Ddx51 MGI Mouse Gene Detail - MGI:1916913

Symbol

Ddx51
Name

DEAD box helicase 51
Synonyms

2310061O04Rik, DEAD (Asp-Glu-Ala-Asp) box polypeptide 51

Feature Type

protein coding gene
IDs

MGI:1916913
NCBI Gene: 69663
Alliance

gene page
Transcription Start Sites

1 TSS

Sequence Map

Chr5:110801317-110808362 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 5, 53.69 cM
Mapping Data

2 experiments

SNPs within 2kb

64 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1916913	protein coding gene	Chr5:110801298-110810885 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0029890	protein coding gene	Chr5:113128134-113135180 (+)
A/J	MGP_AJ_G0029856	protein coding gene	Chr5:108743244-108750289 (+)
AKR/J	MGP_AKRJ_G0029794	protein coding gene	Chr5:112192301-112199346 (+)
BALB/cJ	MGP_BALBcJ_G0029867	protein coding gene	Chr5:110112370-110119415 (+)
C3H/HeJ	MGP_C3HHeJ_G0029587	protein coding gene	Chr5:112626554-112633599 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0030320	protein coding gene	Chr5:117576137-117583182 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0027549	protein coding gene	Chr5:103577497-103585193 (+)
CAST/EiJ	MGP_CASTEiJ_G0028995	protein coding gene	Chr5:111505354-111512438 (+)
CBA/J	MGP_CBAJ_G0029554	protein coding gene	Chr5:122002583-122009628 (+)
DBA/2J	MGP_DBA2J_G0029704	protein coding gene	Chr5:108819027-108826072 (+)
FVB/NJ	MGP_FVBNJ_G0029661	protein coding gene	Chr5:107486363-107493408 (+)
LP/J	MGP_LPJ_G0029792	protein coding gene	Chr5:113683875-113690921 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0029692	protein coding gene	Chr5:126646248-126653293 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0030361	protein coding gene	Chr5:111635103-111642149 (+)
PWK/PhJ	MGP_PWKPhJ_G0028709	protein coding gene	Chr5:107397814-107405571 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0028547	protein coding gene	Chr5:109107516-109114541 (+)
WSB/EiJ	MGP_WSBEiJ_G0029071	protein coding gene	Chr5:112111292-112118337 (+)

Human Ortholog

DDX51, DEAD-box helicase 51

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

DDX51, DEAD-box helicase 51
Links

HGNC:20082

NCBI Gene ID: 317781

neXtProt AC: NX_Q8N8A6

UniProt: Q8N8A6
Chr Location

12q24.33; chr12:132136594-132144319 (-) GRCh38

MGI Vertebrate Homology

Ddx51 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: DDX51
Gene Tree

Ddx51

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Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
9 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

3
Chemically induced (other)

1
Radiation induced

1
Targeted

1
Genomic Mutations

2 involving Ddx51
Incidental Mutations

APF
Find Mice (IMSR)

13 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

7
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

707
Tissues

1
cDNA Data

10
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ddx51

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All Sequences

50
RefSeq

3
UniProt

4
CCDS

CCDS19528.1

Ensembl

ENSMUSG00000029504 (Evidence)
NCBI Gene

69663

			Length	Strain/Species	Flank
genomic	ENSMUSG00000029504	Ensembl Gene Model \| MGI Sequence Detail	7046	C57BL/6J	± kb
transcript	ENSMUST00000031478	Ensembl \| MGI Sequence Detail	4846	Not Applicable
polypeptide	ENSMUSP00000031478	Ensembl \| MGI Sequence Detail	639	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000006368 ATP-dependent RNA helicase DDX51

(term hierarchy)
EC

3.6.4.13
InterPro Domains

IPR000629 ATP-dependent RNA helicase DEAD-box, conserved site

IPR011545 DEAD/DEAH box helicase domain

IPR001650 Helicase, C-terminal domain-like

IPR014001 Helicase superfamily 1/2, ATP-binding domain

IPR027417 P-loop containing nucleoside triphosphate hydrolase

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All nucleic 10

cDNA 10

Microarray probesets 3

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MGI:2140771, MGI:2141325, MGI:2141352

Summaries

All 36

Developmental Gene Expression 1

Gene Ontology 5

Phenotypes 9
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:274872 Ingham NJ, et al., Mouse screen reveals multiple new genes underlying mouse and human hearing loss. PLoS Biol. 2019 Apr;17(4):e3000194

TSS for Ddx51:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr47908	Chr5:110801310-110801348 (+)	12 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/09/2024 MGI 6.23