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Hnrnpa3 Gene Detail
Summary
  • Symbol
    Hnrnpa3
  • Name
    heterogeneous nuclear ribonucleoprotein A3
  • Synonyms
    2410013L13Rik, 2610209F03Rik, 2610510D13Rik, Hnrpa3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1917171
    NCBI Gene: 229279
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:75489605-75499751 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 44.75 cM, cytoband A7.2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    45 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1917171
protein coding gene Chr2:75489416-75499751 (+)
129S1/SvImJ MGP_129S1SvImJ_G0025856
protein coding gene Chr2:76022873-76030431 (+)
A/J MGP_AJ_G0025834
protein coding gene Chr2:73046756-73056592 (+)
AKR/J MGP_AKRJ_G0025802
protein coding gene Chr2:75019724-75029787 (+)
BALB/cJ MGP_BALBcJ_G0025828
protein coding gene Chr2:73235238-73245516 (+)
C3H/HeJ MGP_C3HHeJ_G0025588
protein coding gene Chr2:75221757-75228664 (+)
C57BL/6NJ MGP_C57BL6NJ_G0026275
protein coding gene Chr2:78281440-78293703 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0023678
protein coding gene Chr2:70462970-70472928 (+)
CAST/EiJ MGP_CASTEiJ_G0025052
protein coding gene Chr2:75541941-75556068 (+)
CBA/J MGP_CBAJ_G0025569
protein coding gene Chr2:81144984-81154759 (+)
DBA/2J MGP_DBA2J_G0025700
protein coding gene Chr2:72643240-72653735 (+)
FVB/NJ MGP_FVBNJ_G0025662
protein coding gene Chr2:72032028-72041800 (+)
LP/J MGP_LPJ_G0025788
protein coding gene Chr2:75871208-75885385 (+)
NOD/ShiLtJ no annotation
NZO/HlLtJ MGP_NZOHlLtJ_G0026332
protein coding gene Chr2:75140101-75151723 (+)
PWK/PhJ MGP_PWKPhJ_G0024793
protein coding gene Chr2:72601224-72610915 (+)
SPRET/EiJ MGP_SPRETEiJ_G0024601
protein coding gene Chr2:75381674-75384851 (+)
WSB/EiJ MGP_WSBEiJ_G0025120
protein coding gene Chr2:75599425-75611135 (+)



Homology
more
  • Human Ortholog
    HNRNPA3, heterogeneous nuclear ribonucleoprotein A3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HNRNPA3, heterogeneous nuclear ribonucleoprotein A3
  • Synonyms
    2610510D13Rik, D10S102, FBRNP, HNRPA3
  • Links
    NCBI Gene ID: 220988
    neXtProt AC: NX_P51991
    UniProt: P51991

  • Chr Location
    2q31.2; chr2:177212694-177223959 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    16 phenotypes from 1 allele in 1 genetic background
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit neonatal lethality, lung developmental defects, reduced cortex thickness, and a mitotic delay in apical cortical progenitors resulting in impaired neurogenesis of early born deep-layer neurons.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000059005 Ensembl Gene Model | MGI Sequence Detail 10147 C57BL/6J ±  kb
    transcript ENSMUST00000090792 Ensembl | MGI Sequence Detail 1140 Not Applicable  
    polypeptide ENSMUSP00000088298 Ensembl | MGI Sequence Detail 379 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      10 Sequences
    • Protein Ontology
      PR:000008866 heterogeneous nuclear ribonucleoprotein A3
    • InterPro Domains
      IPR021662 Heterogeneous nuclear ribonucleoprotein A1/A2, C-terminal
      IPR034516 hnRNP A1/3, RNA recognition motif 2
      IPR034513 hnRNP A3, RNA recognition motif 1
      IPR012677 Nucleotide-binding alpha-beta plait domain superfamily
      IPR035979 RNA-binding domain superfamily
      IPR000504 RNA recognition motif domain
    Molecular
    Reagents
    less
    • All nucleic 24
      cDNA 21
      Primer pair 2
      Other 1

      Microarray probesets 14
    Other
    Accession IDs
    less
    MGI:2149671, MGI:2149675
    References
    more
    • Summaries
      All 43
      Developmental Gene Expression 4
      Gene Ontology 4
      Phenotypes 15
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:288307 Ou MY, et al., Heterogeneous nuclear ribonucleoprotein A3 controls mitotic progression of neural progenitors via interaction with cohesin. Development. 2020 May 15;147(10):dev185132

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    01/31/2023
    MGI 6.22
    The Jackson Laboratory