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Pof1b Gene Detail
Summary
  • Symbol
    Pof1b
  • Name
    premature ovarian failure 1B
  • Synonyms
    2310066B14Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1916943
    NCBI Gene: 69693
  • Alliance
    genome feature page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:111548128-111608348 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 48.76 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    930 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1916943
 protein coding gene ChrX:111548124-111608408 (-)
129S1/SvImJ ENSMUSG00200024389
 protein coding gene ChrX:93365253-93425476 (-)
A/J ENSMUSG00195025793
 protein coding gene ChrX:97079951-97140982 (-)
AKR/J ENSMUSG00220013225
 protein coding gene ChrX:91325373-91385595 (-)
BALB/cJ ENSMUSG00180025603
 protein coding gene ChrX:93741517-93802551 (-)
C3H/HeJ ENSMUSG00175027844
 protein coding gene ChrX:97346935-97407992 (-)
C57BL/6NJ ENSMUSG00215014193
 protein coding gene ChrX:93986592-94046810 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0033358
 protein coding gene ChrX:105930485-105990733 (-)
CAST/EiJ ENSTCUG00005020751
 protein coding gene ChrX:94691040-94752341 (-)
CBA/J ENSMUSG00210022189
 protein coding gene ChrX:94213757-94274762 (-)
DBA/2J ENSMUSG00185028793
 protein coding gene ChrX:106693308-106753528 (-)
FVB/NJ ENSMUSG00205018013
 protein coding gene ChrX:93301604-93361831 (-)
JF1/MsJ ENSUMUG00000015640
 protein coding gene ChrX:127297054-127358060 (-)
LP/J ENSMUSG00230005313
 protein coding gene ChrX:113330619-113390838 (-)
NOD/ShiLtJ ENSMUSG00190012984
 protein coding gene ChrX:93436375-93496587 (-)
NZO/HlLtJ ENSMUSG00225040300
 protein coding gene ChrX:118483317-118543564 (-)
PWK/PhJ ENSLUMG00010025773
 protein coding gene ChrX:92575967-92636855 (-)
SPRET/EiJ ENSMSPG00010021176
 protein coding gene ChrX:96950972-97010533 (-)
WSB/EiJ ENSIUOG00005014901
 protein coding gene ChrX:93793348-93853590 (-)



Homology
more
  • Human Ortholog
    POF1B, POF1B actin binding protein
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    POF1B, POF1B actin binding protein
  • Synonyms
    POF, POF2B
  • Links
    NCBI Gene ID: 79983
    UniProt: Q8WVV4

  • Chr Location
    Xq21.1; chrX:85276746-85379755 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human POF1B associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 2 alleles in 2 genetic backgrounds
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Both male and female mice homozygous for a targeted knockout mutation of this gene are viable and fertile have no reported abnormal phenotype.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    28
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    688
  • Tissues
    49
  • cDNA Data
    10
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000034607 Ensembl Gene Model | MGI Sequence Detail 60221 C57BL/6J ±  kb
    transcript ENSMUST00000039887 Ensembl | MGI Sequence Detail 3886 Not Applicable  
    polypeptide ENSMUSP00000047655 Ensembl | MGI Sequence Detail 587 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 13
      cDNA 11
      Primer pair 2
      Antibodies 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 31
      Developmental Gene Expression 2
      Gene Ontology 5
      Phenotypes 7
    • Earliest
      J:87287 Bione S, et al., X chromosome genes and premature ovarian failure. Semin Reprod Med. 2000;18(1):51-7
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory