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Rab43 Gene Detail
Summary
  • Symbol
    Rab43
  • Name
    RAB43, member RAS oncogene family
  • Synonyms
    1810048P08Rik, 2500004H21Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1917084
    NCBI Gene: 69834
  • Alliance
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:87765835-87789146 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 6, 39.13 cM, cytoband D2
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    57 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1917084
protein coding gene Chr6:87765835-87789146 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030998
protein coding gene Chr6:89153695-89180131 (-)
A/J MGP_AJ_G0030964
protein coding gene Chr6:85713200-85736592 (-)
AKR/J MGP_AKRJ_G0030895
protein coding gene Chr6:88192064-88215245 (-)
BALB/cJ MGP_BALBcJ_G0030977
protein coding gene Chr6:85708419-85731543 (-)
C3H/HeJ MGP_C3HHeJ_G0030733
protein coding gene Chr6:96256583-96279862 (+)
C57BL/6NJ MGP_C57BL6NJ_G0031434
protein coding gene Chr6:91544976-91568252 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028617
protein coding gene Chr6:83885926-83909051 (-)
CAST/EiJ MGP_CASTEiJ_G0030086
protein coding gene Chr6:88272554-88295728 (-)
CBA/J MGP_CBAJ_G0030661
protein coding gene Chr6:95089369-95112603 (-)
DBA/2J MGP_DBA2J_G0030817
protein coding gene Chr6:85013179-85036487 (-)
FVB/NJ MGP_FVBNJ_G0030770
protein coding gene Chr6:84199847-84224005 (-)
LP/J MGP_LPJ_G0030894
protein coding gene Chr6:89170929-89198765 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030803
protein coding gene Chr6:99225707-99248832 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031461
protein coding gene Chr6:88045174-88068420 (-)
PWK/PhJ MGP_PWKPhJ_G0029801
protein coding gene Chr6:83981089-84004821 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029629
protein coding gene Chr6:86861073-86884204 (-)
WSB/EiJ MGP_WSBEiJ_G0030167
protein coding gene Chr6:88495108-88520104 (-)



Homology
more
  • Human Ortholog
    RAB43, RAB43, member RAS oncogene family
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RAB43, RAB43, member RAS oncogene family
  • Synonyms
    RAB11B, RAB41
  • Links
    NCBI Gene ID: 339122
    neXtProt AC: NX_Q86YS6
    UniProt: Q86YS6

  • Chr Location
    3q21.3; chr3:129087569-129122801 (-)  GRCh38

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 2 alleles in 2 genetic backgrounds
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit defects in dendritic cell antigen presentation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 69834 NCBI Gene Model | MGI Sequence Detail 23312 C57BL/6J ±  kb
    transcript NM_001039394 RefSeq | MGI Sequence Detail 4605 C57BL/6  
    polypeptide Q8CG50 UniProt | EBI | MGI Sequence Detail 210 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 67
      cDNA 67

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1917339, MGI:2141679
    References
    more
    • Summaries
      All 42
      Developmental Gene Expression 1
      Gene Ontology 5
      Phenotypes 14
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:336195 Wang Y, et al., Extracellular HMGB1 Impairs Macrophage-Mediated Efferocytosis by Suppressing the Rab43-Controlled Cell Surface Transport of CD91. Front Immunol. 2022;13:767630

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    03/19/2024
    MGI 6.23
    The Jackson Laboratory