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Pou2af2 Gene Detail
Summary
  • Symbol
    Pou2af2
  • Name
    POU domain, class 2, associating factor 2
  • Synonyms
    1810046K07Rik, OCA-B homolog, Oca-t1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1917059
    NCBI Gene: 69809
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:51200986-51240224 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 28.05 cM, cytoband B
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    265 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1917059
 protein coding gene Chr9:51200986-51240224 (-)
129S1/SvImJ MGP_129S1SvImJ_G0034800
 protein coding gene Chr9:50213109-50257989 (-)
A/J MGP_AJ_G0034781
 protein coding gene Chr9:48687064-48727449 (-)
AKR/J MGP_AKRJ_G0034709
 protein coding gene Chr9:49702850-49741951 (-)
BALB/cJ MGP_BALBcJ_G0034773
 protein coding gene Chr9:48437746-48476811 (-)
C3H/HeJ MGP_C3HHeJ_G0034483
 protein coding gene Chr9:50198162-50237259 (-)
C57BL/6NJ MGP_C57BL6NJ_G0035293
 protein coding gene Chr9:51621245-51663361 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032206
 protein coding gene Chr9:48148097-48187358 (-)
CAST/EiJ MGP_CASTEiJ_G0033805
 protein coding gene Chr9:50138273-50184538 (-)
CBA/J MGP_CBAJ_G0034455
 protein coding gene Chr9:53447934-53491509 (-)
DBA/2J MGP_DBA2J_G0034614
 protein coding gene Chr9:48543465-48582687 (-)
FVB/NJ MGP_FVBNJ_G0034555
 protein coding gene Chr9:47760426-47799542 (-)
LP/J MGP_LPJ_G0034695
 protein coding gene Chr9:50581062-50622703 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0034598
 protein coding gene Chr9:55017913-55058080 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0035314
 protein coding gene Chr9:49697742-49737046 (-)
PWK/PhJ MGP_PWKPhJ_G0033510
 protein coding gene Chr9:48526902-48566366 (-)
SPRET/EiJ MGP_SPRETEiJ_G0033345
 protein coding gene Chr9:49988270-50028022 (-)
WSB/EiJ MGP_WSBEiJ_G0033918
 protein coding gene Chr9:49699704-49739441 (-)



Homology
more
  • Human Ortholog
    POU2AF2, POU class 2 homeobox associating factor 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    POU2AF2, POU class 2 homeobox associating factor 2
  • Synonyms
    C11orf53, OCAT1, OCA-T1
  • Links
    NCBI Gene ID: 341032
    neXtProt AC: NX_Q8IXP5
    UniProt: Q8IXP5

  • Chr Location
    11q23.1; chr11:111245725-111286401 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 1 allele in 1 genetic background
    1 phenotype reference
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice show no detectable tuft cells in the trachea, small intestine, urethra, gall bladder, tongue and nasal epithelium and partial loss in the colon via marker analysis. Otherwise, mice show normal morphology and organ histology.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    12
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 69809 NCBI Gene Model | MGI Sequence Detail 39239 C57BL/6J ±  kb
    transcript NM_001372554 RefSeq | MGI Sequence Detail 1326 C57BL/6  
    polypeptide Q9D8Q6 UniProt | EBI | MGI Sequence Detail 287 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 6
      cDNA 6

      Microarray probesets 2
    References
    more
    • Summaries
      All 25
      Gene Ontology 6
      Phenotypes 1
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:325394 Wu XS, et al., OCA-T1 and OCA-T2 are coactivators of POU2F3 in the tuft cell lineage. Nature. 2022 May 16;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/09/2024
    MGI 6.23     		The Jackson Laboratory