-23384971 (+)
LP/J	MGP_LPJ_G0021012	protein coding gene	Chr14:24629008-24638668 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0020953	protein coding gene	Chr14:25513138-25518726 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0021536	protein coding gene	Chr14:24273288-24277506 (+)
PWK/PhJ	MGP_PWKPhJ_G0020127	protein coding gene	Chr14:22870430-22878132 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0019951	protein coding gene	Chr14:23866132-23873887 (+)
WSB/EiJ	MGP_WSBEiJ_G0020434	protein coding gene	Chr14:24328377-24336172 (+)

Human Ortholog

NT5DC2, 5'-nucleotidase domain containing 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

NT5DC2, 5'-nucleotidase domain containing 2
Links

HGNC:25717

NCBI Gene ID: 64943

UniProt: Q9H857
Chr Location

3p21.1; chr3:52524385-52535054 (-) GRCh38

MGI Vertebrate Homology

Nt5dc2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: NT5DC2
Protein SuperFamily

Purine_5'-nucleotidase
Gene Tree

Nt5dc2

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Phenotype Summary

8 phenotypes from 1 allele in 1 genetic background
8 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Endonuclease-mediated

1
Gene trapped

3
Targeted

2
Incidental Mutations

CvDC
Find Mice (IMSR)

17 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

1
GO References

1

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

No experimental evidence to support Cellular Component annotation, following literature review. See J:73796.

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

854
Tissues

27
cDNA Data

98
Literature Summary

5

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase LOC100124988

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All Sequences

45
RefSeq

4
UniProt

6
CCDS

CCDS36852.1, CCDS88613.1

Ensembl

ENSMUSG00000071547 (Evidence)
NCBI Gene

70021

			Length	Strain/Species	Flank
genomic	70021	NCBI Gene Model \| MGI Sequence Detail	8036	C57BL/6J	± kb
transcript	NM_001374087	RefSeq \| MGI Sequence Detail	1812	C57BL/6
polypeptide	NP_001361016	RefSeq \| MGI Sequence Detail	553	C57BL/6

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UniProt

6 Sequences
InterPro Domains

IPR036412 HAD-like superfamily

IPR023214 HAD superfamily

IPR008380 HAD-superfamily hydrolase, subfamily IG, 5'-nucleotidase

IPR016695 Purine 5'-nucleotidase
GlyGen

A0A2I3BR81 1 site, 1 O-linked glycan (1 site)

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All nucleic 101

cDNA 98

Primer pair 3

Microarray probesets 3

Summaries

All 31

Developmental Gene Expression 5

Gene Ontology 1

Phenotypes 8
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Nt5dc2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr124915	Chr14:30853010-30853019 (+)	-31 bp
Tssr124916	Chr14:30853036-30853068 (+)	6 bp
Tssr124917	Chr14:30853072-30853077 (+)	29 bp
Tssr124918	Chr14:30856687-30856722 (+)	3,659 bp
Tssr124919	Chr14:30857659-30857679 (+)	4,623 bp
Tssr124920	Chr14:30860018-30860043 (+)	6,985 bp
Tssr124921	Chr14:30860282-30860305 (+)	7,248 bp
Tssr124922	Chr14:30860315-30860332 (+)	7,278 bp
Tssr124923	Chr14:30860768-30860804 (+)	7,740 bp
Tssr124924	Chr14:30860972-30860981 (+)	7,931 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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