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Ino80b Gene Detail
Summary
  • Symbol
    Ino80b
  • Name
    INO80 complex subunit B
  • Synonyms
    2510009I23Rik, HMG1YL4, Hmga1l4, Papa1, Znhit4
  • Feature Type
    protein coding gene
  • IDs
    MGI:1917270
    NCBI Gene: 70020
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:83098746-83102100 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 35.94 cM, cytoband D1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    149 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1917270
 protein coding gene Chr6:83098746-83102412 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030922
 protein coding gene Chr6:84129206-84132865 (-)
A/J MGP_AJ_G0030891
 protein coding gene Chr6:80912932-80916603 (-)
AKR/J MGP_AKRJ_G0030819
 protein coding gene Chr6:83243353-83247024 (-)
BALB/cJ MGP_BALBcJ_G0030901
 protein coding gene Chr6:80925815-80929486 (-)
C3H/HeJ MGP_C3HHeJ_G0030809
 protein coding gene Chr6:101135219-101138885 (+)
C57BL/6NJ MGP_C57BL6NJ_G0031361
 protein coding gene Chr6:86412420-86416086 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028547
 protein coding gene Chr6:79271962-79275782 (-)
CAST/EiJ MGP_CASTEiJ_G0030010
 protein coding gene Chr6:83250656-83254343 (-)
CBA/J MGP_CBAJ_G0030588
 protein coding gene Chr6:89823739-89827405 (-)
DBA/2J MGP_DBA2J_G0030741
 protein coding gene Chr6:80233196-80236862 (-)
FVB/NJ MGP_FVBNJ_G0030694
 protein coding gene Chr6:79440087-79443760 (-)
LP/J MGP_LPJ_G0030820
 protein coding gene Chr6:84121276-84124935 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030730
 protein coding gene Chr6:94141643-94145314 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031385
 protein coding gene Chr6:83058091-83062582 (-)
PWK/PhJ MGP_PWKPhJ_G0029725
 protein coding gene Chr6:79126064-79129746 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029553
 protein coding gene Chr6:81904820-81908426 (-)
WSB/EiJ MGP_WSBEiJ_G0030091
 protein coding gene Chr6:83495608-83499279 (-)



Homology
more
  • Human Ortholog
    INO80B, INO80 complex subunit B
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    INO80B, INO80 complex subunit B
  • Synonyms
    hIes2, HMGA1L4, HMGIYL4, IES2, PAP-1BP, PAPA-1, PAPA1, ZNHIT4
  • Links
    NCBI Gene ID: 83444
    neXtProt AC: NX_Q9C086
    UniProt: Q9C086

  • Chr Location
    2p13.1; chr2:74455087-74457944 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    34
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    713
  • Tissues
    5
  • cDNA Data
    46
  • Literature Summary
    2
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 70020 NCBI Gene Model | MGI Sequence Detail 3355 C57BL/6J ±  kb
transcript NM_023547 RefSeq | MGI Sequence Detail 1191 C57BL/6  
polypeptide Q99PT3 UniProt | EBI | MGI Sequence Detail 375 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 46
    cDNA 46

    Microarray probesets 5
References
more
  • Summaries
    All 41
    Developmental Gene Expression 2
    Gene Ontology 8
    Phenotypes 12
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:337681 Yang G, et al., Germ cell-specific eIF4E1b regulates maternal mRNA translation to ensure zygotic genome activation. Genes Dev. 2023 May 1;37(9-10):418-431
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory